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Database: UniProt
Entry: B0QZN5_MOUSE
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Original site: B0QZN5_MOUSE 
ID   B0QZN5_MOUSE            Unreviewed;       163 AA.
AC   B0QZN5;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=Vesicle-associated membrane protein 2 {ECO:0000256|ARBA:ARBA00013912};
DE   AltName: Full=Synaptobrevin-2 {ECO:0000256|ARBA:ARBA00031647};
GN   Name=Vamp2 {ECO:0000313|Ensembl:ENSMUSP00000112611.2,
GN   ECO:0000313|MGI:MGI:1313277};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112611.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000112611.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112611.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000112611.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112611.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004143}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00004143}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00004211}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family.
CC       {ECO:0000256|ARBA:ARBA00008025}.
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DR   AlphaFoldDB; B0QZN5; -.
DR   SMR; B0QZN5; -.
DR   SwissPalm; B0QZN5; -.
DR   jPOST; B0QZN5; -.
DR   MaxQB; B0QZN5; -.
DR   PeptideAtlas; B0QZN5; -.
DR   ProteomicsDB; 322539; -.
DR   Ensembl; ENSMUST00000117780.2; ENSMUSP00000112611.2; ENSMUSG00000020894.17.
DR   AGR; MGI:1313277; -.
DR   MGI; MGI:1313277; Vamp2.
DR   VEuPathDB; HostDB:ENSMUSG00000020894; -.
DR   GeneTree; ENSGT00940000158370; -.
DR   PhylomeDB; B0QZN5; -.
DR   ChiTaRS; Vamp2; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000020894; Expressed in perirhinal cortex and 258 other cell types or tissues.
DR   ExpressionAtlas; B0QZN5; baseline and differential.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:Ensembl.
DR   GO; GO:0031201; C:SNARE complex; IEA:Ensembl.
DR   GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR   GO; GO:0043308; P:eosinophil degranulation; IEA:Ensembl.
DR   GO; GO:0006906; P:vesicle fusion; IEA:Ensembl.
DR   CDD; cd15870; R-SNARE_VAMP2; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   InterPro; IPR001388; Synaptobrevin-like.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45701; SYNAPTOBREVIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR45701:SF5; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   SUPFAM; SSF58038; SNARE fusion complex; 1.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   1: Evidence at protein level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:B0QZN5,
KW   ECO:0007829|MaxQB:B0QZN5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        93..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..91
FT                   /note="V-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50892"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   163 AA;  17862 MW;  E2A57B15CFF89EAF CRC64;
     MSATAATVPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL
     SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IGEWGQRPGP
     LPWGGRGFPW GAWALKVTNL VFTLQPKHTL LLLAVLTHLE PKT
//
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