ID APGM2_METTH Reviewed; 402 AA.
AC O26518;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2;
DE Short=BPG-independent PGAM 2;
DE Short=Phosphoglyceromutase 2;
DE Short=aPGAM 2;
DE EC=5.4.2.12;
GN Name=apgM2; OrderedLocusNames=MTH_418;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: Catalyzes the interconversion of 2-phosphoglycerate and 3-
CC phosphoglycerate. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate;
CC Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289;
CC EC=5.4.2.12;
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 3/5.
CC -!- SIMILARITY: Belongs to the BPG-independent phosphoglycerate mutase
CC family. A-PGAM subfamily. {ECO:0000305}.
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DR EMBL; AE000666; AAB84924.1; -; Genomic_DNA.
DR PIR; D69154; D69154.
DR AlphaFoldDB; O26518; -.
DR SMR; O26518; -.
DR STRING; 187420.MTH_418; -.
DR PaxDb; 187420-MTH_418; -.
DR EnsemblBacteria; AAB84924; AAB84924; MTH_418.
DR KEGG; mth:MTH_418; -.
DR PATRIC; fig|187420.15.peg.388; -.
DR HOGENOM; CLU_034906_2_0_2; -.
DR InParanoid; O26518; -.
DR BioCyc; MetaCyc:MONOMER-14535; -.
DR UniPathway; UPA00109; UER00186.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0046537; F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16011; iPGM_like; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR HAMAP; MF_01402_A; ApgM_A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR023665; ApgAM_prokaryotes.
DR InterPro; IPR006124; Metalloenzyme.
DR InterPro; IPR004456; Pglycerate_mutase_ApgM.
DR NCBIfam; TIGR00306; apgM; 1.
DR NCBIfam; TIGR02535; hyp_Hser_kinase; 1.
DR PANTHER; PTHR31209:SF4; 2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE; 1.
DR PANTHER; PTHR31209; COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE; 1.
DR Pfam; PF01676; Metalloenzyme; 1.
DR Pfam; PF10143; PhosphMutase; 1.
DR PIRSF; PIRSF006392; IPGAM_arch; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Glycolysis; Isomerase; Reference proteome.
FT CHAIN 1..402
FT /note="2,3-bisphosphoglycerate-independent phosphoglycerate
FT mutase 2"
FT /id="PRO_0000138140"
SQ SEQUENCE 402 AA; 44100 MW; EB5EF3B8A18E7617 CRC64;
MITMKHVILV GDGMADYPLD ELDGKTPLQV ADKPNMDQLA GMGACGLLRT VPEGMEAGSD
VANLSIMGYD PRRYYTGRGP LEAASIGVEL GDDDVAFRCN LINADERIVD FNAGHIETAE
ASSLIDALNH ELETRGRFYA GVSYRNLFVI EGRGYTSVRV EPPHDIVGES VAAHLPSGSE
EADHIRELML ESAGVLRSHE VNLKRESMGK RPATMIWLWG QGLRPSMEPF SERYGIRGAT
ITAVDLIKGL GVYAGLENIH VPGATGYLDT DYRAKGRYAA GALEEYDFLY VHVEAPDEAG
HAGDAEEKIR AIENIDRFVL GRLLDALSDH EHRIAVLPDH PTPIEIRTHV PDPVPCILAG
DGVDADQVKS YDEFTVREGS LGTWEAHRLM EIMMDPAARL RQ
//
