GenomeNet

Database: UniProt
Entry: ADRM1_DANRE
LinkDB: ADRM1_DANRE
Original site: ADRM1_DANRE 
ID   ADRM1_DANRE             Reviewed;         410 AA.
AC   Q6NZ09;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   13-NOV-2019, entry version 98.
DE   RecName: Full=Proteasomal ubiquitin receptor ADRM1;
GN   Name=adrm1b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B.,
RA   den Hertog J., Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-
RT   scale analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: Functions as a proteasomal ubiquitin receptor. Promotes
CC       the deubiquitinating activity associated with the 26S proteasome
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the 26S proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- DOMAIN: The PH domain mediates interactions with PSMD1 and
CC       ubiquitin. Preferential binding to the proximal subunit of K48-
CC       linked diubiquitin allows UCHL5 access to the distal subunit (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ADRM1 family. {ECO:0000305}.
DR   EMBL; BC066391; AAH66391.1; -; mRNA.
DR   RefSeq; XP_005162020.1; XM_005161963.3.
DR   SMR; Q6NZ09; -.
DR   STRING; 7955.ENSDARP00000075874; -.
DR   iPTMnet; Q6NZ09; -.
DR   PaxDb; Q6NZ09; -.
DR   Ensembl; ENSDART00000180014; ENSDARP00000150387; ENSDARG00000058560.
DR   ZFIN; ZDB-GENE-040426-905; adrm1.
DR   eggNOG; KOG3037; Eukaryota.
DR   eggNOG; ENOG410XSJJ; LUCA.
DR   GeneTree; ENSGT00390000013839; -.
DR   HOGENOM; HOG000005947; -.
DR   InParanoid; Q6NZ09; -.
DR   Reactome; R-DRE-5689603; UCH proteinases.
DR   Reactome; R-DRE-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q6NZ09; -.
DR   Proteomes; UP000000437; Chromosome 23.
DR   ExpressionAtlas; Q6NZ09; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR   GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR   GO; GO:0070628; F:proteasome binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 2.30.29.70; -; 1.
DR   Gene3D; 3.40.190.140; -; 1.
DR   InterPro; IPR006773; Rpn13/ADRM1.
DR   InterPro; IPR038633; Rpn13/ADRM1_sf.
DR   InterPro; IPR032368; RPN13_C.
DR   InterPro; IPR038108; RPN13_C_sf.
DR   PANTHER; PTHR12225; PTHR12225; 1.
DR   Pfam; PF04683; Proteasom_Rpn13; 1.
DR   Pfam; PF16550; RPN13_C; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Proteasome;
KW   Reference proteome.
FT   CHAIN         1    410       Proteasomal ubiquitin receptor ADRM1.
FT                                /FTId=PRO_0000286071.
FT   DOMAIN       21    129       PH.
FT   COMPBIAS     12     19       Poly-Ser.
FT   COMPBIAS    134    194       Gly-rich.
FT   MOD_RES      18     18       Phosphoserine.
FT                                {ECO:0000269|PubMed:18307296}.
SQ   SEQUENCE   410 AA;  42596 MW;  0DF487D721BDF6A7 CRC64;
     MSSGALFPSL VSGSRSSSSK YLVEFRAGKM TLKGSTVTPD KRKGTVYIQQ TDDSLIHFCW
     KDRTSGNVED DLIIFPDDCE FKRVNQCTTG RVYVLKFKAG SKRLFFWMQE PKTDKDDEYC
     RKVNEYLNNP PMPGALGSGG GGGHELSALG EGGLQSLLGN MSHNQLMQLI GPTGLGGLGA
     LAGPGLASLL GSGGPATSSS TSSSRSQSAA ATPSSGSAAR LSSTQAPTTP VTPAATSSGS
     PTVTPTTPAA QTPSLPAGPA SSTQPIQLSD LQSILATMNV PAMPTEGSGV DLASVLTPDV
     MAPILANPEV QQRLLPYLPS GESLPQSAEE IQNTLTSPQF QQAMSMFSSA LASGQLGPLM
     NQFGLPSEAV DAANKGDVEA FAKAMEGSDS KTDDGDSKDK KDDDEDMSLD
//
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