ID B0WEP0_CULQU Unreviewed; 183 AA.
AC B0WEP0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=MD-2-related lipid-recognition domain-containing protein {ECO:0000259|SMART:SM00737};
GN Name=6037245 {ECO:0000313|EnsemblMetazoa:CPIJ005751-PA};
GN ORFNames=CpipJ_CPIJ005751 {ECO:0000313|EMBL:EDS45756.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS45756.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS45756.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ005751-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ005751-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NPC2 family.
CC {ECO:0000256|ARBA:ARBA00006370}.
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DR EMBL; DS231910; EDS45756.1; -; Genomic_DNA.
DR RefSeq; XP_001847174.1; XM_001847122.1.
DR AlphaFoldDB; B0WEP0; -.
DR EnsemblMetazoa; CPIJ005751-RA; CPIJ005751-PA; CPIJ005751.
DR KEGG; cqu:CpipJ_CPIJ005751; -.
DR VEuPathDB; VectorBase:CPIJ005751; -.
DR VEuPathDB; VectorBase:CQUJHB006315; -.
DR eggNOG; ENOG502S5HZ; Eukaryota.
DR HOGENOM; CLU_1476571_0_0_1; -.
DR InParanoid; B0WEP0; -.
DR OrthoDB; 3661184at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:InterPro.
DR Gene3D; 2.60.40.770; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306:SF55; GEO08227P1-RELATED; 1.
DR PANTHER; PTHR11306; NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 59..174
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 183 AA; 20119 MW; 1A6C9851BC6FFFE5 CRC64;
MEKQCCKKTQ LPSYTSPNNN NETQQALPKT GNLRPSRPVT TTTNDNNATA EVAECCSGRT
TCTGYGKVLN SRKAGLLVES GAGQNATISF DYTAGFDAKV ATAKAWWTMP SLDLPFIGMD
NDACKYTGCP IVAGRKQAYS YELPIMKIFP SRAYDVKWQL LNENGEQCCF IIPIVIKNKR
GRI
//
