ID B0FLN7_CHICK Unreviewed; 193 AA.
AC B0FLN7;
DT 26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Interferon {ECO:0000313|EMBL:ABY55306.1, ECO:0000313|Ensembl:ENSGALP00010017249.1};
GN Name=IFNA {ECO:0000313|EMBL:ABY55306.1};
GN Synonyms=IFN-gamma {ECO:0000313|EMBL:ACR83551.1}, IFNA3
GN {ECO:0000313|Ensembl:ENSGALP00010017249.1}, LOC100857947
GN {ECO:0000313|Ensembl:ENSGALP00010017279.1}, LOC100858506
GN {ECO:0000313|Ensembl:ENSGALP00010017302.1}, LOC100859414
GN {ECO:0000313|Ensembl:ENSGALP00010017259.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ABY55306.1};
RN [1] {ECO:0000313|EMBL:ABY55306.1}
RP NUCLEOTIDE SEQUENCE.
RA Guan W.J., Liu S., Liu C.Q., Ma Y.H.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR83551.1}
RP NUCLEOTIDE SEQUENCE.
RA Guan W.J., Ma Y.H., Bao A.D., Liu C.Q., Yu L.L.;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSGALP00010017249.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010017249.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has antiviral activities. {ECO:0000256|ARBA:ARBA00002718}.
CC -!- SIMILARITY: Belongs to the alpha/beta interferon family.
CC {ECO:0000256|ARBA:ARBA00011033, ECO:0000256|RuleBase:RU000436}.
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DR EMBL; EU334503; ABY55306.1; -; mRNA.
DR EMBL; FJ977575; ACR83551.1; -; mRNA.
DR RefSeq; XP_004937149.1; XM_004937092.2.
DR RefSeq; XP_004937151.1; XM_004937094.2.
DR STRING; 9031.ENSGALP00000060246; -.
DR PaxDb; 9031-ENSGALP00000042147; -.
DR Ensembl; ENSGALT00010029645.1; ENSGALP00010017249.1; ENSGALG00010012381.1.
DR Ensembl; ENSGALT00010029665.1; ENSGALP00010017259.1; ENSGALG00010012388.1.
DR Ensembl; ENSGALT00010029695.1; ENSGALP00010017279.1; ENSGALG00010012397.1.
DR Ensembl; ENSGALT00010029706.1; ENSGALP00010017287.1; ENSGALG00010012403.1.
DR Ensembl; ENSGALT00010029726.1; ENSGALP00010017302.1; ENSGALG00010012411.1.
DR GeneID; 100857403; -.
DR KEGG; gga:100857403; -.
DR KEGG; gga:100858506; -.
DR VEuPathDB; HostDB:LOC100857947; -.
DR VEuPathDB; HostDB:LOC100858506; -.
DR VEuPathDB; HostDB:LOC100859414; -.
DR VEuPathDB; HostDB:LOC121108631; -.
DR VEuPathDB; HostDB:LOC121108632; -.
DR eggNOG; ENOG502SQGR; Eukaryota.
DR GeneTree; ENSGT01000000214430; -.
DR HOGENOM; CLU_109427_1_0_1; -.
DR OMA; RNDSPHI; -.
DR OrthoDB; 5026254at2759; -.
DR Reactome; R-GGA-909733; Interferon alpha/beta signaling.
DR Reactome; R-GGA-912694; Regulation of IFNA/IFNB signaling.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000044725; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR GO; GO:0140374; P:antiviral innate immune response; IDA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0034141; P:positive regulation of toll-like receptor 3 signaling pathway; IEP:AgBase.
DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR CDD; cd00095; IFab; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000471; Interferon_alpha/beta/delta.
DR PANTHER; PTHR11691:SF37; INTERFERON OMEGA-1; 1.
DR PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR Pfam; PF00143; Interferon; 1.
DR PRINTS; PR00266; INTERFERONAB.
DR SMART; SM00076; IFabd; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00252; INTERFERON_A_B_D; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|RuleBase:RU000436}; Cytokine {ECO:0000256|RuleBase:RU000436};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..193
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014298104"
SQ SEQUENCE 193 AA; 22089 MW; F6BCDFC4247E89BE CRC64;
MAVPASPQHP RGYGILLLTL LLKALATTAS ACNHLRPQDA TFSHDSLQLL RDMAPTLPQL
CPQHNASCSF NDTILDTSNT RQADKTTHDI LQHLFTILSS PSTPAHWNDS QRQSLLNRIH
RYTQHLEQCL DSSDTRSRTR WPRNLHLTIK KHFSCLHTFL QDNDYSACAW EHVRLQARAW
FLHIHNLTGN TRT
//
