ID B0C3I2_ACAM1 Unreviewed; 639 AA.
AC B0C3I2;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:ABW29816.1};
GN Name=shc {ECO:0000313|EMBL:ABW29816.1};
GN OrderedLocusNames=AM1_4845 {ECO:0000313|EMBL:ABW29816.1};
OS Acaryochloris marina (strain MBIC 11017).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Acaryochloridales;
OC Acaryochloridaceae; Acaryochloris.
OX NCBI_TaxID=329726 {ECO:0000313|EMBL:ABW29816.1, ECO:0000313|Proteomes:UP000000268};
RN [1] {ECO:0000313|EMBL:ABW29816.1, ECO:0000313|Proteomes:UP000000268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBIC 11017 {ECO:0000313|Proteomes:UP000000268};
RX PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y.,
RA Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M.,
RA Blankenship R.E., Touchman J.W.;
RT "Niche adaptation and genome expansion in the chlorophyll d-producing
RT cyanobacterium Acaryochloris marina.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
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DR EMBL; CP000828; ABW29816.1; -; Genomic_DNA.
DR RefSeq; WP_012165095.1; NC_009925.1.
DR AlphaFoldDB; B0C3I2; -.
DR STRING; 329726.AM1_4845; -.
DR KEGG; amr:AM1_4845; -.
DR eggNOG; COG1657; Bacteria.
DR HOGENOM; CLU_019345_0_0_3; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000000268; Chromosome.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000268};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..302
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 311..632
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 639 AA; 71643 MW; 1C7EB3F968749601 CRC64;
MAVRDRVNPK TLEAAIAASQ SYLLTQQDET GYWWAELESN VSITSEVVLL HKIWGTDRSR
PLEKVETYLR SQQRDHGGWE LYFDDGGEIS VSVEAYMALK LLGVPMEDPA MVRARQFILE
HGGISRTRVF TKLHLALIGC YEWRGIPSLP PWVMLLPEQF PFTIYEMSSW ARGSTVPLLI
VMDREPVYAV EAGFNLDELY VEGRHRAQFD LPLSNEWTDA FIYLDGLFKF AESTNLVPFR
EEGIRAAERW ILERQEATGD WGGIIPAMLN SLLGLKALDY DVHDPIIERG MAALDAFALE
TEDQYWIQPC ISPVWDTALV VRGLAESGLA PDHPALVKAG EWLLNKQILD YGDWSVKNPG
GLPGGWAFEF DNRFYPDVDD TAVVVMALNE VQLPDEQAKD AAIARAVNWI ATMQCRPGGW
AAFDINNDQD WLNALPYGDL KAMIDPNTAD VTARVLEMIG RCHQTTGKNS VDRALRYLRT
EQEPEGCWFG RWGVNYIYGT SGVLAALALI DPQGWQSQIQ QAAAWLVSCQ NTDGGWGETC
ASYDNPKLKG QGPSTASQTA WAIMGLLSAG EATSVYAEAA IERGVNYLTT TQKMDGTWDE
DYFTGTGFPG HFYLKYHLYQ QHFPLTALGR YQAMLQQKS
//
