ID B0D350_LACBS Unreviewed; 833 AA.
AC B0D350;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 08-NOV-2023, entry version 48.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=LACBIDRAFT_189552 {ECO:0000313|EMBL:EDR11216.1};
OS Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS (Laccaria laccata var. bicolor).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hydnangiaceae; Laccaria.
OX NCBI_TaxID=486041 {ECO:0000313|Proteomes:UP000001194};
RN [1] {ECO:0000313|EMBL:EDR11216.1, ECO:0000313|Proteomes:UP000001194}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 / ATCC MYA-4686 {ECO:0000313|Proteomes:UP000001194};
RX PubMed=18322534; DOI=10.1038/nature06556;
RA Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA Tuskan G., Grigoriev I.V.;
RT "The genome of Laccaria bicolor provides insights into mycorrhizal
RT symbiosis.";
RL Nature 452:88-92(2008).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; DS547096; EDR11216.1; -; Genomic_DNA.
DR RefSeq; XP_001878517.1; XM_001878482.1.
DR AlphaFoldDB; B0D350; -.
DR STRING; 486041.B0D350; -.
DR GeneID; 6073755; -.
DR KEGG; lbc:LACBIDRAFT_189552; -.
DR HOGENOM; CLU_005230_0_2_1; -.
DR InParanoid; B0D350; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000001194; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000001194};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 415..444
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 543..560
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 581..600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 641..661
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 105..132
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 833 AA; 94375 MW; 9576D7E447E3593A CRC64;
MTDEYPSLFR SERMSLVQLF VPTEVAHDTV AELGELGNVQ FNDLNPSVNP FQRSFVGEIR
RIDEMARRVR FFATQIEKEK DVIPIRPLYD SAPLITVGPR AAHTIDELDT TLAEHETRLT
KMNDSYQILS DRTKELIEAR HVLRETAVFF EKAQGRRSDI RSSFDDSSAP LLHHEDRESQ
FSPAEVQFDL EFVAGTIERS RVPTFERVLW RVLRGNLYMN HTDIVEPFID PTTLVETRKN
VFIIFAHGDA LLAKIRKVAE SMGATIYPID PNANKRSESL REVTIRLEDL ETALYRTGLT
RRSELVLVGE SLRSWQDVVR KEKMIYEALN LFNYDVRRKT LIAEAWVPTR DIVTIQLALR
HATEESGTSV PPILQELQTF KTPPTFHKTN KFTEGFQTIM DSYGIARYQE VNPGLFAVAT
FPFLFAVMFG DIGHGAIIFC AALYMILSER RLAKADLDEI TGQFFFGRYI ILLMGLFSMY
TGFMYNDIFS KSLHIWHSGW TFPEGSGTIT GAFNGHTYPF GLDPGWHGAD NALVFTNSYK
MKMSIVLGVI HMTFALCLQV PNHFKFKRTV DIYTNFIPQM VFLQSIFGYL VLCILYKWSI
DWSKSAAGPP SLLNMLISMF LEPGTIAPGN RLYRGQGTVQ VVLLLMAAVC VPWLLIAKPY
LLWKETHKVH GQGYVGIGHD EPVRHSTDDA LEGEEEGNGR AIAEAAGEGH EQHDFSEVVI
HQIIHTIEFC LGCISHTASY LRLWALSLAH AQLSEVLWSM TIEGFLGPTT LFNWAALLFM
GTFWFGATVG ILCIMEGLSA FLHALRLHWV EANSKHFEGG GYAFAPLSFA SRE
//
