ID ARRD3_BOVIN Reviewed; 414 AA.
AC Q0VCA2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Arrestin domain-containing protein 3;
GN Name=ARRDC3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein that plays a role in regulating cell-surface
CC expression of adrenergic receptors and probably also other G protein-
CC coupled receptors. Plays a role in NEDD4-mediated ubiquitination and
CC endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May
CC recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein
CC that does not play a major role in recruiting NEDD4 to ADRB2, but
CC rather plays a role in a targeting ADRB2 to endosomes.
CC {ECO:0000250|UniProtKB:Q96B67}.
CC -!- SUBUNIT: Interacts (via PPxY motifs) with NEDD4 (via WW domains).
CC Interacts with ADRB2. Interacts with ADRB3. Interacts with HGS (via
CC PPxY motifs). Does not bind TXN (thioredoxin). Interacts with ITCH.
CC {ECO:0000250|UniProtKB:Q96B67}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B67}. Cell
CC membrane {ECO:0000250|UniProtKB:Q96B67}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q96B67}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q96B67}. Lysosome
CC {ECO:0000250|UniProtKB:Q96B67}. Endosome
CC {ECO:0000250|UniProtKB:Q96B67}. Early endosome
CC {ECO:0000250|UniProtKB:Q96B67}. Note=Associated with plasma membrane,
CC as well as with endosomes and lysosomes during endocytosis.
CC {ECO:0000250|UniProtKB:Q96B67}.
CC -!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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DR EMBL; BC120276; AAI20277.1; -; mRNA.
DR RefSeq; NP_001069725.1; NM_001076257.2.
DR AlphaFoldDB; Q0VCA2; -.
DR SMR; Q0VCA2; -.
DR STRING; 9913.ENSBTAP00000009364; -.
DR PaxDb; 9913-ENSBTAP00000009364; -.
DR Ensembl; ENSBTAT00000009364.6; ENSBTAP00000009364.5; ENSBTAG00000007116.6.
DR GeneID; 541123; -.
DR KEGG; bta:541123; -.
DR CTD; 57561; -.
DR VEuPathDB; HostDB:ENSBTAG00000007116; -.
DR VGNC; VGNC:26173; ARRDC3.
DR eggNOG; KOG3780; Eukaryota.
DR GeneTree; ENSGT00940000155411; -.
DR HOGENOM; CLU_039221_1_1_1; -.
DR InParanoid; Q0VCA2; -.
DR OMA; IHAGRHE; -.
DR OrthoDB; 22053at2759; -.
DR TreeFam; TF313650; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000007116; Expressed in myometrium and 106 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031699; F:beta-3 adrenergic receptor binding; IEA:Ensembl.
DR GO; GO:0060613; P:fat pad development; IEA:Ensembl.
DR GO; GO:0031649; P:heat generation; IEA:Ensembl.
DR GO; GO:0071878; P:negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0031651; P:negative regulation of heat generation; IEA:Ensembl.
DR GO; GO:0090327; P:negative regulation of locomotion involved in locomotory behavior; IEA:Ensembl.
DR GO; GO:0035332; P:positive regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11188; ARRESTIN DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11188:SF49; ARRESTIN DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; E set domains; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Endosome; Lysosome; Membrane; Reference proteome;
KW Repeat.
FT CHAIN 1..414
FT /note="Arrestin domain-containing protein 3"
FT /id="PRO_0000282340"
FT REGION 393..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 346..349
FT /note="PPxY motif 1"
FT /evidence="ECO:0000305"
FT MOTIF 391..394
FT /note="PPxY motif 2"
FT /evidence="ECO:0000305"
SQ SEQUENCE 414 AA; 46370 MW; EC1714EC0DFB11CA CRC64;
MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT
ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFNTIHSGRH EYAFSFELPQ
TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT
LYCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM
KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD
LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLGLSLP ERPEAPPSYA EVVTEEQRRN
NLAPGSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQPADDRPS CPSR
//
