ID B0W690_CULQU Unreviewed; 886 AA.
AC B0W690;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=6033830 {ECO:0000313|EnsemblMetazoa:CPIJ002555-PA};
GN ORFNames=CpipJ_CPIJ002555 {ECO:0000313|EMBL:EDS36437.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS36437.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS36437.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ002555-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ002555-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DS231847; EDS36437.1; -; Genomic_DNA.
DR RefSeq; XP_001844224.1; XM_001844172.1.
DR AlphaFoldDB; B0W690; -.
DR STRING; 7176.B0W690; -.
DR EnsemblMetazoa; CPIJ002555-RA; CPIJ002555-PA; CPIJ002555.
DR GeneID; 6033830; -.
DR KEGG; cqu:CpipJ_CPIJ002555; -.
DR VEuPathDB; VectorBase:CPIJ002555; -.
DR VEuPathDB; VectorBase:CQUJHB015510; -.
DR eggNOG; KOG0477; Eukaryota.
DR HOGENOM; CLU_000995_0_1_1; -.
DR InParanoid; B0W690; -.
DR OMA; TYERVTT; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 459..665
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 100554 MW; 4455DB3EE7A44678 CRC64;
MSDNPSSPPP NTPSDIDRRN FRSGMTSPVG DFEPFENEEE ILGDMTIRED NYDEDEEGEE
LFGDNMENDY RAMPELDQYD IANLDQEDYN DISQTDRAAA EAEMRRRDRA AGIHRDKRDL
FYEKSDDEDD VPRAKRRAAE KAAQGGEVED AEMIESIENL EDTKGHSIKE WVSMLGPRTE
IANRFNSFLR TFVDGKGQYV YRDRIRRMCE QNKSSFVVSY TDLANNQHVL AYFLPEAPFQ
MLEIMDKVAK EMVLSIYPTY ERVTNEVHVR ISDLPLVEEL RTFRKLHLNQ LVRTLGVVTA
TTGVLPQLSV IKYDCVKCGY VLGPFVQSQN TEVKPGSCPE CQSGGPFSIN MEQTLYRNYQ
KITLQESPGR IPAGRIPRSK DCILLSDLCD QCKPGDEIEV TGIYTNNYDG SLNTEQGFPV
FATVLIANHM VVKDSKQVVA SLTDEDIATI QKLSKDPRIS ERIIQSMAPS IFGHDYIKRS
LALTLFGGEA KNHGEKHKLR GDINILLCGD PGTAKSQFLK YSEKIAPRAV FTTGQGASAV
GLTAYVRRNP ATREWTLEAG ALVLADQGVC LIDEFDKMND QDRTSIHEAM EQQSISISKA
GIITSLQARC AVIAAANPIG GRYDPSMTFS ENVNLSEPIL SRFDILCVVK DEFDPMQDQH
LARFVVGSHI KNHPTMEETI PESQPTDSMQ IPQDLLKKYI VYSKENVHPK LTNMDQDKIA
KMYSQLRQES LSTGSLPITV RHIESVIRMS EAHARMHLRD TVQDVDVNMA IRMMLESFIE
AQKFSVMKKM RSTFQKYLSF QKDHSELLFF ILRQLTLDQL AYLRCKEGPR ATHVEVMEKD
LIERAKAIDI HNMKQFYESE LFKKNGFSYD AKRKTILQIV PEAAEA
//
