ID B0UXS3_DANRE Unreviewed; 624 AA.
AC B0UXS3; A0A8M1NJM0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=HMG box domain-containing 4a {ECO:0000313|Ensembl:ENSDARP00000112627};
DE SubName: Full=HMG domain-containing protein 4 {ECO:0000313|RefSeq:NP_001120984.1};
GN Name=hmgxb4a {ECO:0000313|Ensembl:ENSDARP00000112627,
GN ECO:0000313|RefSeq:NP_001120984.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070912-675};
GN Synonyms=si:dkeyp-69e1.7 {ECO:0000313|RefSeq:NP_001120984.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000112627};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000112627, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000112627};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000112627}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000112627};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001120984.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001120984.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR383684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001120984.1; NM_001127512.1.
DR STRING; 7955.ENSDARP00000112627; -.
DR PaxDb; 7955-ENSDARP00000112627; -.
DR Ensembl; ENSDART00000133523; ENSDARP00000112627; ENSDARG00000075783.
DR Ensembl; ENSDART00000133523.2; ENSDARP00000112627.1; ENSDARG00000075783.5.
DR GeneID; 559742; -.
DR KEGG; dre:559742; -.
DR AGR; ZFIN:ZDB-GENE-070912-675; -.
DR CTD; 559742; -.
DR ZFIN; ZDB-GENE-070912-675; hmgxb4a.
DR eggNOG; ENOG502QSH9; Eukaryota.
DR HOGENOM; CLU_032486_0_0_1; -.
DR OMA; HTHGPAN; -.
DR OrthoDB; 2917084at2759; -.
DR PhylomeDB; B0UXS3; -.
DR TreeFam; TF106404; -.
DR Proteomes; UP000000437; Chromosome 3.
DR Bgee; ENSDARG00000075783; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21982; HMG-box_HMGXB4; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR025228; DUF4171.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR042477; HMGXB4.
DR InterPro; IPR048016; HMGXB4_HMG-box.
DR PANTHER; PTHR46584; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46584:SF1; HMG DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13775; DUF4171; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 429..497
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 429..497
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68042 MW; 381879F133FA620D CRC64;
MAFEEIRKKG MMDVPGAEGE VSLVAGRSQR EKKRSYKDLL REEEEIAAQV CKTSKKHHKD
SELFLLGGDS HKKKKKHSSD DYYHRDHHSS GQPPHKKKRK SSDRSPSLTS SSSSHPSHTT
DTAMGLLEAI TSPLATGSEP PPHLHKKPSY PQHASSHSSK ERKRDGSSKN SSHSYPHSRP
PGSSSSKKHS SSSSKSLLFH GGAAKGEPLT LCEAEGLKMK LILSSKEKSE GAGVNDFPGQ
SSSSSSGVAG HHSSSGSKKG GIKKEKDKEK DKMMSKPPKK KQHIREPLPV VGKEVEVEGM
GGESSSSGGE LEAGELVIDD SYTRLSKKKK KSKKSKKKKD KERDRDREKG SREKKHSKGG
SGGKKSSQGD QPRSHSHTHS SSNHSSSGGM YPMAPPTSSH QHQSIELIGE KKKKKEEKER
DKHDKDKPKK KNMTAYQVFC KEYRVNINAE QPGLVFGELS KKLAEVWKQL PEKDKLVWRQ
KAQYLQHKQN KAEAMTVKRK TLTTSDSKSK GSSKAFSLGS GLAPQGRSSL GMSLSPARVP
DVDPIDAAAH LQLLGESLSL IGHRLQETEG MVAVSGSLSV LLDSILCALG PLTCLTAQVP
QLNGCPRNIL SNTLDNIAYI MPGL
//
