ID ZIP4L_ARATH Reviewed; 936 AA.
AC B0M1H3; A5Y6I6;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=TPR repeat-containing protein ZIP4 {ECO:0000305};
DE AltName: Full=Protein SPO22 homolog {ECO:0000305};
DE Short=AtSPO22 {ECO:0000303|PubMed:17530928};
DE AltName: Full=Protein ZIP4 homolog {ECO:0000305};
DE Short=AtZIP4 {ECO:0000303|PubMed:18348867};
GN Name=ZIP4 {ECO:0000303|PubMed:17530928};
GN Synonyms=SPO22 {ECO:0000303|PubMed:17530928};
GN OrderedLocusNames=At5g48390 {ECO:0000312|Araport:AT5G48390};
GN ORFNames=MJE7.2 {ECO:0000312|EMBL:BAA96959.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=cv. Wassilewskija;
RX PubMed=17530928; DOI=10.1371/journal.pgen.0030083;
RA Chelysheva L., Gendrot G., Vezon D., Doutriaux M.P., Mercier R., Grelon M.;
RT "Zip4/Spo22 is required for class I CO formation but not for synapsis
RT completion in Arabidopsis thaliana.";
RL PLoS Genet. 3:E83-E83(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18348867; DOI=10.1016/j.bbrc.2008.03.036;
RA Kuromori T., Azumi Y., Hayakawa S., Kamiya A., Imura Y., Wada T.,
RA Shinozaki K.;
RT "Homologous chromosome pairing is completed in crossover defective atzip4
RT mutant.";
RL Biochem. Biophys. Res. Commun. 370:98-103(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Required for meiotic chromosome segregation. It is involved
CC in interference-sensitive crossovers (class I meiotic crossover)
CC formation, in both male and female meiosis. Is specific to
CC recombination events resulting in interference-sensitive crossovers
CC (class I meiotic crossover). Not required for synapsis completion.
CC {ECO:0000269|PubMed:17530928, ECO:0000269|PubMed:18348867}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17530928,
CC ECO:0000269|PubMed:18348867}. Chromosome {ECO:0000269|PubMed:17530928,
CC ECO:0000269|PubMed:18348867}. Note=Detected in punctuate foci onto the
CC chromosomes in prophase I meiocytes. {ECO:0000269|PubMed:17530928,
CC ECO:0000269|PubMed:18348867}.
CC -!- DISRUPTION PHENOTYPE: Short siliques and low fertility due to defect in
CC meiosis. {ECO:0000269|PubMed:17530928}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA96959.1; Type=Erroneous gene model prediction; Note=The predicted gene At5g48390 has been split into 2 genes: At5g48385 and At5g48390.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF176583; ABO71664.1; -; mRNA.
DR EMBL; AB354634; BAG07186.1; -; mRNA.
DR EMBL; AB020745; BAA96959.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95664.1; -; Genomic_DNA.
DR RefSeq; NP_199650.3; NM_124214.7.
DR AlphaFoldDB; B0M1H3; -.
DR STRING; 3702.B0M1H3; -.
DR PaxDb; 3702-AT5G48390-1; -.
DR EnsemblPlants; AT5G48390.1; AT5G48390.1; AT5G48390.
DR GeneID; 834894; -.
DR Gramene; AT5G48390.1; AT5G48390.1; AT5G48390.
DR KEGG; ath:AT5G48390; -.
DR Araport; AT5G48390; -.
DR TAIR; AT5G48390; ATSPO22.
DR eggNOG; KOG4814; Eukaryota.
DR HOGENOM; CLU_307264_0_0_1; -.
DR InParanoid; B0M1H3; -.
DR OMA; INEAHWF; -.
DR OrthoDB; 1221686at2759; -.
DR PhylomeDB; B0M1H3; -.
DR PRO; PR:B0M1H3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; B0M1H3; baseline and differential.
DR Genevisible; B0M1H3; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007143; P:female meiotic nuclear division; IMP:TAIR.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:EnsemblPlants.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:TAIR.
DR GO; GO:0090173; P:regulation of synaptonemal complex assembly; IEA:InterPro.
DR GO; GO:0071139; P:resolution of DNA recombination intermediates; IEA:EnsemblPlants.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IMP:TAIR.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR039057; Spo22/ZIP4.
DR InterPro; IPR013940; Spo22/ZIP4/TEX11.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR40375; SPORULATION-SPECIFIC PROTEIN 22; 1.
DR PANTHER; PTHR40375:SF2; SPORULATION-SPECIFIC PROTEIN 22; 1.
DR Pfam; PF08631; SPO22; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Chromosome; DNA recombination; Meiosis; Nucleus; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..936
FT /note="TPR repeat-containing protein ZIP4"
FT /id="PRO_0000432119"
FT REPEAT 134..167
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 223..260
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 278..311
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 443..476
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 484..517
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REPEAT 879..912
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT CONFLICT 647
FT /note="A -> V (in Ref. 1; ABO71664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 936 AA; 103743 MW; 6777B1587CEAD8D2 CRC64;
MRIAEITTPD LRLHHRETDS HTHHPLLSEI ELLIQQSEAI SKDQPLPQSL PISLRQFLTR
LSQLAPFPDN SFKLTIWKLS FRLWNACVDL ANAASLQSSL TSAENIANLR HVAADMLFLA
KDVTGVPSPT IKSSLFYYKT GLVYHSLKKF DLASDCFERA TEIVSKIDIA KISDAGEKKL
FLDLNLARSR TAWEISDRNL AVTLLNRAKN LLFGSPDHYK SLSNQFLAFG KSSLSRGDDD
CSLNDALRLM NEALDLCEKG LGTAKTREDT TEFTAMRIKT LRFISAVHLQ KGEFENVIKC
VKVLRNGGNG SDGADQHASL PVLAMKAWLG LGRHSEAEKE LRGMVGNNDI PEAVWVSAVE
AYFEVVGTAG AETAKGVFLG LLGRCHVSAK AALRVAHRVL GESRGGDNGS RIRANVVAQL
VSDERVVALF ASEAVTKERK AIHSVLWNSA SDHFRAKDYE TSAEMFEKSM LYIPHDIENR
VFRAKGFRVL CLCYLGLSQL DRALEYIEEA EKLEPNIACS FLKFKIYLQK KEHSCAIGQI
DAMTSCLDFS PDYLSLSAHE AISCQALPVA VASLSKFLSF YISGKKMPTT EVVVFRTLVT
ILTQDIGSET EALNFMLQAQ SRASKLGTEC FFGLGETGKR EQNWFAATCW NLGSRCGKEK
KYELCGEFLR LASEFYGYID TDESGEDKLM ICRSIILSVT AMIALEKQTK SALTETQVKL
AAELLVRAGK IMSSSLSDGK DCIMEPELIF MYTLLAYDIH GRLNNSAFQL LVVKTFAGSK
SCHYNYLLQL GIFASQSPQS NPDVSTFALN ECLSALIASA SPEYPTIALI IRKLISIASV
HKGDTDDEEA ILKMYKQAYR IMVGLKEGEY PTEEGKWLAM TAWNRAALPV RLGQFETAKK
WLSIGLEIAD KVTGMDTYKA CMQDYLAGFQ TKVSSA
//
