ID B0VZY3_CULQU Unreviewed; 1372 AA.
AC B0VZY3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=CD109 antigen {ECO:0000313|EMBL:EDS37555.1};
GN Name=6031174 {ECO:0000313|EnsemblMetazoa:CPIJ000347-PA};
GN ORFNames=CpipJ_CPIJ000347 {ECO:0000313|EMBL:EDS37555.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS37555.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS37555.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ000347-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ000347-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; DS231816; EDS37555.1; -; Genomic_DNA.
DR RefSeq; XP_001842017.1; XM_001841965.1.
DR STRING; 7176.B0VZY3; -.
DR EnsemblMetazoa; CPIJ000347-RA; CPIJ000347-PA; CPIJ000347.
DR KEGG; cqu:CpipJ_CPIJ000347; -.
DR VEuPathDB; VectorBase:CPIJ000347; -.
DR VEuPathDB; VectorBase:CQUJHB008107; -.
DR eggNOG; KOG1366; Eukaryota.
DR HOGENOM; CLU_001634_5_3_1; -.
DR InParanoid; B0VZY3; -.
DR OMA; ICDEEDC; -.
DR OrthoDB; 3431519at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR049135; TEP1_CUB2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR Pfam; PF21412; TEP1_CUB2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1372
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011407249"
FT DOMAIN 439..574
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 640..732
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1257..1350
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1372 AA; 155030 MW; 2835DFB44D4CB09E CRC64;
MWVLELLILG ICFIGYCKGQ GFSAIGPNTI RPNTPYSISF TNSFPCHAPV DVTLQGGPVG
CKLSINQTIS AIVSRRTGKS VSFEVGNIAK GNYKVLVRSK DVGIPFNEEI DLAYDGKTES
IFILLDKPVY KPGDVLKFRI VVVDVNTRPA SDIKTVNVTL SDANGNSIRR WPFGKLQHGV
FESQVQLASS PTLGLWSFTV MTGRSKASKS LELREYVLPK YHVKVYPQRA LLVTEKRIVL
VVETAYTSGK PLEGSLTVDL FVDDASKRRP DYFTTKRIEG QTTVEFRLND ELEVESDSDV
TFVFARVNVT ETFTNRTESI VERIPVHRYP NTISVVKSDH LFSPGSLFSL QLIVQDHNGI
PASDGQSATI KIIYDGDESG EESYEISLVK ETDSKGVITV DIVPPRTAIS FQMEITYDSI
VYDNFEEIYA AQSESNQFIT VTLNENRYKV RPNREVLFEI SCTERMSHFA YTFWARGSII
DSGHVNVANK KRYSFRYRLL PQMAPKAKLI VTYTSKNFLI FDDLELNFDM FSNHFEFSLD
DDDYLPGQDI YVDLQAANDS YVAFHAIDQS VLHLGRNGHA FTQDDVLRDL KQYGVGESDE
FEPFNVLLTA YARNHHSRSS RSSEKIDKAP TQIRTVFPET WLWTNYSMDG KRSFMTIESV
VPDTVTSWMV DGFALSPTLG LGVMKQPRVF TVNQPFYIIA DLPYSIKRDE VVVIQVTVFN
FLGTTLTSDV TLFNKNDEIE FVDNYVEFES ATDVTLSDMN VRAVETQVTR RTKPVIVPAN
NGKSVSFMIK AKKLGDIAIK FEAVNTLKSD SVEHMLRVVP ESHLHELNEA RYIDLSETNY
QKFDISINVP RNVDEGSVSV KFILDPDIFG SVVENLESLI SLPCGCGEQN MIQLVPNVVV
LDYMYETRTI KEELYSDLIS KLTKGYENQL NYKLSDNSFA VFPEMRGCVF LTAFVAKSFA
IASKYIYIDE RVIEGALDWL VQTQQPDGRF EEIGDIIHVD MQGGLETSCF SLTAYVLIAL
LESKSVNGER WEILQKSADY LTTGLDSINN PYDLALATYA LSLKDRNESL PFLDKLVEFS
QYDEATGTRS WSYHSLGVEI AGYALLSYIE HGLVPDATPI MRWLTTQRYD RGGFMSTQDT
FVALKAMAKF SARVSTHRND YRVAVIPKRD KMYLFDVDSQ SLNTLKQNLE STTRKVQVEL
LGKGAGIFQI SYQYYQNIVV EKSSFNLEVN LLPNSTYYRQ ELNVCVSFNA KEAYEYSNMA
LVEVFFPSGL VADKNSVRDL SIGRNIKKTE LRFGGTSLVV YYIRLNAQPN CFVVSAERHF
KVALHRPAHV VVYDYYDNGA QSDRFAIATY EGKVMQMCDV CDDEDCETLS CP
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