ID AVT1A_ARATH Reviewed; 536 AA.
AC O80668; Q8H139; Q94BP2;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 24-JAN-2024, entry version 145.
DE RecName: Full=Amino acid transporter AVT1A {ECO:0000305};
DE Short=AtAvt1A {ECO:0000303|PubMed:27925655};
GN Name=AVT1A {ECO:0000303|PubMed:27925655};
GN OrderedLocusNames=At2g41190 {ECO:0000312|Araport:AT2G41190};
GN ORFNames=T3K9.4 {ECO:0000312|EMBL:AEC09942.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27925655; DOI=10.1002/1873-3468.12507;
RA Fujiki Y., Teshima H., Kashiwao S., Kawano-Kawada M., Ohsumi Y.,
RA Kakinuma Y., Sekito T.;
RT "Functional identification of AtAVT3, a family of vacuolar amino acid
RT transporters, in Arabidopsis.";
RL FEBS Lett. 591:5-15(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.
CC {ECO:0000305}.
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DR EMBL; AC004261; AAD11993.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC09942.1; -; Genomic_DNA.
DR EMBL; AY039978; AAK64155.1; -; mRNA.
DR EMBL; AY079364; AAL85095.1; -; mRNA.
DR EMBL; BT000792; AAN31931.1; -; mRNA.
DR PIR; T02100; T02100.
DR RefSeq; NP_030664.1; NM_129684.3.
DR AlphaFoldDB; O80668; -.
DR SMR; O80668; -.
DR IntAct; O80668; 1.
DR STRING; 3702.O80668; -.
DR iPTMnet; O80668; -.
DR PaxDb; 3702-AT2G41190-1; -.
DR ProteomicsDB; 240935; -.
DR EnsemblPlants; AT2G41190.1; AT2G41190.1; AT2G41190.
DR GeneID; 818718; -.
DR Gramene; AT2G41190.1; AT2G41190.1; AT2G41190.
DR KEGG; ath:AT2G41190; -.
DR Araport; AT2G41190; -.
DR TAIR; AT2G41190; -.
DR eggNOG; KOG1303; Eukaryota.
DR HOGENOM; CLU_009646_1_0_1; -.
DR InParanoid; O80668; -.
DR OMA; FHCMMEW; -.
DR OrthoDB; 3425278at2759; -.
DR PhylomeDB; O80668; -.
DR PRO; PR:O80668; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80668; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR48017:SF111; AMINO ACID TRANSPORTER AVT1A; 1.
DR PANTHER; PTHR48017; OS05G0424000 PROTEIN-RELATED; 1.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..536
FT /note="Amino acid transporter AVT1A"
FT /id="PRO_0000440102"
FT TRANSMEM 146..166
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..425
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 445..465
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..488
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 58863 MW; 48C1393F984A5337 CRC64;
MEDKNNDKEK KTDVTFEDDE DNEDLEDNSS KYENDSETDQ SDLGDLPGDA VDRDDDIDEP
FISQVQWPQS FRETTDSYTI AASPIFGSLR SNPPSFYRAS RSNLDVESKA PLLPERHDDS
DKASATQSAW SHKGSFAEEL PIGGYGCSVI QTIFNAINVM AGVGLLSTPY TVKEAGWASM
VILLLFAVIC CYTATLMKDC FENKTGIITY PDIGEAAFGK YGRILICMLL YTELYSYCVE
FIILEGDNLT GLFPGTSLDL LGFRLDSKHL FGILTALIVL PTVWLKDLRI ISYLSAGGVI
ATALIAVSVF FLGTTGGIGF HHTGQAVKWN GIPFAIGIYG FCYSGHSVFP NIYQSMADKT
KFNKAVITCF IICVLLYGGV AIMGYLMFGE ATLSQITLNM PQDQFFSKVA QWTTVVSPFT
KYALLMNPLA RSIEELLPER MSENIWCFLL LRTALVASSV CSAFLIPFFG LMMALIGSLL
SILVAIIMPA LCFIKIMGNK ATRTQMILSS IIVAIGVVSG TLGTYSSVAK IIRNYQ
//
