ID B0JHR8_MICAN Unreviewed; 1586 AA.
AC B0JHR8;
DT 18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT 18-MAR-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:BAG05480.1};
GN OrderedLocusNames=MAE_56580 {ECO:0000313|EMBL:BAG05480.1};
OS Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=449447 {ECO:0000313|EMBL:BAG05480.1, ECO:0000313|Proteomes:UP000001510};
RN [1] {ECO:0000313|EMBL:BAG05480.1, ECO:0000313|Proteomes:UP000001510}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-843 {ECO:0000313|EMBL:BAG05480.1,
RC ECO:0000313|Proteomes:UP000001510};
RX PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT Microcystis aeruginosa NIES-843.";
RL DNA Res. 14:247-256(2007).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; AP009552; BAG05480.1; -; Genomic_DNA.
DR RefSeq; WP_012267923.1; NC_010296.1.
DR STRING; 449447.MAE_56580; -.
DR PaxDb; 449447-MAE_56580; -.
DR EnsemblBacteria; BAG05480; BAG05480; MAE_56580.
DR KEGG; mar:MAE_56580; -.
DR PATRIC; fig|449447.4.peg.5169; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_2_2_3; -.
DR BioCyc; MAER449447:MAE_RS24650-MONOMER; -.
DR Proteomes; UP000001510; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 1.10.10.1830; Non-ribosomal peptide synthase, adenylation domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR041464; TubC_N.
DR InterPro; IPR044894; TubC_N_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF18563; TubC_N; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1033..1107
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1586 AA; 179207 MW; C0EB87B1162BE6E0 CRC64;
MKVAEFLSYL NSLDINLWLE EDKLKYQAPQ GAMTPEIKQE IGTRKPEILT FLRSATTPSK
PLESVIDPVA RTEELPLSFA QQRMWFLYQM DQQNSAYNEA LTIRLTGRLN IDILEQTINA
IIQRHESLRT TFPMVEGKPI QKIAPSLKIK LLVINLKDIP QEQIDKQIIE ELQKPFDLTQ
APLLRCTLFD LGYENYILVN VFHHIIIDGW SKGILFKELS KFYQALLSNS TVDLPELPIQ
YADFAVWQRQ WLQGEILENQ LNYWKKQLTG APPLLELPTD KPRPATANFR GHSISFQINS
ELTEKLKLLS QKSGATLFMT LLAALNTLLF RYSGQDDILI GTPTANRNRQ EIEPLIGFFV
NTLVLRNSLE GNPTFSGLLQ QARNVVLEAY ANQDVPFEQV VDGLEIERSL SYNPLFQVMF
ALQNAPLNAL ELPDLKAQYL AVENQRIKFD LSLVLEEIET EKGAYLEGFW EYDSDLFTAE
RITRMVGHFQ TLLKGIVANP QQTVGELPLL TESEEQQLLV EWNQTQTSYP DHYCIHQLFE
AWVEQTPDAI ALIFKGEQLT YRELNSKANQ LANYLQTLGV KPETLVGICI EPSLEMIVGI
LGILKAAGAY VPIDPTYPSE RIAYMLDDSQ LAVLLTEEKL VTSLPQHQAQ VICLDSDWKE
ISTESKSYPI TSLTPENLAY VIYTSGSTGK PKGVLVAHRG LCNLSQAQIK LFNVQPDSCV
LQFASISFDA SISEIVMALC AGARLYLGTR EELQPGQPLL ELLQEQEITH LTLVPSALAA
LSSENLPALQ NIIVAGEPCP PSLVIQWANG RRFFNAYGPT ESTVCATVAQ CFEDMNMLPI
GRPIANTKIY ILDRYLQPVP IGVPGELHLA SVGLAKGYLN RPELTDSKFI ANPFSQKLSD
RLYKTGDLVR YVNDGQIEFI GRIDHQVKIR GFRIELGEIE TILNQHPQVK EAIIIAREDQ
PGVKRLCAYV IASQNLTVSQ LRLFLQEKLP QYMVPAFFVL LDAFPLTPNG KIDRRALPQP
ALELENEAAI NFSPGTETER ILAAIWQRVL GLKTISINDN FFELGGDSIL AIQIIAQANQ
AGLQITPKQL FSHQTIAQLA TVAERVSVNQ TTQDLVIGHV PLTPIQKWFF EQNWPERHHF
NQSILLEVPN NLQPDLLKQT ISKLLYHHDA LRLRFVQKGE KWQQNHSDDC NNFAFEKVDL
SHLSCDEQLT KIAEISEVQQ RVLDLEEGPL MAVVFFALAE SGKMLIVIHH LAVDGISWRI
ILEDFVTIYQ QLENQKPLQL PPKTSSFKTW AEELQNYATT PEFHAQFKYW LNRDFPSISP
LPLDCQGEAQ SNIVAHAKTV SFTLTEEQTR LLLQEVPQAY NTQINDILLT ALVQAFGHWT
GSYKLLLDME GHGRENVIES VNLSRTVGWF TSIFPVFLTL ENLHHPGECL KSIKEQLRQI
PNRGFDYGIG YYLSSDLTIQ SPLKNYPKAQ VSFNYLGQFT SHQIGEIGWK LSQESTGSIH
SPLGQRSHLI AIHGIVVDGQ LDMEWQYSEN FHHQTTIKNL AAAYRDSLES LINHCLSAEG
GYTPSDFPDA DLNQVELDEL LSELDF
//
