ID B0W4A3_CULQU Unreviewed; 757 AA.
AC B0W4A3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Disheveled-associated activator of morphogenesis 2 {ECO:0000313|EMBL:EDS33188.1, ECO:0000313|EnsemblMetazoa:CPIJ002006-PA};
GN Name=6033039 {ECO:0000313|EnsemblMetazoa:CPIJ002006-PA};
GN ORFNames=CpipJ_CPIJ002006 {ECO:0000313|EMBL:EDS33188.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33188.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33188.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002006-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002006-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; DS231836; EDS33188.1; -; Genomic_DNA.
DR RefSeq; XP_001843545.1; XM_001843493.1.
DR AlphaFoldDB; B0W4A3; -.
DR STRING; 7176.B0W4A3; -.
DR EnsemblMetazoa; CPIJ002006-RA; CPIJ002006-PA; CPIJ002006.
DR KEGG; cqu:CpipJ_CPIJ002006; -.
DR VEuPathDB; VectorBase:CPIJ002006; -.
DR VEuPathDB; VectorBase:CQUJHB004638; -.
DR eggNOG; KOG1922; Eukaryota.
DR HOGENOM; CLU_002356_2_0_1; -.
DR InParanoid; B0W4A3; -.
DR OMA; KENHKER; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45725:SF1; DELPHILIN; 1.
DR PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 41..431
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 648..757
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 430..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 470..567
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 591..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 84413 MW; 77A7CD97DE6F0795 CRC64;
MNPDNFFIKI FENRHQKSDD EPPEICVVEG VFSLQTLTPT QPMPAIDELD SKFAELVEEL
DLTAPNKAAM LGLPPQKKWQ IYCSRKSPLE GVTGPNGAPL PGATLPPTPE HYIERLKDMA
VQLKASAPDD SPSHEYGPKI ESHTALFDAL KTALRTSAHS FVIRFIELQG LPALLELLQA
LDIRVANSPL HTSLIGCIKA LMNNSTGRSH VLAHPTGIDT IARSLAADNI KTKIAALEIL
GAVCLVPGGH KKVLTAMLNY QEYAAERARF QGIVNDLDKS TGAYRDDVNL KTAIMSFINA
VLNYGPGQEN LEFRLHLRYE FLMLGIQPVI DKLRKHENET LNRHLDFFEM VRNEDEKELA
RKFNHEHVDT KSATAMFDLL RRKLSHSGAY PHLLSLLQHL LLLPHGGPNA QHWLMFDRVV
QQIVLQQEER PTSEIIDPDA QDKTSETSSL KLQDPDAAPL QIDVRKIVKL LVKEEELVAA
RTRAEDLEKE NSDINAKLAK KEQELDLRTQ EKEDLETSLA RMRERLEKES ANHSQAVQRA
MNAEMRAEDL QHRFVSEQQE RVRLERLVTE GSIPDDQKVA GLQGGCGANG AVSPPPPPPP
CKLPPPPPPM MAAPPPPPAP GGLPKMNAML PNQMAANHPA PPKMEAPKKN VPQPANPLKS
FNWSKLPDSK LQGTVWSELD DTRWYNSIEL ESIDKLFSAY QKNGVANDGS IEDLRLIGKA
KTKILSVIDG RRAQNCTILL SKLKMSDEEI SKYYQKL
//
