ID ANR55_MOUSE Reviewed; 626 AA.
AC Q8BLD6; E9QPX4; Q3UUM0; Q9CTM6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=Ankyrin repeat domain-containing protein 55;
GN Name=Ankrd55;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Corpora quadrigemina, Corpus striatum, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
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DR EMBL; AK021066; BAB32291.1; -; mRNA.
DR EMBL; AK045480; BAC32388.1; -; mRNA.
DR EMBL; AK138273; BAE23605.1; -; mRNA.
DR EMBL; AC154639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS26772.1; -.
DR RefSeq; NP_001161875.1; NM_001168403.1.
DR RefSeq; NP_084174.2; NM_029898.3.
DR RefSeq; XP_006517852.1; XM_006517789.2.
DR AlphaFoldDB; Q8BLD6; -.
DR SMR; Q8BLD6; -.
DR STRING; 10090.ENSMUSP00000022275; -.
DR iPTMnet; Q8BLD6; -.
DR PhosphoSitePlus; Q8BLD6; -.
DR jPOST; Q8BLD6; -.
DR PaxDb; 10090-ENSMUSP00000022275; -.
DR ProteomicsDB; 282004; -.
DR Antibodypedia; 62397; 57 antibodies from 17 providers.
DR DNASU; 77318; -.
DR Ensembl; ENSMUST00000022275.14; ENSMUSP00000022275.7; ENSMUSG00000049985.16.
DR GeneID; 77318; -.
DR KEGG; mmu:77318; -.
DR UCSC; uc007rwd.2; mouse.
DR AGR; MGI:1924568; -.
DR CTD; 79722; -.
DR MGI; MGI:1924568; Ankrd55.
DR VEuPathDB; HostDB:ENSMUSG00000049985; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00950000182908; -.
DR InParanoid; Q8BLD6; -.
DR OMA; VFCKAWT; -.
DR OrthoDB; 5348897at2759; -.
DR PhylomeDB; Q8BLD6; -.
DR TreeFam; TF315452; -.
DR BioGRID-ORCS; 77318; 0 hits in 77 CRISPR screens.
DR ChiTaRS; Ankrd55; mouse.
DR PRO; PR:Q8BLD6; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8BLD6; Protein.
DR Bgee; ENSMUSG00000049985; Expressed in spermatocyte and 39 other cell types or tissues.
DR ExpressionAtlas; Q8BLD6; baseline and differential.
DR Genevisible; Q8BLD6; MM.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24126:SF14; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10-RELATED; 1.
DR PANTHER; PTHR24126; ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..626
FT /note="Ankyrin repeat domain-containing protein 55"
FT /id="PRO_0000274411"
FT REPEAT 25..54
FT /note="ANK 1"
FT REPEAT 59..88
FT /note="ANK 2"
FT REPEAT 92..124
FT /note="ANK 3"
FT REPEAT 125..156
FT /note="ANK 4"
FT REPEAT 160..189
FT /note="ANK 5"
FT REPEAT 193..222
FT /note="ANK 6"
FT REPEAT 229..259
FT /note="ANK 7"
FT REPEAT 263..292
FT /note="ANK 8"
FT REPEAT 296..325
FT /note="ANK 9"
FT REGION 354..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 474
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT CONFLICT 464
FT /note="H -> N (in Ref. 1; BAC32388)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="V -> G (in Ref. 1; BAB32291)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 626 AA; 68524 MW; C3F6066166C709EE CRC64;
MRQATMDFST SSVFDQHKGD SSEEVDLAMV YQAASNGDVN SLTSVIREDP SILECCDSEG
CTPLMHAVSG RQVDTVKLLL KMGANINTQD AYGRTSLCLA TYLGWLEGCV SLLRNGAKHN
IPDKNGRLPL HAATAEPDVR LLIVLLQQSS LSEINHQDTE GMTPLHWAAF HNRPQHTQML
LKKGADPTLV DKDFKTALHW AVQSGNRILC SIILSHRQGP SIINYDDESG KTCVHIAAAS
GFGDIINDLA KVPECNLQAL DVDDRTPLHW AAASGKAECV QSLLDLGMDS NLRDINESTP
LAYALYCGHT ACVRLLSREG RAEPARPLPS QNSQPQKKEG RFSMLNQIFC KNKKEEQKAH
QKDQSRARPK EEETSEVNDI IATFDSVVDT NCQGQPGDQV DMVVFKKRTS ENSKYLLPEK
KSLARKGLPP IRTQSLPPIT LGGHFLTASQ GAVSHAGLNA GPQHTAQRSQ KSRSEQDLLN
NRTGCPVSLE NPWKGDTRQV FSCKAWTVSS SDKLLDRLFA GQPGHQELSG PPHLPHLHNP
SSGQALQHLS PNRPKIRDLP FTRNSLAPLP DQKFLSGEPL RTNRVLPAIP SQRGHDPSPA
GESQRGHDPP RAEESGGSSS PTHDEN
//
