ID B0R0C1_MOUSE Unreviewed; 1169 AA.
AC B0R0C1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Myelin transcription factor 1 {ECO:0000313|Ensembl:ENSMUSP00000079900.5};
GN Name=Myt1 {ECO:0000313|Ensembl:ENSMUSP00000079900.5,
GN ECO:0000313|MGI:MGI:1100535};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000079900.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000079900.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079900.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000079900.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079900.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR RefSeq; NP_001165086.1; NM_001171615.1.
DR AlphaFoldDB; B0R0C1; -.
DR SMR; B0R0C1; -.
DR MaxQB; B0R0C1; -.
DR PeptideAtlas; B0R0C1; -.
DR ProteomicsDB; 356924; -.
DR Antibodypedia; 1424; 323 antibodies from 26 providers.
DR DNASU; 17932; -.
DR Ensembl; ENSMUST00000081125.11; ENSMUSP00000079900.5; ENSMUSG00000010505.17.
DR GeneID; 17932; -.
DR UCSC; uc008onr.2; mouse.
DR AGR; MGI:1100535; -.
DR CTD; 4661; -.
DR MGI; MGI:1100535; Myt1.
DR VEuPathDB; HostDB:ENSMUSG00000010505; -.
DR GeneTree; ENSGT00940000156364; -.
DR OrthoDB; 3091993at2759; -.
DR PhylomeDB; B0R0C1; -.
DR TreeFam; TF317299; -.
DR BioGRID-ORCS; 17932; 3 hits in 81 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000010505; Expressed in floor plate of midbrain and 144 other cell types or tissues.
DR ExpressionAtlas; B0R0C1; baseline and differential.
DR Genevisible; B0R0C1; MM.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 7.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF10; MYELIN TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 2.
DR Pfam; PF01530; zf-C2HC; 7.
DR SUPFAM; SSF103637; CCHHC domain; 7.
DR PROSITE; PS51802; ZF_CCHHC; 7.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|MaxQB:B0R0C1,
KW ECO:0007829|ProteomicsDB:B0R0C1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 604..659
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT DOMAIN 661..834
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 47..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1041..1103
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..353
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1169 AA; 128673 MW; 7E7B85BA3693E1F4 CRC64;
MTLCGSFLEN EFRGKLLTQR WTQEDKTSSC RTERHFLCRY NKMSSESDDK RARTRSKTLR
GPPETTGADL SCPTPGCTGS GHVRGKYSRH RSLQSCPLAK KRKLEDAETE HLVSKRKSHP
LRLALDEGYR MDSDGSEDAE VKDVSVSDES EGPLEEAEAE MSGQEEIHHP QTAEGKSLIK
PHFDSNPTSS PSGFSKSSYS SYQGIIATSL LNLGQIAEEA LVKEDSVSVA KLSPTVVHQL
QDEAAMGVNS DEGEKDLFIQ PEDVEEVIEV TSERSQEPCP QSLKDMVSEE SSKQKGVLGH
EEEGEEEEED EEEEDEEEEE EGEEGEEEEE EEEEEEEEED EEEEEEEEEA APNVIFGEDT
SHTSVQKASP EFRGPELSSP KPEYSVIVEV RSDDDKDEDS RSQKSAVTDE SEMYDMMTRG
NLGLLEQAIA LKAEQVRAVC ESGCPPAEQG HLGPGEPGKM AKPLDVVRKS CYSKDPSRVE
KREIKCPTPG CDGTGHVTGL YPHHRSLSGC PHKDRIPPEI LAMHENVLKC PTPGCTGQGH
VNSNRNTHRS LSGCPIAAAE KLAKSHEKQQ LQTGDPPKNN SNSDRILRPM CFVKQLEVPP
YGSYRPNVAP ATPRANLAKE LEKFSKVTFD YASFDAQVFG KRMLAPKIQT SETSPKAFQC
FDYSHDAEAA HMAATAILNL STRCWEMPEN LSTKPQDLPS KAVDIEVDEN GTLDLSMHKH
RKRENTFPSS SSCSSSPGVK SPDVSQRQSS TSAPSSSMTS PQSSQASRQD EWDRPLDYTK
PSRLREEEPE ESEPAAHSFA SSEADDQEVS EENFEERKYP GEVTLTNFKL KFLSKDIKKE
LLTCPTPGCD GSGHITGNYA SHRSLSGCPL ADKSLRNLMA AHSADLKCPT PGCDGSGHIT
GNYASHRSLS GCPRAKKSGL KVAPTKDDKE DPELMKCPVP GCVGLGHISG KYASHRSASG
CPLAARRQKE GALNGSSFSW KSLKNEGPTC PTPGCDGSGH ANGSFLTHRS LSGCPRATFA
GKKGKLSGDE ILSPKFKTSD VLENDEEIKQ LNQEIRDLNE SNSEMEAAMV QLQSQISSME
KNLKNIEEEN KLIEEQNEAL FLELSGLSQA LIQSLANIRL PHMEPICEQN FDAYVNTLTD
MYSNQDCYQN PENKGLLETI KQAVRGIQV
//
