ID B0W645_CULQU Unreviewed; 372 AA.
AC B0W645;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Rhomboid-like protein {ECO:0000313|EnsemblMetazoa:CPIJ002510-PA};
GN Name=6033773 {ECO:0000313|EnsemblMetazoa:CPIJ002510-PA};
GN ORFNames=CpipJ_CPIJ002510 {ECO:0000313|EMBL:EDS36392.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS36392.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS36392.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002510-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002510-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family.
CC {ECO:0000256|ARBA:ARBA00009045, ECO:0000256|PIRNR:PIRNR037470}.
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DR EMBL; DS231847; EDS36392.1; -; Genomic_DNA.
DR RefSeq; XP_001844179.1; XM_001844127.1.
DR AlphaFoldDB; B0W645; -.
DR STRING; 7176.B0W645; -.
DR MEROPS; S54.012; -.
DR EnsemblMetazoa; CPIJ002510-RA; CPIJ002510-PA; CPIJ002510.
DR GeneID; 6033773; -.
DR KEGG; cqu:CpipJ_CPIJ002510; -.
DR VEuPathDB; VectorBase:CPIJ002510; -.
DR VEuPathDB; VectorBase:CQUJHB005633; -.
DR eggNOG; KOG2289; Eukaryota.
DR HOGENOM; CLU_048023_1_0_1; -.
DR InParanoid; B0W645; -.
DR OMA; WIAVIFY; -.
DR OrthoDB; 2872779at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR017213; Peptidase_S54_rhomboid_met.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR PANTHER; PTHR45840:SF8; RHOMBOID PROTEASE; 1.
DR PANTHER; PTHR45840; RHOMBOID-RELATED PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR PIRSF; PIRSF037470; Rhomboid; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 142..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..66
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 68..103
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT ACT_SITE 255
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR037470-50"
FT ACT_SITE 314
FT /evidence="ECO:0000256|PIRSR:PIRSR037470-50"
SQ SEQUENCE 372 AA; 42945 MW; 0742C7D43762D337 CRC64;
MAAYLNNQQQ VQLPPHEIIP LQRMTTREEL DERQRIRDIF DKYDRDHTGN LSVQELKRMI
NSRRCPDLPK GFAKKLMKAA DHNNDGYLDF EEFYQMSREH NYLFRDMCVR YCRLVVPSRN
PVAADEPDGE YERSMTFWPP PLTMIVFSIV EIIFFVIDII ETNNQQGTST SGPMATLFIY
SPQLREQAWR FVTYMFVHIG FMHIVMNLLV QIFLGVALEL VHCWWRVALV YLAGVLAGSM
GTSIFSPRVF LAGASGGVYA LITAHIATII MNWGQMEYAI VQLFVFLVFC VTDLSVSIYN
SIYDPFDKVG YIAHASGALA GFLVGIGVLR NLKVNRWERY LWWCAVTIYF MLMGAGVLYH
IFNPDHFYPV FA
//
