ID   B0WCT2_CULQU            Unreviewed;       524 AA.
AC   B0WCT2;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=Galactose mutarotase {ECO:0000256|ARBA:ARBA00021023};
DE   AltName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00032729};
GN   Name=6036466 {ECO:0000313|EnsemblMetazoa:CPIJ004867-PA};
GN   ORFNames=CpipJ_CPIJ004867 {ECO:0000313|EMBL:EDS43808.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS43808.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS43808.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ004867-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ004867-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose = beta-D-galactose; Xref=Rhea:RHEA:28675,
CC         ChEBI:CHEBI:27667, ChEBI:CHEBI:28061; EC=5.1.3.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00001712};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28677;
CC         Evidence={ECO:0000256|ARBA:ARBA00001712};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000256|ARBA:ARBA00004947}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS231890; EDS43808.1; -; Genomic_DNA.
DR   RefSeq; XP_001846516.1; XM_001846464.1.
DR   AlphaFoldDB; B0WCT2; -.
DR   STRING; 7176.B0WCT2; -.
DR   EnsemblMetazoa; CPIJ004867-RA; CPIJ004867-PA; CPIJ004867.
DR   KEGG; cqu:CpipJ_CPIJ004867; -.
DR   VEuPathDB; VectorBase:CPIJ004867; -.
DR   eggNOG; KOG1604; Eukaryota.
DR   HOGENOM; CLU_523999_0_0_1; -.
DR   InParanoid; B0WCT2; -.
DR   OMA; TWETSNR; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR   PANTHER; PTHR10091:SF0; GALACTOSE MUTAROTASE; 1.
DR   Pfam; PF01263; Aldose_epim; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   REGION          423..460
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..460
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  59808 MW;  38FCF5D44E45D78C CRC64;
     MIDQISNLPS ESPECLHVQR FTWETSNRLT FEVITLDAAI VGLRVPDRDF EAEEVILASG
     SLKEYLHYDG QKLTSAIQSV PLKRRSAWSQ RLWSPYVNGS DLIMTNVVVE ECRNLMIRVK
     FSVAHNNVIR INYEVVSDRA LQLDTGHRMV LNLGGKMAAH FGTYDHVVQI SGDRFYRVKK
     GHLRDNVEKD VAEDLADLRV AQHVGMAIYK SEQDGFNGVY KLMGSDQDQE FNLRLIQARR
     GRVMEVYSNF RWLHFSTLDE LPNPMGLIAP FYASLGVKHV EQIFDLKGLV NSVVRFIEGD
     DEEPMESVVS VPRSDTVNES EVRVMIDDLL LKDIEEKIQA LKDAKILTPR EAREIIEDLL
     LLSLERMSKS SVDSRSIDEE SIRAFIEELV MQNLDRISDE ERIRELIEEL VLKTVSRTSL
     SGMSSSTEER LSRSTVVEEL VRRSGEGSTE SRLEEQSEEP LHEFQKHSGI LLQLSGQPLL
     KKCRRKCVFT MPNHDRQLVY KHSVLLKFGL CRAPSTGDQS NTSI
//