ID ARMX2_MOUSE Reviewed; 784 AA.
AC Q6A058; A2AKS5; Q9CXI9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 24-JAN-2024, entry version 136.
DE RecName: Full=Armadillo repeat-containing X-linked protein 2;
GN Name=Armcx2; Synonyms=Kiaa0512;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22569362; DOI=10.1038/ncomms1829;
RA Lopez-Domenech G., Serrat R., Mirra S., D'Aniello S., Somorjai I., Abad A.,
RA Vitureira N., Garcia-Arumi E., Alonso M.T., Rodriguez-Prados M.,
RA Burgaya F., Andreu A.L., Garcia-Sancho J., Trullas R., Garcia-Fernandez J.,
RA Soriano E.;
RT "The eutherian Armcx genes regulate mitochondrial trafficking in neurons
RT and interact with Miro and Trak2.";
RL Nat. Commun. 3:814-814(2012).
CC -!- FUNCTION: May regulate the dynamics and distribution of mitochondria in
CC neural cells. {ECO:0000269|PubMed:22569362}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22569362}.
CC Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8BHS6}; Single-
CC pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Widely expressed in the adult nervous tissue,
CC especially in the forebrain, including the cerebral cortex, hippocampus
CC and thalamus. {ECO:0000269|PubMed:22569362}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32238.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK172960; BAD32238.1; ALT_INIT; mRNA.
DR EMBL; AK014329; BAB29276.1; -; mRNA.
DR EMBL; AK034185; BAC28622.1; -; mRNA.
DR EMBL; AK044926; BAC32145.1; -; mRNA.
DR EMBL; AL772348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC054839; AAH54839.1; -; mRNA.
DR CCDS; CCDS30401.1; -.
DR RefSeq; NP_001159869.1; NM_001166397.1.
DR RefSeq; NP_001159870.1; NM_001166398.1.
DR RefSeq; NP_080415.3; NM_026139.4.
DR RefSeq; XP_006528663.1; XM_006528600.1.
DR RefSeq; XP_006528665.1; XM_006528602.1.
DR RefSeq; XP_006528666.1; XM_006528603.1.
DR AlphaFoldDB; Q6A058; -.
DR SMR; Q6A058; -.
DR STRING; 10090.ENSMUSP00000127305; -.
DR GlyGen; Q6A058; 4 sites, 1 O-linked glycan (4 sites).
DR iPTMnet; Q6A058; -.
DR PhosphoSitePlus; Q6A058; -.
DR EPD; Q6A058; -.
DR MaxQB; Q6A058; -.
DR PaxDb; 10090-ENSMUSP00000108818; -.
DR PeptideAtlas; Q6A058; -.
DR ProteomicsDB; 277305; -.
DR Pumba; Q6A058; -.
DR Antibodypedia; 28782; 173 antibodies from 26 providers.
DR DNASU; 67416; -.
DR Ensembl; ENSMUST00000035559.11; ENSMUSP00000049147.5; ENSMUSG00000033436.14.
DR Ensembl; ENSMUST00000113193.9; ENSMUSP00000108818.3; ENSMUSG00000033436.14.
DR Ensembl; ENSMUST00000119010.8; ENSMUSP00000112507.2; ENSMUSG00000033436.14.
DR Ensembl; ENSMUST00000168264.2; ENSMUSP00000127305.2; ENSMUSG00000033436.14.
DR GeneID; 67416; -.
DR KEGG; mmu:67416; -.
DR UCSC; uc009ugq.2; mouse.
DR AGR; MGI:1914666; -.
DR CTD; 9823; -.
DR MGI; MGI:1914666; Armcx2.
DR VEuPathDB; HostDB:ENSMUSG00000033436; -.
DR eggNOG; ENOG502QQ2D; Eukaryota.
DR GeneTree; ENSGT00940000163008; -.
DR HOGENOM; CLU_028273_0_0_1; -.
DR InParanoid; Q6A058; -.
DR OMA; YNYREFN; -.
DR OrthoDB; 2912889at2759; -.
DR PhylomeDB; Q6A058; -.
DR TreeFam; TF335652; -.
DR BioGRID-ORCS; 67416; 0 hits in 77 CRISPR screens.
DR ChiTaRS; Armcx2; mouse.
DR PRO; PR:Q6A058; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6A058; Protein.
DR Bgee; ENSMUSG00000033436; Expressed in indifferent gonad and 250 other cell types or tissues.
DR Genevisible; Q6A058; MM.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR15712; ARMADILLO REPEAT CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15712:SF9; ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 2; 1.
DR Pfam; PF04826; Arm_2; 1.
DR SMART; SM00185; ARM; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..784
FT /note="Armadillo repeat-containing X-linked protein 2"
FT /id="PRO_0000191365"
FT TOPO_DOM 1..6
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT TRANSMEM 7..27
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..784
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT REPEAT 528..568
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 570..609
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 650..689
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REGION 1..6
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305|PubMed:22569362"
FT REGION 26..40
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305|PubMed:22569362"
FT REGION 328..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 81036 MW; 3EEE7DB7EE6B0086 CRC64;
MSRARDAGCV AAGIVIGASA WYCVYKYTRG KDQKKKRLTK PKNRASVGTG SRARAGLRAG
FTIDLGPGFS PPNPVDIEIM NKAQGEASNL ATTVAEEVAP AAPSPKVQNG AESKVQELNG
AKTEANLESV VMPSATCTVT PPPKVAGGLT AAEAPEIIGA PKVLEAPSTT EASGAVAAPG
PTVSPMIAQT PGPVVPSPTI VSTGPAAIPW AVAHPGAVQS PGPAVPPMAV QSLVPAAPSW
AVVAPPGAVY IPVAAHFAGP AAASRVTQSP GTVIPPLPPP SSVLPRGVPS VPGRTVQSPG
AAVHPVAAQS TGVVVPPRAV QYSGAAVTSG GAAVPSGGAA TPRAAASTQR TASTEVMQVP
RVAAATEATE TPRIGTPAMV AEASLPVHSG AAENPGTSGS SKTAATGKKA APGAHTGAIP
KAGSATGAVP KGGGGKGGNK NRSGGKGKNR KNKVDVDELG MGFRPGDGAA AAAAASANGG
QAFLAEIPES EEGESGWTDT ESDSDSEPDV PQRGKGKRTI PMHKRPFPYE IDEILGVRDL
RKVLALLQKS DDPFIQQVAL LTLSNNANYS CNQETIRKLG GLPIIANMIN KTDPHIKEKA
LMAMNNLSEN YENQGRLQVY MNKVMDDIMA SNLNSAVQVV GLKFLTNMTI TNDYQHLLVN
SIANFFRLLS QGGGKIKVEI LKILSNFAEN PDMLKKLLGT QVPSSFSSLY NSYVESEILI
NALTLFEIIF DNLRAEVFNY REFNKGSLFY LCTTSGVCVK KIRALANHHD LLVKVKVIKL
VNKF
//
