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Database: UniProt
Entry: B0S6D0_DANRE
LinkDB: B0S6D0_DANRE
Original site: B0S6D0_DANRE 
ID   B0S6D0_DANRE            Unreviewed;       920 AA.
AC   B0S6D0;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   08-MAY-2019, entry version 94.
DE   RecName: Full=Neuropilin {ECO:0000256|PIRNR:PIRNR036960};
GN   Name=nrp2b {ECO:0000313|EMBL:AAI63576.1,
GN   ECO:0000313|Ensembl:ENSDARP00000056102,
GN   ECO:0000313|ZFIN:ZDB-GENE-040611-3};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000056102, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|EMBL:AAI63576.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000056102, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056102,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000056102}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000056102};
RG   Ensembl;
RL   Submitted (AUG-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the neuropilin family.
CC       {ECO:0000256|PIRNR:PIRNR036960}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; BX510337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR847508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC163576; AAI63576.1; -; mRNA.
DR   EMBL; BC163589; AAI63589.1; -; mRNA.
DR   STRING; 7955.ENSDARP00000056102; -.
DR   Ensembl; ENSDART00000056103; ENSDARP00000056102; ENSDARG00000038446.
DR   ZFIN; ZDB-GENE-040611-3; nrp2b.
DR   eggNOG; ENOG410IHB5; Eukaryota.
DR   eggNOG; ENOG410ZPIE; LUCA.
DR   GeneTree; ENSGT00940000155270; -.
DR   OMA; GPALHIK; -.
DR   TreeFam; TF316506; -.
DR   Proteomes; UP000000437; Chromosome 9.
DR   Bgee; ENSDARG00000038446; Expressed in 58 organ(s), highest expression level in neuron.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IMP:ZFIN.
DR   GO; GO:0007413; P:axonal fasciculation; IMP:ZFIN.
DR   GO; GO:0001755; P:neural crest cell migration; IGI:ZFIN.
DR   GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IMP:ZFIN.
DR   GO; GO:0001570; P:vasculogenesis; IMP:ZFIN.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00057; FA58C; 2.
DR   CDD; cd06263; MAM; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000998; MAM_dom.
DR   InterPro; IPR014648; Neuropilin.
DR   InterPro; IPR022579; Neuropilin_C.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF11980; DUF3481; 1.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   Pfam; PF00629; MAM; 1.
DR   PIRSF; PIRSF036960; Neuropilin; 1.
DR   PRINTS; PR00020; MAMDOMAIN.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00231; FA58C; 2.
DR   SMART; SM00137; MAM; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01285; FA58C_1; 2.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 2.
DR   PROSITE; PS00740; MAM_1; 1.
DR   PROSITE; PS50060; MAM_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|PIRSR:PIRSR036960-
KW   1}; Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Developmental protein {ECO:0000256|PIRNR:PIRNR036960};
KW   Differentiation {ECO:0000256|PIRNR:PIRNR036960};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR036960-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00059, ECO:0000256|SAAS:SAAS01008102};
KW   Membrane {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR036960-1};
KW   Neurogenesis {ECO:0000256|PIRNR:PIRNR036960};
KW   Receptor {ECO:0000256|PIRNR:PIRNR036960};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    920       Neuropilin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015086994.
FT   TRANSMEM    854    879       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    140       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      146    264       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      274    424       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      431    589       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      628    788       MAM. {ECO:0000259|PROSITE:PS50060}.
FT   METAL       194    194       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   METAL       208    208       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   METAL       249    249       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   DISULFID     26     53       {ECO:0000256|PIRSR:PIRSR036960-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID     81    103       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    146    172       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    205    227       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    274    424       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    431    589       {ECO:0000256|PIRSR:PIRSR036960-2}.
SQ   SEQUENCE   920 AA;  102642 MW;  202385103FE8DB05 CRC64;
     MDLFAKLCGS LLVLCAALVY GQEEPCGGSF DASDAGYITT PGYPLEYPPH QNCRWVITAP
     EPSQRIVLNF NPHFELEKLD CRYDFIEIRD GNSDGADLLG RHCSNIAPPA IISSGPVLHI
     KFVSDYAHQG AGFSLRYEIY KTGSDCSRNF TSPSGVIESP GFPDKYPHNL ECSFIIVVPP
     HMDVTLTFLT FDLENDPLQG SEGECKYDWL EVWDGLPQVG PLIGRHCGTK IPSEIQSSTG
     ILSLSFHTDM AVAKDGFSAR YNMTLKEVND NFHCSNDLGM ESGKISDDQI SASSSFYDGR
     WSPRQARLNF DDNAWTPNED SNKEYIQVDL HFLKVLTGIA TQGAVSKETH KSYFVTTFKL
     EVSTNGEDWM IYRFGKNHKV FHANADPSEV VLNRIPQPVL ARFVRIRPQS WKNGIALRFE
     LYGCQITDAP CSEMQGMLSG LLPDSQISAS SMRDIHGATG AARLVASRSG WFPSPTQPVA
     GEEWLQVDLG VPKTVRGIIT QGARGVDGST SAENRAFVRK YKLAHSLNGK DLSYIIDPKT
     NLPKIFEGNT HYDTPEIRRF DEIVAQFIRV YPERWSPAGI GMRMEILACD LPESTTIPDT
     ATPTIPAQEE TSTAHRTPAP TTLSSLGGLC DFEQSMCGWT HDPMSDLKWS MYSSSSPSLD
     LTHGPDNFGN FLYVEASPMS EPQRARLLSP SVGPERRLVC LLFYYQLRGA GQESLRVLLR
     DDDQEETLLW TLKGDQGSMW REGRTILPQS PKEYQVVIEG FFERGSRGHI RIDNIHMSSS
     IDLEQCTQPF AAFPPEMTER RPEDLGNNRL FKGRDRIGQE YPFPAWTTPN PSRDPPVTRI
     SEKDNAWLYT LDPILVTIIV MSSLGVLLGA VCAGLLLYCT CSYNGLSSRS TTTLENYNFE
     LYDGIKHKVK INQQRCCSEA
//
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