ID B0DLK7_LACBS Unreviewed; 535 AA.
AC B0DLK7;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EDR04585.1};
GN ORFNames=LACBIDRAFT_330527 {ECO:0000313|EMBL:EDR04585.1};
OS Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS (Laccaria laccata var. bicolor).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hydnangiaceae; Laccaria.
OX NCBI_TaxID=486041 {ECO:0000313|Proteomes:UP000001194};
RN [1] {ECO:0000313|EMBL:EDR04585.1, ECO:0000313|Proteomes:UP000001194}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 / ATCC MYA-4686 {ECO:0000313|Proteomes:UP000001194};
RX PubMed=18322534; DOI=10.1038/nature06556;
RA Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA Tuskan G., Grigoriev I.V.;
RT "The genome of Laccaria bicolor provides insights into mycorrhizal
RT symbiosis.";
RL Nature 452:88-92(2008).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; DS547117; EDR04585.1; -; Genomic_DNA.
DR RefSeq; XP_001884757.1; XM_001884722.1.
DR AlphaFoldDB; B0DLK7; -.
DR STRING; 486041.B0DLK7; -.
DR GeneID; 6080389; -.
DR KEGG; lbc:LACBIDRAFT_330527; -.
DR HOGENOM; CLU_045580_1_0_1; -.
DR InParanoid; B0DLK7; -.
DR OrthoDB; 1649721at2759; -.
DR Proteomes; UP000001194; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF447; HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06450)-RELATED; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001194};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..377
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 535 AA; 59223 MW; 04522ED3E4A938C2 CRC64;
MGQVQAWAAI LLPLLLGFYI YINDIRLKTL PSSIASLSKR CTPQNVRSMS ARLATEKPIS
IKDQLPPKTG RRYIIVGGGG FLGSWIVQQL LERGEDHKRV RLLDLSPPHN YAIKEALSRG
VQFIKIDVAN PVSLGAGFNA PWDDGHLLRD GETEPEITVF HTAANIRFYE RHAMFLDRSI
RVNVAGTQNV IDAARSVGAT ALIYTSSGSV GLRDTRLLLW PWESEPTHFV QPIVEDDERC
IPKRHEDFFS NYAASKWEAE KLVRGADKLP TGTAENGRVL KTGCIRPGNG IFGPGGDFMC
GYYLSRGGVP TWNPNVMQSF SYVENCACAH LCYEQRLIEL QSPGSQRQRN PDIGGQSFYI
SDPGPIPTYG DVYTALSTLC DGECRFTSIS PTGMLMFAHL IEGYYIIRHT LITSTWSLTR
LIAQKLLPPV QGDLLTFQPS LFTLTSVHML FDDSRARLSP EKGGLGYQGA WTTLEGIYKT
CVEHKSSMGR SNASPHTVGF MKAKTMEVVN GSQLKVVKGE TTVEIGPMEV MTVKQ
//
