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Database: UniProt
Entry: AP2S_ARATH
LinkDB: AP2S_ARATH
Original site: AP2S_ARATH 
ID   AP2S_ARATH              Reviewed;         142 AA.
AC   Q84WL9; Q9FZG3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=AP-2 complex subunit sigma;
DE   AltName: Full=Adaptor AP-2 17 kDa protein;
DE   AltName: Full=Adaptor-related protein complex 2 subunit sigma;
DE   AltName: Full=Clathrin assembly protein 2 small chain;
DE   AltName: Full=Clathrin coat assembly protein AP17;
DE   AltName: Full=Clathrin coat-associated protein AP17;
DE   AltName: Full=Sigma2-adaptin;
GN   Name=AP17; OrderedLocusNames=At1g47830; ORFNames=T2E6.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND REVIEW.
RX   PubMed=11598180; DOI=10.1091/mbc.12.10.2907;
RA   Boehm M., Bonifacino J.S.;
RT   "Adaptins: the final recount.";
RL   Mol. Biol. Cell 12:2907-2920(2001).
CC   -!- FUNCTION: Subunit of the adaptor protein complex 2 (AP-2). Adaptor
CC       protein complexes function in protein transport via transport vesicles
CC       in different membrane traffic pathways. Adaptor protein complexes are
CC       vesicle coat components and appear to be involved in cargo selection
CC       and vesicle formation. AP-2 is involved in clathrin-dependent
CC       endocytosis in which cargo proteins are incorporated into vesicles
CC       surrounded by clathrin (clathrin-coated vesicles, CCVs) which are
CC       destined for fusion with the early endosome. The complex binds
CC       polyphosphoinositides (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer composed
CC       of two large adaptins (alpha-type and beta-type subunits), a medium
CC       adaptin (mu-type subunit) and a small adaptin (sigma-type subunit).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane. Membrane, coated pit
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Component of the coat surrounding the
CC       cytoplasmic face of coated vesicles in the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF99787.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC012463; AAF99787.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE32220.1; -; Genomic_DNA.
DR   EMBL; BT003048; AAO23613.1; -; mRNA.
DR   EMBL; AK227317; BAE99331.1; -; mRNA.
DR   PIR; H96518; H96518.
DR   RefSeq; NP_175219.1; NM_103681.5.
DR   AlphaFoldDB; Q84WL9; -.
DR   SMR; Q84WL9; -.
DR   BioGRID; 26424; 7.
DR   IntAct; Q84WL9; 1.
DR   STRING; 3702.Q84WL9; -.
DR   iPTMnet; Q84WL9; -.
DR   PaxDb; 3702-AT1G47830-1; -.
DR   ProteomicsDB; 244483; -.
DR   EnsemblPlants; AT1G47830.1; AT1G47830.1; AT1G47830.
DR   GeneID; 841199; -.
DR   Gramene; AT1G47830.1; AT1G47830.1; AT1G47830.
DR   KEGG; ath:AT1G47830; -.
DR   Araport; AT1G47830; -.
DR   TAIR; AT1G47830; AP2S.
DR   eggNOG; KOG0935; Eukaryota.
DR   HOGENOM; CLU_061221_3_2_1; -.
DR   InParanoid; Q84WL9; -.
DR   OMA; QSNFVEY; -.
DR   OrthoDB; 21148at2759; -.
DR   PhylomeDB; Q84WL9; -.
DR   PRO; PR:Q84WL9; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q84WL9; baseline and differential.
DR   Genevisible; Q84WL9; AT.
DR   GO; GO:0030122; C:AP-2 adaptor complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; HDA:TAIR.
DR   GO; GO:0035615; F:clathrin adaptor activity; IEA:InterPro.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd14833; AP2_sigma; 1.
DR   Gene3D; 3.30.450.60; -; 1.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027156; APS2.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR   PANTHER; PTHR11753:SF6; AP-2 COMPLEX SUBUNIT SIGMA; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SNARE-like; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coated pit; Endocytosis; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..142
FT                   /note="AP-2 complex subunit sigma"
FT                   /id="PRO_0000397858"
SQ   SEQUENCE   142 AA;  17067 MW;  184F456553204042 CRC64;
     MIRFILLQNR QGKTRLAKYY VPLEESEKHK VEYEVHRLVV NRDAKFTNFV EFRTHKVIYR
     RYAGLFFSVC VDITDNELAY LESIHLFVEI LDHFFSNVCE LDLVFNFHKV YLILDEFILA
     GELQETSKRA IIERMSELEK LQ
//
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