ID B0R0D5_MOUSE Unreviewed; 500 AA.
AC B0R0D5;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=FERM domain containing 5 {ECO:0000313|Ensembl:ENSMUSP00000120176.2};
DE Flags: Fragment;
GN Name=Frmd5 {ECO:0000313|Ensembl:ENSMUSP00000120176.2,
GN ECO:0000313|MGI:MGI:2442557};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000120176.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000120176.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120176.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000120176.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120176.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; B0R0D5; -.
DR SMR; B0R0D5; -.
DR MaxQB; B0R0D5; -.
DR ProteomicsDB; 316553; -.
DR Antibodypedia; 2633; 115 antibodies from 17 providers.
DR Ensembl; ENSMUST00000155570.8; ENSMUSP00000120176.2; ENSMUSG00000027238.18.
DR UCSC; uc008lzn.1; mouse.
DR AGR; MGI:2442557; -.
DR MGI; MGI:2442557; Frmd5.
DR VEuPathDB; HostDB:ENSMUSG00000027238; -.
DR GeneTree; ENSGT00940000156346; -.
DR ChiTaRS; Frmd5; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000027238; Expressed in cardiac muscle of left ventricle and 188 other cell types or tissues.
DR ExpressionAtlas; B0R0D5; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13192; FERM_C_FRMD3_FRMD5; 1.
DR CDD; cd17102; FERM_F1_FRMD3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF5; FERM DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:B0R0D5,
KW ECO:0007829|PeptideAtlas:B0R0D5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 6..290
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 336..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000120176.2"
SQ SEQUENCE 500 AA; 56384 MW; 19FBE91A981B5C51 CRC64;
KPRRGRASTF HGRFGGLKES HRQNAERDAK GQYLFDLLCH HLNLLEKDYF GIRFVDPDKQ
RHWLEFTKSV VKQLRSQPPF TMCFRVKFYP ADPAALKEEI TRYLVFLQIK RDLYHGRLLC
KTSDAALLAA YILQAEIGDY DPGKHPEGYS SKFQFFPKHS EKLEKKIAEI HKTELSGQTP
ATSELNFLRK AQTLETYGVD PHPCKDVSGN AAFLAFTPFG FVVLQGNKRV HFIKWNEVTK
LKFEGKTFYL YVSQKEEKKI ILTYFAPTPE ACKHLWKCGI ENQAFYKLEK SSQVRTVSSS
NLFFKGSRFR YSGRVAKEVM ESSAKIKREP PEIHRAGMVP SRSCPSITHG PRLSSVPRTR
RRAVHISIME GLESLRDSAH STPVRSSSHG DTFLPHVRSS RADSNERVAV IADEAYSPAD
SVLPTPVAEH SLELMLLSRQ INGATCSIEE EKESEASTPT ATEAEALGGE LRALCQGHGG
SEQEQAMVCL QNPLSGEPAH
//
