ID   B0WFJ9_CULQU            Unreviewed;       619 AA.
AC   B0WFJ9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=adenylyl-sulfate kinase {ECO:0000256|ARBA:ARBA00012121};
DE            EC=2.7.1.25 {ECO:0000256|ARBA:ARBA00012121};
GN   Name=6037587 {ECO:0000313|EnsemblMetazoa:CPIJ006069-PA};
GN   ORFNames=CpipJ_CPIJ006069 {ECO:0000313|EMBL:EDS26267.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS26267.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS26267.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ006069-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ006069-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- PATHWAY: Sulfur metabolism. {ECO:0000256|ARBA:ARBA00004678}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS231918; EDS26267.1; -; Genomic_DNA.
DR   RefSeq; XP_001847483.1; XM_001847431.1.
DR   AlphaFoldDB; B0WFJ9; -.
DR   STRING; 7176.B0WFJ9; -.
DR   EnsemblMetazoa; CPIJ006069-RA; CPIJ006069-PA; CPIJ006069.
DR   KEGG; cqu:CpipJ_CPIJ006069; -.
DR   VEuPathDB; VectorBase:CPIJ006069; -.
DR   VEuPathDB; VectorBase:CQUJHB011134; -.
DR   eggNOG; KOG4238; Eukaryota.
DR   HOGENOM; CLU_009463_3_0_1; -.
DR   InParanoid; B0WFJ9; -.
DR   OMA; TENCTPE; -.
DR   OrthoDB; 22780at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0000103; P:sulfate assimilation; IEA:InterPro.
DR   CDD; cd02027; APSK; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR   HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR   InterPro; IPR002891; APS_kinase.
DR   InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR024951; Sulfurylase_cat_dom.
DR   NCBIfam; TIGR00455; apsK; 1.
DR   PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR   PANTHER; PTHR11055:SF1; PAPS SYNTHETASE, ISOFORM D; 1.
DR   Pfam; PF01583; APS_kinase; 1.
DR   Pfam; PF01747; ATP-sulfurylase; 2.
DR   Pfam; PF14306; PUA_2; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000313|EMBL:EDS26267.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          261..417
FT                   /note="ATP-sulfurylase PUA-like"
FT                   /evidence="ECO:0000259|Pfam:PF14306"
FT   DOMAIN          426..468
FT                   /note="Sulphate adenylyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01747"
FT   DOMAIN          495..609
FT                   /note="Sulphate adenylyltransferase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01747"
SQ   SEQUENCE   619 AA;  69212 MW;  209BD588ADFB8058 CRC64;
     MFVKRRKFPN SNNNEILNNS NYEKPKQQVA KLRCTKHKDC NGGTSECLQV ATNVTEQKHN
     VTREVRGQNL GLCRGFRGCT LWLTGLSGAG KTSIAFELEA YLVSKGIPAY GLDGDNIRTG
     LNKNLGFSQV DREENIRRVA EVAKLFADSG VVSICSFVSP FAEDREMARK IHKDADLKFF
     EIHVNTPLEV CESRDVKGLY KKARQGSIQG FTGVTQAYEA PESPDLAVST EGVTVRQSTY
     KLIKLLEDEN IIPKFIKEDE PIPELFVPDH LRVEVEAEAK TLPSIPISTV ELQWLQVLAE
     GWAHPLKGFM REKEYLQALH FNCVLSEDET MRENQSIPIV LSVSESDKNK LDGVSALSLS
     YEGRLVAILR KPEFYAQRKE ERCARQFGTA NGDHPYIKMI MESGQYLVGG EVEVLERIVW
     NDGLDSYRLT PNELRKKFQD IKADAIFAFQ LRNPIHNGHA LLMSDCRRQL VERGFKNPGS
     VASSTGGVGP RRRRAAAGMN AGANFYIVGR DPAGMPHPDK NMYPDGNLYD GAHGARVLKM
     APGLDSIEIL PFRVAAYDKS VSQMAFFDPA RKGDFDFISG TRMRTLARTG QDPPLGFMEP
     KAWKILAEYY QSLKSGSTN
//