ID B0W7P9_CULQU Unreviewed; 2152 AA.
AC B0W7P9;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Regulator of presynaptic morphology protein {ECO:0000313|EMBL:EDS38193.1, ECO:0000313|EnsemblMetazoa:CPIJ003145-PA};
GN Name=6034415 {ECO:0000313|EnsemblMetazoa:CPIJ003145-PA};
GN ORFNames=CpipJ_CPIJ003145 {ECO:0000313|EMBL:EDS38193.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS38193.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS38193.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ003145-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ003145-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS231855; EDS38193.1; -; Genomic_DNA.
DR RefSeq; XP_001844733.1; XM_001844681.1.
DR STRING; 7176.B0W7P9; -.
DR EnsemblMetazoa; CPIJ003145-RA; CPIJ003145-PA; CPIJ003145.
DR KEGG; cqu:CpipJ_CPIJ003145; -.
DR VEuPathDB; VectorBase:CPIJ003145; -.
DR VEuPathDB; VectorBase:CQUJHB018024; -.
DR eggNOG; KOG1428; Eukaryota.
DR HOGENOM; CLU_000562_1_0_1; -.
DR InParanoid; B0W7P9; -.
DR OMA; EYCNSSH; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR CDD; cd19799; Bbox2_MYCBP2; 1.
DR CDD; cd16463; RING-H2_PHR; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45943; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR PANTHER; PTHR45943:SF1; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1114..1293
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1912..1963
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 435..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1561..1583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2152 AA; 238812 MW; 545DDE6EFC1CE7BB CRC64;
MGSIVTGEQS YEKQFLKDFI YVAAGSPGAR LAAWLQPESR LDPNKCEIKM SQEPLRCGWP
SHFIIETRDQ YGDEIFVPGI KIEVKASLGS NLISEGNRKM HMKSRNDSLY LGGAALPPKI
GYECTFKEKE KSCLKAITAM KPYQPYSFEE LRYCNTIQSK TTEILTANDL GNNTYGVFWT
PRVPGNYSLT ITIDGVCVEE IYRVDVIDAG LPPLSQETTL KKVQPPTKLR KFIAKNSAGL
RVRLHPTLQS DQIGIVKLNG IVSYIDEMEN DDGLWVRLST ESIREHCTSS WFPTEAWCLQ
YNQHLGKTLL HPILESSSTK ALMEQVDQSS PTTSDANEEN ENTIDYFDFM KTDRPTDEAS
SANDGEELVA AAKLLQITEQ PPTTDESPAN AAAAAAAAAN INIANLNQSN IGAAIAGVVG
GGAKKMQALQ KWLKGDSFEE NESPRKRKSE GHDPRSLGNR SFDRSRSVSP EIFSHGNFSA
SIPPFNSKSL KIESKELPKR ALSPSIAETL RAVFSAFLWH EGLVHDAMAC ASFLKFHPSI
SKKESENMPS SLKSNKSTEE KSANNPKAAN QKKVEDGCWC ELCDVFLPIP VTYHMRIVHP
GCGKYAKGKG YNSIGVYCEG WAGNCGDGGQ GVSSWYLIYV NTAKVSNNVN FNGANQTGGK
GEGGSNILLG FGAESTIPSE LFTIMKENSF FLLELNSYNG ELMWPPPELL ASMETLGAKT
NNDLTCDLLG MNLGDMHAYD FKVIEDLSME AADSYMKNIQ TSPAIPSTSK FHRSFSMGQG
WNTPQNKLAT EYNPVGKGEI GGKGDGPCNV VMRRKKQCTC TSGDSNLLNY PSVNLQKLVP
EHLLNNSLVK ENIPNSRSKN KVNNKINDKN NLQTNPRATL LASGKRPEEI NFSEFLEMYH
SNARESSEKL KNVDEKSDGS GSGSSGNSAY KLDVQAGALS LLNRPSMIFM LEKHDLKKLR
HLMTRNLRKT ICNIYSLQAL NWLLRSVTQP IGLHDIMWWF ISSLSYSTHD CEDEPKLDEG
VLGLEHPGSN QFNGPLSQTL SQSLHSLLHT IADLTLLLPS GSSLQKTAVQ CFGLKFKQSD
HQFLHRSHVF GNISKILSKS EEQNDENLLP SVAMFNSYSN AVDVFTEECI RISMLSDITE
IFDLVVSSRP ALANSLIDNS TETFWESDEE DRNKPKIIEL TMNRTNYHCK VICIHIDNSR
DIGNKVSSIL LYGGSSFGET SLLKTIDVDP LVCSWISATI SDDECTHYRM EFRGPEATLR
VRQIKLLGYT AEDKASQFKH NLKHTSANYI QQKNCEAETL RVFRLLTGQV FGKLILESGK
NFGANTPTSS KITESTVISS STESLDLREH MVGILFSRSK LSHLQKQIIV HIVHAIQKEA
LRSREEWEHN VMFSADNETD FEENLKLNDT YCFEMLSMVL ALSGSAVGRS YLSHQHGLLK
DLFSLLHTGS DRVQRQVTAL IRRILPEISP ETLCELLGVE KVPEIDFNLL SQNNEMFNMN
KCGILDIFLA VIAKALQVQI KVKNNSNKNP PTMKLWRYMN ICKIDDYEKS TLNKLSMTNS
QFSNAESDRP GGATGQRDNS PAAEQYDFEG SSSEFLDDKT NDDNSVDFDG VGAVCSSKPG
IRIETVGVKP RWFLNGTISS KQADNIMTLI RDMAHGKLSE KWSLITKAAI AECILNITRL
SDVYRVPETC MTTPTLWLAL ASLCVLDRDH VEKLSSSQWS KQSESRPLCS NHDDDVTYAM
IICSLCGSLC SDCDRFLHLN RKTRNHYRTV CKEEEEAIRV ELHESCGRAK LFWLLALVDS
KTLKGMLEFR NGNNTLVCDP PNAAIGVCRF CGVTGSTGLL AVGNVCVDQQ CQEYAASACA
KIHPCGHLCG GIVNEEKCLP CLQQKCLTSE GKASSGSGAE QPKLTQDADD MCMICFTEAL
SSAPSVQLDC GHVFHFHCSK AVLTRRWNGP RISFGFSQCP ICKMDIQHSA LAEILDPIVA
LKADVKRKAL MRLEYEGLAK NLDSKDLSTY AMERYAYYVC SQCEKAYYGG EARCDAELGE
NYNPQELVCG GCSDVVKAKM CPKHGTDFLE YKCRYCCSVA VFFCFGTTHF CDTCHDDFQR
LTNIPKNKLP KCPAGPKAKQ LIGEECPLHV IHPSTGEEFA LGCGICRNAH TF
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