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Database: UniProt
Entry: ADRM1_BOVIN
LinkDB: ADRM1_BOVIN
Original site: ADRM1_BOVIN 
ID   ADRM1_BOVIN             Reviewed;         407 AA.
AC   A1L5A6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   08-MAY-2019, entry version 76.
DE   RecName: Full=Proteasomal ubiquitin receptor ADRM1;
DE   AltName: Full=Rpn13 homolog;
GN   Name=ADRM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC       involved in the ATP-dependent degradation of ubiquitinated
CC       proteins. This complex plays a key role in the maintenance of
CC       protein homeostasis by removing misfolded or damaged proteins,
CC       which could impair cellular functions, and by removing proteins
CC       whose functions are no longer required. Therefore, the proteasome
CC       participates in numerous cellular processes, including cell cycle
CC       progression, apoptosis, or DNA damage repair. Within the complex,
CC       functions as a proteasomal ubiquitin receptor. Engages and thus
CC       activates 19S-associated deubiquitinases UCHL5 and PSMD14 during
CC       protein degradation. UCHL5 reversibly associate with the 19S
CC       regulatory particle whereas PSMD14 is an intrinsic subunit of the
CC       proteasome lid subcomplex. {ECO:0000250|UniProtKB:Q16186}.
CC   -!- SUBUNIT: Component of the 19S proteasome regulatory particle
CC       complex. The 26S proteasome consists of a 20S core particle (CP)
CC       and two 19S regulatory subunits (RP). Interacts with the
CC       proteasomal scaffolding protein PSMD1. Interacts with
CC       deubiquitinase UCHL5; this interaction activates the auto-
CC       inhibited UCHL5 by deoligomerizing it. Interacts with UBQLN2 and
CC       ubiquitin. {ECO:0000250|UniProtKB:Q16186}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16186}.
CC       Nucleus {ECO:0000250|UniProtKB:Q16186}.
CC   -!- DOMAIN: The Pru (pleckstrin-like receptor for ubiquitin) domain
CC       mediates interactions with PSMD1 and ubiquitin. Preferential
CC       binding to the proximal subunit of K48-linked diubiquitin allows
CC       UCHL5 access to the distal subunit.
CC       {ECO:0000250|UniProtKB:Q16186}.
CC   -!- SIMILARITY: Belongs to the ADRM1 family. {ECO:0000305}.
DR   EMBL; BT029893; ABM21559.1; -; mRNA.
DR   RefSeq; NP_001073751.1; NM_001080282.1.
DR   SMR; A1L5A6; -.
DR   STRING; 9913.ENSBTAP00000003974; -.
DR   PaxDb; A1L5A6; -.
DR   PeptideAtlas; A1L5A6; -.
DR   PRIDE; A1L5A6; -.
DR   Ensembl; ENSBTAT00000003974; ENSBTAP00000003974; ENSBTAG00000003058.
DR   GeneID; 519729; -.
DR   KEGG; bta:519729; -.
DR   CTD; 11047; -.
DR   VGNC; VGNC:25699; ADRM1.
DR   eggNOG; KOG3037; Eukaryota.
DR   eggNOG; ENOG410XSJJ; LUCA.
DR   GeneTree; ENSGT00390000013839; -.
DR   HOGENOM; HOG000005947; -.
DR   InParanoid; A1L5A6; -.
DR   KO; K06691; -.
DR   OMA; HCRRINE; -.
DR   OrthoDB; 1479349at2759; -.
DR   TreeFam; TF313410; -.
DR   Reactome; R-BTA-5689603; UCH proteinases.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000003058; Expressed in 9 organ(s), highest expression level in testis.
DR   ExpressionAtlas; A1L5A6; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 2.30.29.70; -; 1.
DR   Gene3D; 3.40.190.140; -; 1.
DR   InterPro; IPR006773; Rpn13/ADRM1.
DR   InterPro; IPR038633; Rpn13/ADRM1_sf.
DR   InterPro; IPR032368; RPN13_C.
DR   InterPro; IPR038108; RPN13_C_sf.
DR   PANTHER; PTHR12225; PTHR12225; 1.
DR   Pfam; PF04683; Proteasom_Rpn13; 1.
DR   Pfam; PF16550; RPN13_C; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Complete proteome; Cytoplasm; Isopeptide bond; Nucleus;
KW   Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation.
FT   INIT_MET      1      1       Removed. {ECO:0000250|UniProtKB:Q16186}.
FT   CHAIN         2    407       Proteasomal ubiquitin receptor ADRM1.
FT                                /FTId=PRO_0000286070.
FT   REGION        2    132       Interaction with PSMD1. {ECO:0000250}.
FT   REGION       22    130       Pru (pleckstrin-like receptor for
FT                                ubiquitin) domain.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   REGION      362    407       Interaction with UCHL5. {ECO:0000250}.
FT   COMPBIAS    135    199       Gly-rich.
FT   COMPBIAS    203    257       Ser-rich.
FT   MOD_RES       2      2       N-acetylthreonine.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   MOD_RES      15     15       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   MOD_RES     127    127       Phosphotyrosine.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   MOD_RES     140    140       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   MOD_RES     211    211       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   MOD_RES     217    217       Phosphothreonine.
FT                                {ECO:0000250|UniProtKB:Q16186}.
FT   MOD_RES     405    405       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9JMB5}.
FT   CROSSLNK     34     34       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT                                {ECO:0000250|UniProtKB:Q16186}.
SQ   SEQUENCE   407 AA;  41955 MW;  622F17326AD66E64 CRC64;
     MTTSGALFPS LVPGSRGSSN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC
     WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH
     CRKVNEYLNN PPMPGALGAS GSGGHELSAL GGEGGLQSLL GNMSHSQLMQ LIGPAGLGGL
     GGLGALTGPG LASLLGSGGP PASSSSSSSR SQSAAVTPSS TTSSTRATPA PSAPAAASAT
     SPSPAPSSGD GASTAASPAQ PIQLSDLQSI LATMSVPAGP GGGQQVDLAS VLTPEIMAPI
     LANADVQERL LPYLPSGESL PQTAEEIQNT LTSPQFQQAL GMFSAALASG QLGPLMCQFG
     LPAEAVEAAN KGDVEAFAKA MQNSASPEQQ EGDGKDKKDE EEDMSLD
//
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