ID B0TB70_HELMI Unreviewed; 340 AA.
AC B0TB70;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=holB {ECO:0000313|EMBL:ABZ83797.1};
GN ORFNames=HM1_0758 {ECO:0000313|EMBL:ABZ83797.1};
OS Heliobacterium modesticaldum (strain ATCC 51547 / Ice1).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Heliobacteriaceae;
OC Heliomicrobium.
OX NCBI_TaxID=498761 {ECO:0000313|EMBL:ABZ83797.1, ECO:0000313|Proteomes:UP000008550};
RN [1] {ECO:0000313|EMBL:ABZ83797.1, ECO:0000313|Proteomes:UP000008550}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51547 / Ice1 {ECO:0000313|Proteomes:UP000008550};
RX PubMed=18441057; DOI=10.1128/JB.00299-08;
RA Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M.,
RA Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E.,
RA Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T.,
RA Raymond J., Chen M., Blankenship R.E., Touchman J.W.;
RT "The genome of Heliobacterium modesticaldum, a phototrophic representative
RT of the Firmicutes containing the simplest photosynthetic apparatus.";
RL J. Bacteriol. 190:4687-4696(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP000930; ABZ83797.1; -; Genomic_DNA.
DR AlphaFoldDB; B0TB70; -.
DR STRING; 498761.HM1_0758; -.
DR KEGG; hmo:HM1_0758; -.
DR eggNOG; COG0470; Bacteria.
DR HOGENOM; CLU_006229_4_5_9; -.
DR Proteomes; UP000008550; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004622; DNA_pol_HolB.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00678; holB; 1.
DR PANTHER; PTHR11669:SF8; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000008550};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 340 AA; 36933 MW; 52A8BDB986D296EE CRC64;
MAVRLLQITG QERAIRQLSR GLLANRVAHA YLFSGPQGVG KKTAARAFAQ SVLCLERAGG
DACASCPACR QFQGGSHPDL FSLSPEGTTL KIEQIRNLQK RIRYRPYLSS HQVVLIEQAE
TMQGPSANAL LKILEEPPGP TVFILITDRG HGILPTIRSR CLPVYFQPVP SGEIARFLKE
KGVSAGHVSL LTLLADGRWD RAARLAAEGL PAGRERARQV LDGLALTGDS RIFQLAEEWD
KDKEGIAEFF DYLTLLLRDR LLIAGAGGAE VPVINGDITG GADRWPLPVL LTALDTVMAA
RRLLDTNASA RLLVEDTLLK LRDLARGEPL TPLTAAKVNL
//
