ID MUTS_ACIBY Reviewed; 881 AA.
AC B0VAU7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ABAYE2476;
OS Acinetobacter baumannii (strain AYE).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=509173;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AYE;
RX PubMed=18350144; DOI=10.1371/journal.pone.0001805;
RA Vallenet D., Nordmann P., Barbe V., Poirel L., Mangenot S., Bataille E.,
RA Dossat C., Gas S., Kreimeyer A., Lenoble P., Oztas S., Poulain J.,
RA Segurens B., Robert C., Abergel C., Claverie J.-M., Raoult D., Medigue C.,
RA Weissenbach J., Cruveiller S.;
RT "Comparative analysis of Acinetobacters: three genomes for three
RT lifestyles.";
RL PLoS ONE 3:E1805-E1805(2008).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CU459141; CAM87320.1; -; Genomic_DNA.
DR RefSeq; WP_001083258.1; NC_010410.1.
DR AlphaFoldDB; B0VAU7; -.
DR SMR; B0VAU7; -.
DR EnsemblBacteria; CAM87320; CAM87320; ABAYE2476.
DR KEGG; aby:ABAYE2476; -.
DR HOGENOM; CLU_002472_4_0_6; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..881
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000093603"
FT BINDING 627..634
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 881 AA; 97893 MW; 76D9D87566013815 CRC64;
MNSAEIMADL SNHTPMMQQY LKVKKDYQHA LLFYRMGDFY ELFFEDAHLA AKLLGITLTH
RGKANGNPIP MAGVPYHSAE GYLARLVKAG RTVAICEQVG EVTGKGPVER KVVRILTPGT
LTDDALLTSY QSSNLVALCI HQNQIGFALL DLSAGIFKVQ QQDYKPEQLP IELARLMPSE
ILIDEDLVDP NIIEQIKKHL DCPVTKRPNV DFNLNNAQKT LCDQFSVSTL SGFGLDPLPL
AKAAAAALIH YAKETQKTAL PHIRSILLEQ SSDFIALDPI TRRNLEIIEP LFEHGTSLFQ
LVNDCQTAMG GRLLSRTLMQ PVRDTALLDA RLDAIEQLIQ GYHESPVRLV LKEIGDIERV
LSRVALGSAR PRDLVQLRHA CAQIPFLRNA LAPVVQAKKS KLLGQLDQEL GDFKSLHQHL
MAAIVENPPV LLRDGNVIAE GYDAELDELR QIRDHAGQFL IDLEIKERER TGISTLKIGY
NRVSGYYIEL TRAQAEQAPA DYIRRQTLKN AERYITPELK SFEDKVLSSE SRALAREKAL
FEALLENLRE NIAHLQMMSS AIAQIDVIAN FAHQARLNNW ARPEFTPETG IKIQGGRHPV
VEALSKAPFT PNDTFLDVQH RMAIITGPNM GGKSTFMRQT ALISLLAYCG SYVPARAAKL
GPIDRIFTRI GSADDLSTGK STFMVEMTET SQILHHATNQ SLVLMDEVGR GTSTYDGLSL
AWACVVDLTK RVKCLCLFAT HYFELTELGS EPGIDNYHVT AQELNGNLIL LHKVQQGPAS
QSHGLQVAKL AGIPANVIKE AQKRLRILEK QQQQHLQTSV QSDLFATLDS EVTPSTQVIE
KVIEVEVSSP ALDLLKQIEV DNLTPRQALE QLYELKAALN S
//
