ID B0W300_CULQU Unreviewed; 498 AA.
AC B0W300;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Cytohesin 1, 2, 3, 4 {ECO:0000313|EMBL:EDS30359.1, ECO:0000313|EnsemblMetazoa:CPIJ001600-PA};
GN Name=6032494 {ECO:0000313|EnsemblMetazoa:CPIJ001600-PA};
GN ORFNames=CpipJ_CPIJ001600 {ECO:0000313|EMBL:EDS30359.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS30359.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS30359.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ001600-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ001600-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; DS231829; EDS30359.1; -; Genomic_DNA.
DR RefSeq; XP_001843084.1; XM_001843032.1.
DR AlphaFoldDB; B0W300; -.
DR STRING; 7176.B0W300; -.
DR EnsemblMetazoa; CPIJ001600-RA; CPIJ001600-PA; CPIJ001600.
DR KEGG; cqu:CpipJ_CPIJ001600; -.
DR VEuPathDB; VectorBase:CPIJ001600; -.
DR VEuPathDB; VectorBase:CQUJHB008811; -.
DR eggNOG; KOG0930; Eukaryota.
DR HOGENOM; CLU_547750_0_0_1; -.
DR InParanoid; B0W300; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF406; MIP16918P; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 244..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..147
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 245..346
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 364..479
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 498 AA; 57394 MW; 0E956B4E98D6F3B5 CRC64;
MTGKCNVYIN KPTRTSRLFT NAFGTNAVGS HTIKMINSFQ YSDYLGEKND FNEQVLKAFV
DLHDFSNLIL VQALRQFLWS FRLPGEAQKI DRMMECFAQR YCQLNPDIFT NTDTCYVLSF
AIIMLNTSLH NPSSNIDRQI GLTADEFGVD ARFDHHFQHS LVLRNAGTLL QQLDHILQRL
PIRPDENRPT NLPLQEQLCH GQYFDAQHYH RGGSITASSS WVRAIIIILF ATGCWDVISS
RIIFLSLVIT ILTIWSISMY SALTRFSIRF RPEFQTFDAI YTCSCGGGEF EESRNRPGVD
ICVVIAAPVK EKPTVEQFIS MNRGINNGGD LPRELLESLY ESIRTEPFKI PQDDGNDLMH
TFFNPDKEGW LWKQGGRYKS WKRRWFILND NCLYYFEYTT DKEPRGIIPL ENIAVREVQD
RSKQFCFELH ASGGAEIIKA CKTDSEGKVV EGKHTVYRMS AASEEEQREW IKCLNQSISH
NPFHDILVQR KKKALAKM
//
