ID ADEC2_RHIME Reviewed; 593 AA.
AC Q92VC6;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Adenine deaminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE Short=Adenase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE Short=Adenine aminase 2 {ECO:0000255|HAMAP-Rule:MF_01518};
DE EC=3.5.4.2 {ECO:0000255|HAMAP-Rule:MF_01518};
GN Name=ade2 {ECO:0000255|HAMAP-Rule:MF_01518}; Synonyms=adeC2;
GN OrderedLocusNames=RB0782; ORFNames=SMb21278;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OG Plasmid pSymB (megaplasmid 2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481431; DOI=10.1073/pnas.161294698;
RA Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P., Vorhoelter F.J.,
RA Hernandez-Lucas I., Becker A., Cowie A., Gouzy J., Golding B., Puehler A.;
RT "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-fixing
RT endosymbiont Sinorhizobium meliloti.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01518};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenine deaminase family. {ECO:0000255|HAMAP-Rule:MF_01518}.
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DR EMBL; AL591985; CAC49182.1; -; Genomic_DNA.
DR PIR; F95939; F95939.
DR RefSeq; NP_437322.1; NC_003078.1.
DR RefSeq; WP_010975638.1; NC_003078.1.
DR AlphaFoldDB; Q92VC6; -.
DR SMR; Q92VC6; -.
DR EnsemblBacteria; CAC49182; CAC49182; SM_b21278.
DR GeneID; 61600758; -.
DR KEGG; sme:SM_b21278; -.
DR PATRIC; fig|266834.11.peg.5711; -.
DR eggNOG; COG1001; Bacteria.
DR HOGENOM; CLU_027935_0_0_5; -.
DR OrthoDB; 9775607at2; -.
DR Proteomes; UP000001976; Plasmid pSymB.
DR GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR CDD; cd01295; AdeC; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR HAMAP; MF_01518; Adenine_deamin; 1.
DR InterPro; IPR006679; Adenine_deam.
DR InterPro; IPR026912; Adenine_deam_C.
DR InterPro; IPR006680; Amidohydro-rel.
DR InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR Pfam; PF13382; Adenine_deam_C; 1.
DR Pfam; PF01979; Amidohydro_1; 1.
DR SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase; Manganese; Plasmid; Reference proteome.
FT CHAIN 1..593
FT /note="Adenine deaminase 2"
FT /id="PRO_0000142433"
SQ SEQUENCE 593 AA; 61858 MW; 6CF4C794779D4E7A CRC64;
MTVLQQPADL DDACLRARAV AAARGDARFD VLVAGGTVVD VVTGECRAAD VGIVGALIAS
VHAPGSRSDA DTVIDAAGAY ISPGLIDTHM HVESSMVTPA VYAAAVVPRG VTTVVWDPHE
FGNVSGLAGV RWAVDAMGGL PLRAVVLAPS CVPSAPGLEV AGADFDADAV AEMLSWPEIG
GIAEVMNMRG VIDGDPRMTA IVEAGLKAGK PVNGHARGLE GADLQAFVTA GVSSDHELVS
GDDLIAKLRA GLSIELRGSH DHLLPEFVIA LGTLGHLPQT VTLCTDDVFP DDLHRDGGLD
DVVRRLVRYG LKAEWALQAA TLNAARRLGR ADLGLIAPGR RADIVLFEDI RDFRALHVLA
NGRLVASGGG MLQAPVAAGV SPLRHTMKIE PLTEDDFRIA ATGSTARVVT IDRPRFTRWG
ETRAEVSGGY LVPPKGMTLI AVAHRHGRAD SRPRVGLLEG WGEWRGAFAT TVSHDSHNLT
VFGSSPRDMR VAANAVIEAG GGMAVVAEGK VEALLPLPLC GLVSDAPLAE VAAGFAAIRE
AAGRIVEWQP PYLVFKACFG ATLACNAGPH QTDRGIADVA TGKLLESPVL ETF
//
