ID   B0SUP1_CAUSK            Unreviewed;       455 AA.
AC   B0SUP1;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Histidine triad (HIT) protein {ECO:0000313|EMBL:ABZ69919.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Caul_0788 {ECO:0000313|EMBL:ABZ69919.1};
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=366602 {ECO:0000313|EMBL:ABZ69919.1};
RN   [1] {ECO:0000313|EMBL:ABZ69919.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31 {ECO:0000313|EMBL:ABZ69919.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000927; ABZ69919.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0SUP1; -.
DR   KEGG; cak:Caul_0788; -.
DR   eggNOG; COG0537; Bacteria.
DR   eggNOG; COG1073; Bacteria.
DR   HOGENOM; CLU_610715_0_0_5; -.
DR   OrthoDB; 5902829at2; -.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR46648:SF1; ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1; 1.
DR   PANTHER; PTHR46648; HIT FAMILY PROTEIN 1; 1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..455
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002755165"
FT   DOMAIN          322..428
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           413..417
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT                   ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        415
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ   SEQUENCE   455 AA;  48482 MW;  4690F26BEE75479C CRC64;
     MKRQIAAGLA ALMLLGLAAS GQTEPRFAPI PKAVVADPVR DAAHPADMAA FTLPTGGVRV
     NALMYIASGD QPHPTMLFLH GFPGNETNID LMQAVRRAGW NVLKINYRGS WGSPGKFSFA
     GARADGEAAV AFLFDPANIA KYHIDPKRIV VAGHSMGGFM AADAAAAEPR LAGTVLIDAW
     DIGKNAAQIT SPATRKAAAD KMRPDTRPLA GTSAELLVKE IETNAAKLDL EALSARIANR
     PLLMVGAEHA RAPTIRKLAA AARQAQATAL TETYMDTDHG FSDHRIALEA EVVRWLGQFD
     PASAKPGTPR IPLKAPYDEA NPFARILRGE IAVPKVYEDD QVLAFMDYAP AEPGHVLVIS
     KTSKARNLLE ISPQDLSRIM AVAARVGQAQ VDGLGVEGFT IVQNNGVGQS VPHLHIHVIP
     RVAGKPLMFV ENEKGDPKDI AAMADKIRSA MKAPQ
//