ID B0JMB0_MICAN Unreviewed; 431 AA.
AC B0JMB0;
DT 18-MAR-2008, integrated into UniProtKB/TrEMBL.
DT 18-MAR-2008, sequence version 1.
DT 08-NOV-2023, entry version 90.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN OrderedLocusNames=MAE_33730 {ECO:0000313|EMBL:BAG03195.1};
OS Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Microcystaceae; Microcystis.
OX NCBI_TaxID=449447 {ECO:0000313|EMBL:BAG03195.1, ECO:0000313|Proteomes:UP000001510};
RN [1] {ECO:0000313|EMBL:BAG03195.1, ECO:0000313|Proteomes:UP000001510}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-843 {ECO:0000313|EMBL:BAG03195.1,
RC ECO:0000313|Proteomes:UP000001510};
RX PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT Microcystis aeruginosa NIES-843.";
RL DNA Res. 14:247-256(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; AP009552; BAG03195.1; -; Genomic_DNA.
DR RefSeq; WP_012266274.1; NC_010296.1.
DR AlphaFoldDB; B0JMB0; -.
DR STRING; 449447.MAE_33730; -.
DR REBASE; 17096; M.Mae843ORF33730P.
DR PaxDb; 449447-MAE_33730; -.
DR EnsemblBacteria; BAG03195; BAG03195; MAE_33730.
DR KEGG; mar:MAE_33730; -.
DR PATRIC; fig|449447.4.peg.3054; -.
DR eggNOG; COG0270; Bacteria.
DR HOGENOM; CLU_006958_2_1_3; -.
DR OMA; YSKAKFM; -.
DR BioCyc; MAER449447:MAE_RS14560-MONOMER; -.
DR Proteomes; UP000001510; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 431 AA; 49237 MW; E0F2B2455D7A56C7 CRC64;
MNRQQKRVLS LFSGCGGMDL GLEGGFWVHQ DCVNENIHRD WIVERREPWL KLPRTTFETV
FANDITKAAH NAWIPYFEKR GKKNVFHLGS IVDLVKQAEK GEFQFPSNID VVTGGFPCQD
FSVSGKRKGF NSHKSHTGKL LDESEDSFQD NRGKLYYWMK RVIELTLPKV FIAENVKGLI
SLANVKDIIE DDFSAIGKDG YIVIPKLLFA PDYGIPQTRE RIIFIGLNKT YLKATAIGHL
ENHDIFPRPT HKVIKHQLNL FESIYPLKTY STVGQILSGL AEPEDELFDL SQKSYSKAKH
YGKTQGQIEV NLQGLSPTIR SEHHGNIEFR RLSLELGGKI VNELEAGLKM RRLTVRECAR
IQTFPDDFQF VRPQNKGDEK YSLSATDGYK LIGNAVPPLL AYHIARHLEH QWDYLFEDIY
SVSKNLCVAL P
//