ID APO1B_PONAB Reviewed; 65 AA.
AC P0CE40;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Apolipoprotein C-I, basic form;
DE Short=Apo-CIB;
DE Short=ApoC-IB;
DE AltName: Full=Apolipoprotein C1B;
DE Contains:
DE RecName: Full=Cholesteryl ester transfer inhibitor protein;
DE Short=CETIP;
DE Flags: Precursor;
GN Name=APOC1B;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=20209111; DOI=10.1016/j.cbd.2009.12.003;
RA Puppione D.L., Ryan C.M., Bassilian S., Souda P., Xiao X., Ryder O.A.,
RA Whitelegge J.P.;
RT "Detection of two distinct forms of apoC-I in great apes.";
RL Comp. Biochem. Physiol. 5D:73-79(2010).
RN [3]
RP REVIEW.
RX PubMed=28757862; DOI=10.1007/s11515-013-1278-7;
RA Puppione D., Whitelegge J.P.;
RT "Proteogenomic Review of the Changes in Primate apoC-I during Evolution.";
RL Front. Biol. 8:533-548(2013).
RN [4]
RP GENE DUPLICATION.
RX PubMed=25160599; DOI=10.1016/j.cbd.2014.08.001;
RA Puppione D.L.;
RT "Higher primates, but not New World monkeys, have a duplicate set of
RT enhancers flanking their apoC-I genes.";
RL Comp. Biochem. Physiol. 11:45-48(2014).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC -!- MISCELLANEOUS: Apolipoprotein C-I is present in acidic (APOC1A) and
CC basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and
CC perhaps also in baboons and macaques. The two genes for ApoC-I arose
CC through a duplication process that occurred after the divergence of New
CC World monkeys from the human lineage. In human, the acidic form has
CC become a pseudogene sometime between the divergence of bonobos and
CC chimpanzees from the human lineage and the appearance of the
CC Denisovans. Pseudogenization resulted when the codon for the
CC penultimate amino acid in the signal sequence was changed to a stop
CC codon. {ECO:0000303|PubMed:25160599}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR AlphaFoldDB; P0CE40; -.
DR SMR; P0CE40; -.
DR eggNOG; ENOG502SEU4; Eukaryota.
DR HOGENOM; CLU_160094_1_0_1; -.
DR InParanoid; P0CE40; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 4.10.260.30; Apolipoprotein C-I; 1.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR PANTHER; PTHR16565; APOLIPOPROTEIN C-I; 1.
DR PANTHER; PTHR16565:SF2; APOLIPOPROTEIN C-I; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 3: Inferred from homology;
KW Lipid transport; Reference proteome; Secreted; Signal; Transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..65
FT /note="Apolipoprotein C-I, basic form"
FT /id="PRO_0000391840"
FT CHAIN 29..65
FT /note="Cholesteryl ester transfer inhibitor protein"
FT /evidence="ECO:0000250|UniProtKB:P34929"
FT /id="PRO_0000391841"
SQ SEQUENCE 65 AA; 7078 MW; 260E1BE8BDDBDF37 CRC64;
MRLFLSLPVL VVVLSMVLEG PAPAQGAPDV SSALDKLKEF GNTLEDKARE VINRIKQSEL
SAKTR
//
