ID ATG17_NEOFI Reviewed; 550 AA.
AC A1DHW5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Autophagy-related protein 17;
GN Name=atg17; ORFNames=NFIA_089290;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Autophagy-specific protein that functions in response to
CC autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC timing and magnitude of the autophagy response, such as the size of the
CC sequestering vesicles. Plays particularly a role in pexophagy and
CC nucleophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC structure membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR EMBL; DS027696; EAW18972.1; -; Genomic_DNA.
DR RefSeq; XP_001260869.1; XM_001260868.1.
DR AlphaFoldDB; A1DHW5; -.
DR SMR; A1DHW5; -.
DR STRING; 331117.A1DHW5; -.
DR EnsemblFungi; EAW18972; EAW18972; NFIA_089290.
DR GeneID; 4587427; -.
DR KEGG; nfi:NFIA_089290; -.
DR VEuPathDB; FungiDB:NFIA_089290; -.
DR eggNOG; ENOG502RYHP; Eukaryota.
DR HOGENOM; CLU_028356_0_0_1; -.
DR OMA; THVWRAN; -.
DR OrthoDB; 1940609at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR InterPro; IPR007240; Atg17.
DR InterPro; IPR045326; ATG17-like_dom.
DR PANTHER; PTHR28005; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR PANTHER; PTHR28005:SF1; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR Pfam; PF04108; ATG17_like; 1.
PE 3: Inferred from homology;
KW Autophagy; Coiled coil; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..550
FT /note="Autophagy-related protein 17"
FT /id="PRO_0000317984"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 317..354
FT /evidence="ECO:0000255"
FT COILED 427..451
FT /evidence="ECO:0000255"
SQ SEQUENCE 550 AA; 60647 MW; DC9C599347F8D55F CRC64;
MSSSESSSAS GGGRPDAGQP PSEEQAMPRL DTLISHLVAA KRSLSSINHV WRANEIVTAA
RAALEECVVV SARTGFLRRG LNNQLRLLYS VRTEVEEISL RGRSEFAAVL KDLDDADTRL
RRTLELLRET IVHPAFRPEG EDPKSLHDFV DERGVEELHA ALKSSIDRTT AAQAQLDSSN
HAFDDELLSI KEALGTYRTA AKLASSRSSS SASSSSASNS SLPSMSTMPS MLHSLEMHAQ
EMANLLESLV RHFDLCVTAV KHTEGGGAAA KSITGDMPVG VPVSGRMGSN IEDINDNLNA
PLDPLSNSEY QEMVNVLFKD AAEAEDVVME IQDRISEMES VLENVLAQRD ALRSIYNATT
DIYQHLSSLG STRLPGYIAQ AHNFTQVWHE ENDRISGGLA DLSDLNSLYD GFLDAYDGLI
VEVARRKHVR QRVEKVLRDA RHKLDQLYEE DVTARETFRV EKGDYLPSDI WPEIGREPMR
IEFRRISGAN VQAVNLQRPH EQEAITGEQE AANRLAPVES SDGDEIIPDL PRDLVEQAFA
RLKARVKGAT
//
