ID B0W3T1_CULQU Unreviewed; 495 AA.
AC B0W3T1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Rho/rac/cdc GTPase-activating protein {ECO:0000313|EMBL:EDS32229.1, ECO:0000313|EnsemblMetazoa:CPIJ002097-PA};
GN Name=6032828 {ECO:0000313|EnsemblMetazoa:CPIJ002097-PA};
GN ORFNames=CpipJ_CPIJ002097 {ECO:0000313|EMBL:EDS32229.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS32229.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS32229.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002097-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002097-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS231833; EDS32229.1; -; Genomic_DNA.
DR RefSeq; XP_001843366.1; XM_001843314.1.
DR AlphaFoldDB; B0W3T1; -.
DR STRING; 7176.B0W3T1; -.
DR EnsemblMetazoa; CPIJ002097-RA; CPIJ002097-PA; CPIJ002097.
DR GeneID; 6032828; -.
DR KEGG; cqu:CpipJ_CPIJ002097; -.
DR VEuPathDB; VectorBase:CPIJ002097; -.
DR VEuPathDB; VectorBase:CQUJHB012322; -.
DR eggNOG; KOG4406; Eukaryota.
DR HOGENOM; CLU_030214_0_0_1; -.
DR InParanoid; B0W3T1; -.
DR OMA; PTRVREY; -.
DR OrthoDB; 3030820at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 107..262
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 293..483
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 21..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 57678 MW; 63C3F4865003CDB5 CRC64;
MEAFEQKNNV NLPVKFPGAP MNPPLVDNGE DPHPSLSDWH DYEPNLEFDD TELSQTAPEP
GGTVIFDEDN FSGEFDVVSE DEIIKTTLDP DNYEEQLKMV EPDENAIRKE FKRRKFIEFI
GTDKHGQPII AIYACSLPER KDLNTNIFID FIIKSMEEFV QNDYIIAYFH QGMKDNNKPS
LQFLWNSYKE LDRSFKKNLK KLYVVHPTTF IKMVWFFFKP VISEKFKSKL IYTSSLDELK
QSLGLNTLKV PDTVREFDEK INNSSRYTLR GSKTSLKASR SSEHIPRTHQ FGVTLRFIIE
NSACLNCIPP IVRKCVDHLS LSNVIDTEGI FRRSGNYNRI KELREKINQG DGEVNLMNED
THVVAALLKT FLRELEEPLL TYELYDDIVQ FAEWTTEEQR SRNVKQILRE KLPEENYELF
KYIVEFLGKI MERKDFNKMT SSNLAIVFGP NLVWPKQAQM SLDEIGPINA FIDYVLQNQD
DIYFVDINKK DGAYD
//
