ID B0CYZ0_LACBS Unreviewed; 628 AA.
AC B0CYZ0;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=CDC42 rho GTPase-activating protein {ECO:0000313|EMBL:EDR12533.1};
GN ORFNames=LACBIDRAFT_312053 {ECO:0000313|EMBL:EDR12533.1};
OS Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS (Laccaria laccata var. bicolor).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hydnangiaceae; Laccaria.
OX NCBI_TaxID=486041 {ECO:0000313|Proteomes:UP000001194};
RN [1] {ECO:0000313|EMBL:EDR12533.1, ECO:0000313|Proteomes:UP000001194}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 / ATCC MYA-4686 {ECO:0000313|Proteomes:UP000001194};
RX PubMed=18322534; DOI=10.1038/nature06556;
RA Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA Tuskan G., Grigoriev I.V.;
RT "The genome of Laccaria bicolor provides insights into mycorrhizal
RT symbiosis.";
RL Nature 452:88-92(2008).
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DR EMBL; DS547094; EDR12533.1; -; Genomic_DNA.
DR RefSeq; XP_001876797.1; XM_001876762.1.
DR AlphaFoldDB; B0CYZ0; -.
DR GeneID; 6072733; -.
DR KEGG; lbc:LACBIDRAFT_312053; -.
DR HOGENOM; CLU_011969_1_0_1; -.
DR InParanoid; B0CYZ0; -.
DR OrthoDB; 3030820at2759; -.
DR Proteomes; UP000001194; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001194};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..216
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 232..449
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 16..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 69360 MW; 73811F2A3D42E92E CRC64;
MAPNLSLKQR LTALSLAASS PTSPNMPDSP RSPTFRRKPF NFNPPWVKRA QESTSNGGYG
ESEMVQEVLS KMIFQAGVDF ETRPMVVLNA SVLPDPQAVS YDLLLSRILS YLNLYVEADY
TVIFFAAGGR HTPGWNWVWK AYRSLSRKYR KNLKQLYIVH SSFFSKMLFS LAGAIISPKF
FRKLSYIATL SELAQRVPLT QIDIPPTVYQ ENLKYERKIT LPVPNRSSIF GVPLEELMGF
YGEKNGIPRV VRDSILFLRE RGLAEEGLFR RSPSSVMLRA AQDAYDRGNV VSLENFGDPH
LAAVLLKKYL RDLPEPVFPE RLYPLIRRCP SPTNDPSDMT SVTYIREVLF PELPPCVYIL
LSHVLHLMHD VSVRSASNRM DEHNLVVVIC PNLVKGANPA RDVMMCAVSG LPSLFESKST
GMNSDPISEG RTTLGMVIVL CIRRYYEVFD ETPDRTEAIL PQRRIPDENE ASSSRSSGSA
SPSHIFHDED DDIDDAMLVM PLGPSHSSNG SVQHTHSPPS AWTSSNGVSG TSTPRSMHTI
RGENGHSGLN ASYQFPTNGK AKSMISIEKA GTVGGGRKGS ISVGRGTTRK SSGAGVEALG
VTAEGFFSAP SDAPPLPSRD RRWNGDVS
//
