ID B0WHF9_CULQU Unreviewed; 2420 AA.
AC B0WHF9;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Phorbol ester/diacylglycerol-binding protein unc-13 {ECO:0000313|EMBL:EDS27709.1, ECO:0000313|EnsemblMetazoa:CPIJ006394-PA};
GN Name=6038325 {ECO:0000313|EnsemblMetazoa:CPIJ006394-PA};
GN ORFNames=CpipJ_CPIJ006394 {ECO:0000313|EMBL:EDS27709.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS27709.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS27709.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ006394-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ006394-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS231935; EDS27709.1; -; Genomic_DNA.
DR RefSeq; XP_001848143.1; XM_001848091.1.
DR STRING; 7176.B0WHF9; -.
DR EnsemblMetazoa; CPIJ006394-RA; CPIJ006394-PA; CPIJ006394.
DR KEGG; cqu:CpipJ_CPIJ006394; -.
DR VEuPathDB; VectorBase:CPIJ006394; -.
DR VEuPathDB; VectorBase:CQUJHB012597; -.
DR eggNOG; KOG1011; Eukaryota.
DR HOGENOM; CLU_229679_0_0_1; -.
DR InParanoid; B0WHF9; -.
DR OMA; YAKHHEF; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd04027; C2B_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1262..1312
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1373..1497
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1805..1948
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 2059..2225
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 2245..2372
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 800..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 960..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..819
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..906
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2420 AA; 267942 MW; 279D18EE617CB03F CRC64;
MKEQHQEVDR SFSVDIKREE IINSQIRRYS SYSPYCSPYA TRSLERTTAC TVQDLYASHG
LKDLHHLHQD FIINDYTDKI ATNIDLLDTE LKFAWAALNL LNEEYTRMSE KVFKLQSLNV
SQQRIVQNLQ FMEENRKAYL DMIPDYAKHH EFSLQEQSRL REDLQYRDCI NEAYMNHMQP
GPAYGYGQVP SAEEMAAAYN QEYWGMRRNL SNIPEVLHGE AENGGGGAYG YGQDVPMPAP
QAHRLSTNPF LQVVEGAGGI LREIEPADNA ALIEEQLRAS FLNHAKQMEM ELQASPAMMK
HQQELRQQQQ QQQLLQQKQF KHDDVRALIT RVMDDEDVAS LSSEEMEKVR VFMSKNSGEL
REIFAEEFSP LAKVGKGGEK ILAQNKLGGV SPKKEFNKFI HLPDAAGIAS LTNDDLLTVE
NGTISIQDKS STTIADNEFK LNLNSGGVVH PANGTNGTSP KKLSEFSPFG MQKAMERKES
GNVPSFADLM NSKPCGTDAA GLTFTNLNGE PESIFSQSFK EAVEAKLAGQ AVQMAGNMMS
MGEPVPMFPT VAMKPNISEA LEGGGVRRPS VTEALEIRRP SVTESLFPTV ARKPSITTTS
VASELQRRLS VEDPQHPSAF APVRKLSIVE PVADPAPTAP SIFQPLARKP SVTETAAPST
SPPMFTPLPG CTTITDTPEM QAIYESLSRK SSLPTLGDGT FFPSLDITDS GFAECTDGMS
LFPTTLTLST TLSSTTDAPV SLPDFSTLST MAAETSEASN SSFLHMSMNS SGISEASDSI
TLLPPVSAIL VTTDQSTIAV PKPAEPAPPP LPQPLPPISA APATMAALAD SKPIAQATAP
PPTVTSPPAP LATAEVVKPK PTAAAAVTKP TPAAVPPTAV TKPTPVAQAP TKPQPAPVPK
PAPQQPTPEA KQAGGFFGTT TSTFGGFFNK VNKSLSHQDS TDSLLGTKTK ALFSSVKSSF
SLESPKQSLD EANSQPSSSQ SATSGAASLE SSSPPGSVQV PSTPEEPHST TPPPSPDVAL
AQSHQQQQQQ QLQPHQQSSP PQELQQYPQT SPPGGGEQQQ SSPYDQPQLA SEFPELCNGN
GSSGTPLSNS AQPFPGAAAE ETVLDGEAPA PPTHRKQSLF RAQGSEDGEG GSKWKLLKTL
KEKRIEEKQK VVDEGEADDA GIFKKVDCKA EEEEKRNGTA DSGRGNGLGD NTFYSNIDSM
PDIRPRRKSI PLVSELTMAA TKRQAGLTSA VPRATLNDEE LKMHVYKKAL QALIYPISST
TPHNFVLWTA TSPTYCYECE GLLWGIARQG VRCTECAVKC HEKCKDLLNA DCLQMCFAGA
SEKSSKHGAA EDKANSVIAA MKERMKQRER DRPEIFEVIR KVFNVEEKSH AGHMKAIKQS
VLDGTSKWSA KIAITVICAQ GLIAKDKSGT SDPYVTVQVS KVKKRTRTMP QELNPVWNEK
FNFECHNSSD RIKVRVWDED NDLKSKLRQK LTRESDDFLG QTIIEVRTLS GEMDVWYNLE
KRTDKSAVSG AIRLHISVEI KGEEKVAPYH VQYTCLHENV FHYLCEENCG AVNLPQTKGD
DGWKIYFEEN PEEIVDEFAM RYGIENIYQA MTHFHCLSTK YLCAGVPAVM STLLANINAY
YAHTTASSAV SASDRFAASN FGKEKFVKLL DQLHNSLRID LSMYRNNFPA SSQEKLMDLK
STVDLLTSIT FFRMKVQELS SPPRASTVVK DCVKACLRST YQFLFENCYE LYNREFQVDP
NEAKREGEDH GPKLENVDFW HKLIALIVSV IEEDKNSYSA VLNQFPQELN IGQVSAATMW
SLFAIDMKYA LEEHEQHRLC KSSAYMNLHF KVKWLYTNYV KEVPPYKGAV PEYPAWFEPF
VMQWLNENDD VSLEYLHGAF KRDKKDGFQK SSEHALFSNS VVDVFTQLTQ CFDVVSKLDC
PDPEIWKRYM RRFAKTIVKV LLAYVDIVKT EFPDITHEER TACILMNNIQ QLRVQLEKMF
DSMGGDKLEE DAANILKELQ QNLNTALDDL ATQFAISLDP RITGSVRELG DLLQQVKSQT
SLFHSAPADD ANMIAMEADE VLRPLMDLLD GSLSMYAQSC EKTVLKRLLK ELWKIVIRTL
EKTIVLPPMT DRTMVFKHLT DNAKNLAANA KIEDMSRLIK NHMAGKQDAK SMLGGVMDIS
KEIEKNLSPK QCAVLEVALD TIQQYFHAGG NGLKKPFLEK SSELQSLKYA LSLYTQTTDT
LIKSFVSGQG ASEEGGINHD DASVGEVSIQ IDVSSNPENG EQKISVKVIA ANDLKWTVPS
GMFRPFIEVN LIGPHLNDRK RKFATKSKSN NWSPKYNETF HFIIGNEEQL EFFELHTCVK
DYCFAREDRL VGVAILKLKD VVDQVTGTDY GLRLSECCVR ESVDTEEYHV LVWGFLSYLG
GEISDPVKRL EDRESSTRFV
//
