ID AGRA_STAEQ Reviewed; 238 AA.
AC Q5HMY2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 24-JAN-2024, entry version 107.
DE RecName: Full=Accessory gene regulator protein A;
GN Name=agrA; OrderedLocusNames=SERP1493;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Required for high-level post-exponential phase expression of
CC a series of secreted proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW54824.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000029; AAW54824.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001829999.1; NC_002976.3.
DR AlphaFoldDB; Q5HMY2; -.
DR SMR; Q5HMY2; -.
DR STRING; 176279.SERP1493; -.
DR GeneID; 50018262; -.
DR KEGG; ser:SERP1493; -.
DR eggNOG; COG3279; Bacteria.
DR HOGENOM; CLU_000445_14_6_9; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR CDD; cd17533; REC_LytTR_AgrA-like; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.40.50.1020; LytTr DNA-binding domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR046947; LytR-like.
DR InterPro; IPR007492; LytTR_DNA-bd_dom.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR37299:SF3; STAGE 0 SPORULATION PROTEIN A HOMOLOG; 1.
DR PANTHER; PTHR37299; TRANSCRIPTIONAL REGULATOR-RELATED; 1.
DR Pfam; PF04397; LytTR; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00850; LytTR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR PROSITE; PS50930; HTH_LYTTR; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..238
FT /note="Accessory gene regulator protein A"
FT /id="PRO_0000081003"
FT DOMAIN 2..125
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 143..238
FT /note="HTH LytTR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00112"
FT MOD_RES 59
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 238 AA; 27937 MW; 32DF5EA3E59251E0 CRC64;
MKIFVCEDDQ RQREHMVSII KNYIMIEEKP MELALATNDP YEVLEQSKEL NDIGCYFLDI
QLEADMNGIK LASEIRKHDP VGNIIFVTSH SELTYLTFVY KVAAMDFIFK DDPSELKMRI
IDCLETAHTR LKLLSKESNV DTIELKRGSN SVYVQYDDIM FFESSTKSHR LIAHLDNRQI
EFYGNLKELA QLDERFFRCH NSFVINRHNI ESIDSKERIV YFKNGENCFA SVRNVKKI
//
