ID ARP4_KLULA Reviewed; 520 AA.
AC Q6CSB9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Actin-related protein 4;
DE AltName: Full=Actin-like protein ARP4;
DE Short=Actin-like protein 4;
GN Name=ARP4; OrderedLocusNames=KLLA0D02288g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Chromatin interaction component of the NuA4 histone
CC acetyltransferase complex which is involved in transcriptional
CC activation of selected genes principally by acetylation of nucleosomal
CC histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is
CC required for NuA4 complex integrity. Component of the SWR1 complex
CC which mediates the ATP-dependent exchange of histone H2A for the H2A
CC variant HZT1 leading to transcriptional regulation of selected genes by
CC chromatin remodeling. Component of the INO80 complex which remodels
CC chromatin by shifting nucleosomes and is involved in DNA repair (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex, of
CC the INO80 chromatin remodeling complex, and of the SWR1 chromatin
CC remodeling complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. ARP4 subfamily. {ECO:0000305}.
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DR EMBL; CR382124; CAH00266.1; -; Genomic_DNA.
DR RefSeq; XP_453170.1; XM_453170.1.
DR AlphaFoldDB; Q6CSB9; -.
DR SMR; Q6CSB9; -.
DR STRING; 284590.Q6CSB9; -.
DR PaxDb; 284590-Q6CSB9; -.
DR GeneID; 2892798; -.
DR KEGG; kla:KLLA0_D02288g; -.
DR eggNOG; KOG0679; Eukaryota.
DR HOGENOM; CLU_027965_6_2_1; -.
DR InParanoid; Q6CSB9; -.
DR OMA; HNDYVPL; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 3.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF567; ACTIN-RELATED PROTEIN 4; 1.
DR Pfam; PF00022; Actin; 2.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..520
FT /note="Actin-related protein 4"
FT /id="PRO_0000089098"
FT REGION 320..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 57976 MW; F07C5E5E76BF45EA CRC64;
MSNPALQVYG GDEINAIVID PGSFVTNIGY SGTDCPQSIM PSSYGNVETD GDTKRIFNEQ
PLLFPRAGME IKPIVENSTI VDWDRAQEQW EYALNTDLKF ESNKGTPVLL TEPIWNSEAS
RKKSLEILLE SMEFEACYLA ANSSAVSFAM GRPTCLVVDI GHDVSTVSPV IDGMTLSKSS
TRNYVAGKYL NHLIAKNLKP REIVPIFQVL KKKPDFVKRT LSFDVNESVI NFANERQFFQ
EFKETLLHIA PKSLSSFKDE LATQTKRSLE APWGEELIFD ADTRYSFAEQ LFRPVKEDFP
EGWPASTDGI VKTWHNDYVP LKRTKPGTST NTKEKENTAE STPVPASTEQ EAVDSPSQEP
NENGKRPVEN KEDSSNNEQN SNEIKNEDAN SNESSAKATV PSNGIQAKGE DEVAGIVDLI
NKSMMEADVD LRATLAHNVV LTGGTSKIPG LSDRIMHELN KSLPALKFRM LSSGHLRERQ
YQGWLGGSIL ASLGTFHQLW VGREEYEEVG PERLLKDRFR
//
