ID ATG17_SCLS1 Reviewed; 492 AA.
AC A7EM16;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Autophagy-related protein 17;
GN Name=atg17; ORFNames=SS1G_06363;
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: Autophagy-specific protein that functions in response to
CC autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC to organize pre-autophagosomal structure (PAS) formation. Modulates the
CC timing and magnitude of the autophagy response, such as the size of the
CC sequestering vesicles. Plays particularly a role in pexophagy and
CC nucleophagy (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC structure membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATG17 family. {ECO:0000305}.
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DR EMBL; CH476628; EDO03882.1; -; Genomic_DNA.
DR RefSeq; XP_001592124.1; XM_001592074.1.
DR AlphaFoldDB; A7EM16; -.
DR SMR; A7EM16; -.
DR STRING; 665079.A7EM16; -.
DR GeneID; 5488443; -.
DR KEGG; ssl:SS1G_06363; -.
DR VEuPathDB; FungiDB:sscle_13g092360; -.
DR InParanoid; A7EM16; -.
DR OMA; THVWRAN; -.
DR OrthoDB; 1940609at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:1990316; C:Atg1/ULK1 kinase complex; IBA:GO_Central.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0044804; P:nucleophagy; IBA:GO_Central.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR InterPro; IPR007240; Atg17.
DR InterPro; IPR045326; ATG17-like_dom.
DR PANTHER; PTHR28005; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR PANTHER; PTHR28005:SF1; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR Pfam; PF04108; ATG17_like; 1.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..492
FT /note="Autophagy-related protein 17"
FT /id="PRO_0000317988"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55103 MW; 489BFB17409A7F64 CRC64;
MASPTNAPGS QSQTSVSSAN HPDPIIHGRE ILETLVSHLL ASKRSLSSIS TVWRANEIVT
SAKTALEESV ILNARTGFLQ SGINEQMKVL MKVRNSIECV YNDGQKDFKN VLHTLDAANA
RLESTMDVLR STMVDAAFRP AGEEPRSLLD FVDEQGVEGM RDGLKELIRE SKETQKEFDT
SLLSFDDDLR SLRSGFKNTK VSPPSYSPIP SHLATLEGHA QEMAALLSSL SSHFDLCLNA
IRHTEGGYAA VRNAASNPPP GAEPVSVSGV MNTSHDDINE EPLTEHEREE MLFVLEKDAA
EVEDVVMELR DRQNEMEIKH DAILDHVSHL TEQFKQTTSI YKILEGVYER LPGYIIAGQD
FRARWEDTKA QICGQMDDLE GMRLFYENYL SSYDGLILEV RRRKVAEEKA KTIAKKAMEQ
ISKIYDADMK ERHDFKHDVG DYLPVDLYPG INAAAPRWEF RLMEDEEAVN SSPSLERELV
EVSSKRDGEA QG
//
