ID ARFRP_BOVIN Reviewed; 201 AA.
AC Q32LJ2;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=ADP-ribosylation factor-related protein 1;
DE Short=ARF-related protein 1;
GN Name=ARFRP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting.
CC Controls the targeting of ARL1 and its effector to the trans-Golgi.
CC Required for the lipidation of chylomicrons in the intestine and
CC required for VLDL lipidation in the liver.
CC {ECO:0000250|UniProtKB:Q8BXL7}.
CC -!- SUBUNIT: Interacts with SYS1. {ECO:0000250|UniProtKB:Q13795}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus. Golgi apparatus, trans-Golgi
CC network {ECO:0000250|UniProtKB:Q8BXL7}. Note=Located in the trans-Golgi
CC in the GTP-bound active state. {ECO:0000250|UniProtKB:Q8BXL7}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000305}.
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DR EMBL; BC109550; AAI09551.1; -; mRNA.
DR RefSeq; NP_001032696.1; NM_001037607.1.
DR AlphaFoldDB; Q32LJ2; -.
DR SMR; Q32LJ2; -.
DR STRING; 9913.ENSBTAP00000009858; -.
DR PaxDb; 9913-ENSBTAP00000009858; -.
DR Ensembl; ENSBTAT00000009858.4; ENSBTAP00000009858.3; ENSBTAG00000007497.4.
DR GeneID; 525394; -.
DR KEGG; bta:525394; -.
DR CTD; 10139; -.
DR VEuPathDB; HostDB:ENSBTAG00000007497; -.
DR VGNC; VGNC:26069; ARFRP1.
DR eggNOG; KOG0076; Eukaryota.
DR GeneTree; ENSGT00940000156407; -.
DR HOGENOM; CLU_040729_7_2_1; -.
DR InParanoid; Q32LJ2; -.
DR OMA; HGFYKYM; -.
DR OrthoDB; 5349301at2759; -.
DR TreeFam; TF105788; -.
DR Reactome; R-BTA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000007497; Expressed in digestive system secreted substance and 104 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; IBA:GO_Central.
DR CDD; cd04160; Arfrp1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45909; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR45909:SF1; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Golgi apparatus; GTP-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..201
FT /note="ADP-ribosylation factor-related protein 1"
FT /id="PRO_0000245356"
FT BINDING 24..31
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 75..79
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 134..137
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q13795"
SQ SEQUENCE 201 AA; 22644 MW; F1CBFD139A73520A CRC64;
MYTLLSGLYK YMFQKDEYCV LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN
IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLSE SKQAFEKMVT
SEALDGVPIL VLANKQDVET CLSIPDIKTA FSDCASKIGR RDCLTQACSA LTGKGVREGI
EWMVKCVVRN VHRPPRQRDI T
//
