ID B0UXQ0_HUMAN Unreviewed; 365 AA.
AC B0UXQ0; A0A0D6K955;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=HLA class I histocompatibility antigen, A alpha chain {ECO:0000313|Ensembl:ENSP00000408986.1};
DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CAQ16345.1, ECO:0000313|EMBL:CDO33932.1};
DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:QAX33599.1};
GN Name=HLA-A {ECO:0000313|EMBL:CAQ16345.1,
GN ECO:0000313|Ensembl:ENSP00000408986.1};
GN Synonyms=HLA {ECO:0000313|EMBL:ASU50344.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAQ16345.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000408986.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|EMBL:CAQ16345.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ16345.1};
RA Heinold A., Schaller-Suefling E., Opelz G., Scherer S., Tran T.H.;
RT "Identification of two novel HLA alleles, HLA-A*02010103 and HLA-B*4455,
RT and characterization of the complete genomic sequence of HLA-A*290201.";
RL Tissue Antigens 72:397-400(2008).
RN [3] {ECO:0000313|EMBL:CAQ16345.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CAQ16345.1};
RA Tran H.;
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5] {ECO:0000313|EMBL:ADQ48108.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21859426; DOI=10.1111/j.1399-0039.2011.01752.x;
RA Xu Y., Li Z., Zou H., Deng Z.;
RT "Two novel HLA-A alleles, A*29:02:01:02 and A*68:01:01:02, were identified
RT by genomic full-length cloning and sequencing.";
RL Tissue Antigens 79:72-74(2012).
RN [6] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7] {ECO:0000313|EMBL:CDO33932.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Peripheral blood {ECO:0000313|EMBL:CDO33932.1};
RA McWhinnie A.J., Robinson J.;
RT "Confirmatory sequencing of HLA-A*29:02:01:02.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:CEG62396.1}
RP NUCLEOTIDE SEQUENCE.
RA Voorter C.;
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:CEG62396.1}
RP NUCLEOTIDE SEQUENCE.
RA Gerritsen K.E.H., Olieslagers T.I., Groeneweg M., Voorter C.E.M.,
RA Tilanus M.G.J.;
RT "An improved and validated RNA HLA class I SBT approach for obtaining full
RT length coding sequences.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [11] {ECO:0000313|EMBL:CRX74685.1}
RP NUCLEOTIDE SEQUENCE.
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:CTQ48004.1}
RP NUCLEOTIDE SEQUENCE.
RA Tran T., Druce J.;
RT "MeaNS - Measles Nucleotide Surveillance Program.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:CUA55064.1}
RP NUCLEOTIDE SEQUENCE.
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:CRX74685.1}
RP NUCLEOTIDE SEQUENCE.
RA Rikkerink E.H.A., Fineran P.C.;
RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal
RT Agent of Kiwifruit Canker Disease.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:SBV08748.1}
RP NUCLEOTIDE SEQUENCE.
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:CUA55064.1}
RP NUCLEOTIDE SEQUENCE.
RA Marsh S.G.E.;
RT "Full-length genomic HLA sequences.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:CQR91464.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28547825; DOI=10.1111/tan.13057;
RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., Dahl A.,
RA Winkler S., Lange V., Bohme I., Schmidt A.H.;
RT "Dual redundant sequencing strategy: Full-length gene characterisation of
RT 1056 novel and confirmatory HLA alleles.";
RL HLA 90:79-87(2017).
RN [18] {ECO:0000313|EMBL:ASU50344.1}
RP NUCLEOTIDE SEQUENCE.
RA Balz V., Krause S., Enczmann J., Fischer J.;
RT "More than 130 novel variants of HLA class 1 genes detected in German Stem
RT Cell Donor Registry and Terasaki samples.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [19] {ECO:0000313|EMBL:SMB18742.1}
RP NUCLEOTIDE SEQUENCE.
RA Masson D., Colom S.;
RT "x.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [20] {ECO:0000313|EMBL:AWB14529.1}
RP NUCLEOTIDE SEQUENCE.
RA Yin Y., Takemura P., Bolon Y.-T., Springer B., Saito K., Reed E.F.,
RA Zhang Q.J.;
RT "Advances in HLA clinical relevant exon novelty detection from over 21,000
RT donor recruitment samples.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN [21] {ECO:0000313|EMBL:SNQ25991.1}
RP NUCLEOTIDE SEQUENCE.
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [22] {ECO:0000313|EMBL:ASU61678.1}
RP NUCLEOTIDE SEQUENCE.
RA Lazaro A.M., Hou L., Gerfen J., Enriquez E., Hurley C.K.;
RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN [23] {ECO:0000313|EMBL:SNQ25991.1}
RP NUCLEOTIDE SEQUENCE.
RA Groeneweg M., Matern B., Palusci F., Meertens C., Tilanus M.G.J.,
RA Voorter C.E.M.;
RT "Group specific, unambiguous full-length gene HLA Class I typing by Sanger
RT sequencing: a robust SSBT Strategy for typing and a golden reference for
RT next generation sequencing approaches.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN [24] {ECO:0000313|EMBL:AUD08728.1}
RP NUCLEOTIDE SEQUENCE.
RA Lazaro A.M., Hou L., Enriquez E., Persaud M., Hurley C.K.;
RT "Novel HLA Class I alleles.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [25] {ECO:0000313|EMBL:ASA47552.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29327506; DOI=.1111/tan.13210;
RA Hurley C.K., Hou L., Lazaro A., Gerfen J., Enriquez E., Galarza P.,
RA Rodriguez Cardozo M.B., Halagan M., Maiers M., Behm D., Ng J.;
RT "Next generation sequencing characterizes the extent of HLA diversity in an
RT Argentinian registry population.";
RL HLA 91:175-186(2018).
RN [26] {ECO:0000313|EMBL:AUQ33054.1}
RP NUCLEOTIDE SEQUENCE.
RA Marsh S.G.E.;
RT "Nomenclature for factors of the HLA system, update December 2017.";
RL Int. J. Immunogenet. 0:0-0(2018).
RN [27] {ECO:0000313|EMBL:QAX33599.1}
RP NUCLEOTIDE SEQUENCE.
RA Balz V., Krause S., Enczmann J.;
RT "New HLA class 1 alleles.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [28] {ECO:0000313|EMBL:AWX41293.1}
RP NUCLEOTIDE SEQUENCE.
RA Go L.Y., Mitchell J.A.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [29] {ECO:0000313|EMBL:SPQ44332.1}
RP NUCLEOTIDE SEQUENCE.
RA Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA Wayne K.J., Tettelin H., Glass J.I., Rusch D., Podicherti R., Tsui H.-C.T.,
RA Winkler M.E.;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [30] {ECO:0000313|EMBL:QCP66133.1}
RP NUCLEOTIDE SEQUENCE.
RA Hurley C.K.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [31] {ECO:0000313|EMBL:QIE06070.1}
RP NUCLEOTIDE SEQUENCE.
RA Planelles D., Balas A., Ocejo G.;
RT "Characterization of new HLA alleles.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [32] {ECO:0000313|EMBL:QGN03558.1}
RP NUCLEOTIDE SEQUENCE.
RA Texeraud E., Bertrand G.;
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [33] {ECO:0000313|EMBL:QIA58934.1}
RP NUCLEOTIDE SEQUENCE.
RA York S.L., Ivery K.J., Williams J.D.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [34] {ECO:0000313|EMBL:QMI58388.1}
RP NUCLEOTIDE SEQUENCE.
RA Cereb N., Yang S.Y.;
RT "HLA new alleles found by Histogenetics.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
RN [35] {ECO:0000313|EMBL:CAD7619392.1}
RP NUCLEOTIDE SEQUENCE.
RA Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.;
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
RN [36] {ECO:0000313|EMBL:QXU63159.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:QXU63159.1};
RA Fuerst D., Tsamadou C., Neuchel C.;
RT "HLA-A*29:02var, a novel HLA-A allele.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [37] {ECO:0000313|EMBL:QXH29492.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=111353988 {ECO:0000313|EMBL:QQP18455.1}, and 1333472
RC {ECO:0000313|EMBL:QXH29492.1};
RA Gomez-Massa E.;
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [38] {ECO:0007829|PDB:7TLT}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS), AND DISULFIDE BONDS.
RX PubMed=36302758; DOI=10.1038/s41467-022-34180-1;
RA Swaminathan S., Lineburg K.E., Panikkar A., Raju J., Murdolo L.D.,
RA Szeto C., Crooks P., Le Texier L., Rehan S., Dewar-Oldis M.J.,
RA Barnard P.J., Ambalathingal G.R., Neller M.A., Short K.R., Gras S.,
RA Khanna R., Smith C.;
RT "Ablation of CD8<sup>+</sup> T cell recognition of an immunodominant
RT epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3.";
RL Nat. Commun. 13:6387-6387(2022).
RN [39] {ECO:0000313|Ensembl:ENSP00000408986.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
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DR EMBL; CR382333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; HM595424; ADQ48108.1; -; Genomic_DNA.
DR EMBL; KY350869; ASA47552.1; -; Genomic_DNA.
DR EMBL; KY762290; ASG91926.1; -; Genomic_DNA.
DR EMBL; KY419453; ASU50344.1; -; Genomic_DNA.
DR EMBL; MF474228; ASU61678.1; -; Genomic_DNA.
DR EMBL; MG189581; AUD08728.1; -; Genomic_DNA.
DR EMBL; MG450945; AUQ33054.1; -; Genomic_DNA.
DR EMBL; MG701419; AUQ33099.1; -; Genomic_DNA.
DR EMBL; MG701422; AUQ33102.1; -; Genomic_DNA.
DR EMBL; MF069203; AWB14529.1; -; Genomic_DNA.
DR EMBL; MH173417; AWM62176.1; -; Genomic_DNA.
DR EMBL; MH173438; AWM62197.1; -; Genomic_DNA.
DR EMBL; MH173443; AWM62202.1; -; Genomic_DNA.
DR EMBL; MH173467; AWM62225.1; -; Genomic_DNA.
DR EMBL; MH156679; AWX41293.1; -; Genomic_DNA.
DR EMBL; MH544292; AXN55423.1; -; Genomic_DNA.
DR EMBL; MH973883; AZL48417.1; -; Genomic_DNA.
DR EMBL; MH973887; AZL48421.1; -; Genomic_DNA.
DR EMBL; MK300272; AZU89867.1; -; Genomic_DNA.
DR EMBL; LR978689; CAD7619392.1; -; Genomic_DNA.
DR EMBL; LR978727; CAD7619430.1; -; Genomic_DNA.
DR EMBL; AM944568; CAQ16345.1; -; Genomic_DNA.
DR EMBL; HG965144; CDO33932.1; -; Genomic_DNA.
DR EMBL; LN623521; CEG62396.1; -; mRNA.
DR EMBL; LN832586; CQR91464.2; -; Genomic_DNA.
DR EMBL; LN868254; CRX74685.1; -; Genomic_DNA.
DR EMBL; LN873234; CTQ48004.1; -; Genomic_DNA.
DR EMBL; LN877321; CUA55064.1; -; Genomic_DNA.
DR EMBL; LN877349; CUA55092.1; -; Genomic_DNA.
DR EMBL; LN880521; CUI25654.1; -; Genomic_DNA.
DR EMBL; LN999579; CUX90972.1; -; Genomic_DNA.
DR EMBL; LN999622; CUX91015.1; -; Genomic_DNA.
DR EMBL; MH269339; QAX33599.1; -; Genomic_DNA.
DR EMBL; MK394308; QBM15334.1; -; Genomic_DNA.
DR EMBL; MK203042; QCP66133.1; -; Genomic_DNA.
DR EMBL; MK203046; QCP66137.1; -; Genomic_DNA.
DR EMBL; MK938087; QDK61684.1; -; Genomic_DNA.
DR EMBL; MK938117; QDK61714.1; -; Genomic_DNA.
DR EMBL; MK938167; QDK61762.1; -; Genomic_DNA.
DR EMBL; MK938170; QDK61765.1; -; Genomic_DNA.
DR EMBL; MK938173; QDK61768.1; -; Genomic_DNA.
DR EMBL; MK954845; QDK61777.1; -; Genomic_DNA.
DR EMBL; MK954876; QDK61807.1; -; Genomic_DNA.
DR EMBL; MK954888; QDK61819.1; -; Genomic_DNA.
DR EMBL; MK954889; QDK61820.1; -; Genomic_DNA.
DR EMBL; MK954949; QDK61880.1; -; Genomic_DNA.
DR EMBL; MK955023; QDK61953.1; -; Genomic_DNA.
DR EMBL; MK955047; QDK61977.1; -; Genomic_DNA.
DR EMBL; MK955062; QDK61992.1; -; Genomic_DNA.
DR EMBL; MK955085; QDK62014.1; -; Genomic_DNA.
DR EMBL; MK955099; QDK62027.1; -; Genomic_DNA.
DR EMBL; MK955110; QDK62038.1; -; Genomic_DNA.
DR EMBL; MK955136; QDK62064.1; -; Genomic_DNA.
DR EMBL; MN015829; QDK62077.1; -; Genomic_DNA.
DR EMBL; MN015909; QDK62157.1; -; Genomic_DNA.
DR EMBL; MN015939; QDK62187.1; -; Genomic_DNA.
DR EMBL; MN015941; QDK62189.1; -; Genomic_DNA.
DR EMBL; MN015966; QDK62214.1; -; Genomic_DNA.
DR EMBL; MN015996; QDK62244.1; -; Genomic_DNA.
DR EMBL; MN016060; QDK62308.1; -; Genomic_DNA.
DR EMBL; MN016082; QDK62330.1; -; Genomic_DNA.
DR EMBL; MN016140; QDK62386.1; -; Genomic_DNA.
DR EMBL; MN166913; QEQ28464.1; -; Genomic_DNA.
DR EMBL; MK953656; QGN03558.1; -; Genomic_DNA.
DR EMBL; MN787263; QGY64059.1; -; Genomic_DNA.
DR EMBL; MN812891; QGY64085.1; -; Genomic_DNA.
DR EMBL; MT015539; QIA48961.1; -; Genomic_DNA.
DR EMBL; MN154525; QIA58934.1; -; Genomic_DNA.
DR EMBL; MK966412; QIE06070.1; -; Genomic_DNA.
DR EMBL; MT267960; QIS93203.1; -; Genomic_DNA.
DR EMBL; MT503584; QMI58388.1; -; Genomic_DNA.
DR EMBL; MT503585; QMI58389.1; -; Genomic_DNA.
DR EMBL; MT503586; QMI58390.1; -; Genomic_DNA.
DR EMBL; MT503589; QMI58393.1; -; Genomic_DNA.
DR EMBL; MT550912; QMI58458.1; -; Genomic_DNA.
DR EMBL; MT601710; QMI58487.1; -; Genomic_DNA.
DR EMBL; MT601730; QMI58507.1; -; Genomic_DNA.
DR EMBL; MT604095; QQP18455.1; -; Genomic_DNA.
DR EMBL; MZ374119; QXH29492.1; -; Genomic_DNA.
DR EMBL; MZ359128; QXU63159.1; -; Genomic_DNA.
DR EMBL; LT596644; SBV08748.1; -; Genomic_DNA.
DR EMBL; LT599182; SBW38403.1; -; Genomic_DNA.
DR EMBL; LT599194; SBW38415.1; -; Genomic_DNA.
DR EMBL; LT838207; SMB18742.1; -; Genomic_DNA.
DR EMBL; LT838208; SMB18743.1; -; Genomic_DNA.
DR EMBL; LT898181; SNQ25991.1; -; Genomic_DNA.
DR EMBL; LS398203; SPQ44332.1; -; Genomic_DNA.
DR EMBL; LR701992; VVT62740.1; -; Genomic_DNA.
DR PDB; 7TLT; X-ray; 2.30 A; A/C=1-365.
DR ProteomicsDB; 2789; -.
DR Ensembl; ENST00000456012.5; ENSP00000408986.1; ENSG00000231834.10.
DR Ensembl; ENST00000550728.2; ENSP00000450169.1; ENSG00000231834.10.
DR UCSC; uc011gqx.2; human.
DR HGNC; HGNC:4931; HLA-A.
DR ChiTaRS; HLA-A; human.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProt.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt.
DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd21027; IgC1_MHC_Ia_HLA-A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR InterPro; IPR010579; MHC_I_a_C.
DR PANTHER; PTHR16675:SF229; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7TLT};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:B0UXQ0,
KW ECO:0007829|MaxQB:B0UXQ0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..365
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015087008"
FT TRANSMEM 306..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 338..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 125..188
FT /evidence="ECO:0007829|PDB:7TLT"
FT DISULFID 227..283
FT /evidence="ECO:0007829|PDB:7TLT"
SQ SEQUENCE 365 AA; 40841 MW; 4276F0222DE71589 CRC64;
MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ
MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
TACKV
//
