ID APOA1_TURTR Reviewed; 265 AA.
AC P0DMB0;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Apolipoprotein A-I;
DE Short=Apo-AI;
DE Short=ApoA-I;
DE AltName: Full=Apolipoprotein A1;
DE Contains:
DE RecName: Full=Proapolipoprotein A-I;
DE Short=ProapoA-I;
DE Contains:
DE RecName: Full=Truncated apolipoprotein A-I;
DE Flags: Precursor;
GN Name=APOA1;
OS Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Delphinidae; Tursiops.
OX NCBI_TaxID=9739;
RN [1]
RP IDENTIFICATION.
RA Puppione D.L.;
RL Unpublished observations (NOV-2013).
CC -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC tissues to the liver for excretion by promoting cholesterol efflux from
CC tissues and by acting as a cofactor for the lecithin cholesterol
CC acyltransferase (LCAT). As part of the SPAP complex, activates
CC spermatozoa motility (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with APOA1BP and CLU.
CC Component of a sperm activating protein complex (SPAP), consisting of
CC APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and
CC albumin. Interacts with NDRG1. Interacts with SCGB3A2 (By similarity).
CC Interacts with NAXE and YJEFN3 (By similarity).
CC {ECO:0000250|UniProtKB:G5BQH5, ECO:0000250|UniProtKB:P02647,
CC ECO:0000250|UniProtKB:P04639}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Major protein of plasma HDL, also found in
CC chylomicrons.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- PTM: Palmitoylated. {ECO:0000250}.
CC -!- PTM: Phosphorylation sites are present in the extracellular medium.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC {ECO:0000305}.
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DR RefSeq; XP_019797580.1; XM_019942021.1.
DR AlphaFoldDB; P0DMB0; -.
DR SMR; P0DMB0; -.
DR STRING; 9739.ENSTTRP00000010994; -.
DR GeneID; 101324813; -.
DR InParanoid; P0DMB0; -.
DR OrthoDB; 5310876at2759; -.
DR Proteomes; UP000245320; Chromosome 8.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR GO; GO:0010875; P:positive regulation of cholesterol efflux; ISS:UniProtKB.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:1902995; P:positive regulation of phospholipid efflux; ISS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR Gene3D; 1.20.5.20; -; 1.
DR Gene3D; 6.10.140.380; -; 1.
DR Gene3D; 1.20.120.20; Apolipoprotein; 1.
DR InterPro; IPR000074; ApoA_E.
DR PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR PANTHER; PTHR18976:SF11; APOLIPOPROTEIN A-I; 1.
DR Pfam; PF01442; Apolipoprotein; 1.
DR SUPFAM; SSF58113; Apolipoprotein A-I; 1.
PE 2: Evidence at transcript level;
KW Cholesterol metabolism; Glycoprotein; HDL; Lipid metabolism;
KW Lipid transport; Lipoprotein; Oxidation; Palmitate; Phosphoprotein;
KW Reference proteome; Repeat; Secreted; Signal; Steroid metabolism;
KW Sterol metabolism; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000250"
FT CHAIN 19..265
FT /note="Proapolipoprotein A-I"
FT /id="PRO_0000425339"
FT CHAIN 25..265
FT /note="Apolipoprotein A-I"
FT /id="PRO_0000425101"
FT CHAIN 25..264
FT /note="Truncated apolipoprotein A-I"
FT /id="PRO_0000425102"
FT REPEAT 67..88
FT /note="1"
FT REPEAT 89..110
FT /note="2"
FT REPEAT 111..121
FT /note="3; half-length"
FT REPEAT 122..142
FT /note="4"
FT REPEAT 144..165
FT /note="5"
FT REPEAT 166..187
FT /note="6"
FT REPEAT 188..209
FT /note="7"
FT REPEAT 210..230
FT /note="8"
FT REPEAT 231..241
FT /note="9; half-length"
FT REPEAT 242..265
FT /note="10"
FT REGION 67..265
FT /note="10 X approximate tandem repeats"
FT /evidence="ECO:0000250"
FT MOD_RES 109
FT /note="Methionine sulfoxide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 265 AA; 30374 MW; B5AC1FCAF067DD54 CRC64;
MKAVLLTLAV LFLTGSQARH FWQQDDPQSS WDRVKDFATV YVDAIKDSGR DYVAQFEASA
LGKQLNLKLL DNWDSLTSTF AKVREQLGPV TQEFWDNLEK ETESLRQEMN KDLEEVKQKV
QPYLDEFQKK WQEELQIYRQ KVAPLGEELR EGARQKVQEL QDKLTPLAEE MRDRARSHVE
TLRQQLAPYS DDLRQRMAAR FEMLKAGGGS LAEYHAKASE QLRALGEKAK PALEDLRQGL
VPVLESLKVS ILAAIDEASK KLNAQ
//
