ID B0W5B3_CULQU Unreviewed; 413 AA.
AC B0W5B3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Sphingomyelin synthetase {ECO:0000313|EMBL:EDS35233.1, ECO:0000313|EnsemblMetazoa:CPIJ002232-PA};
GN Name=6033454 {ECO:0000313|EnsemblMetazoa:CPIJ002232-PA};
GN ORFNames=CpipJ_CPIJ002232 {ECO:0000313|EMBL:EDS35233.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS35233.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS35233.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002232-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002232-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; DS231842; EDS35233.1; -; Genomic_DNA.
DR RefSeq; XP_001843901.1; XM_001843849.1.
DR AlphaFoldDB; B0W5B3; -.
DR EnsemblMetazoa; CPIJ002232-RA; CPIJ002232-PA; CPIJ002232.
DR KEGG; cqu:CpipJ_CPIJ002232; -.
DR VEuPathDB; VectorBase:CPIJ002232; -.
DR VEuPathDB; VectorBase:CQUJHB004310; -.
DR eggNOG; KOG3058; Eukaryota.
DR HOGENOM; CLU_027104_1_1_1; -.
DR InParanoid; B0W5B3; -.
DR OMA; GSRCERH; -.
DR OrthoDB; 1343173at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..53
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 413 AA; 47037 MW; B0AD1A5741FC6E7A CRC64;
MANELAVINW TRENVAEWAR KEGLNRKIFD LIVKEEIDGK ALLTLSENDI KSLRENYAYA
LTLGDIKRFW FSVRLVQRQN VTTLAYLGML PLGGNGSHTI DSGVPGHHHH HPLLSSLGTS
YASADINFSE IERISPPMSI DGRATCIQPE FFKTMISLGY AFLVTWITAF VMVVVHERVP
DMKKYPPLPD IFLDNVPHIP WAFHMCEVTG TLLFCIWVCV LIVHKHRMVL LRRFFALAGT
VFLLRCVTML ITSLSVPGTH LECTKNDHKF DDSTAEITEM IYLRVSRAYT IWSGLGMSIQ
GVRTCGDYMF SGHTVALTLL NFFITEYTPR NLYFLHTLTW LLNMFGIFFI LAAHEHYSID
VFVAFYISSR LFLYYHTLAN NQIESSNIRC SHRASSPSCS FAIDLIVQSA CLK
//
