ID B0WHS3_CULQU Unreviewed; 279 AA.
AC B0WHS3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Wiskott-aldrich syndrome protein {ECO:0000313|EMBL:EDS27940.1, ECO:0000313|EnsemblMetazoa:CPIJ006699-PA};
GN Name=6038460 {ECO:0000313|EnsemblMetazoa:CPIJ006699-PA};
GN ORFNames=CpipJ_CPIJ006699 {ECO:0000313|EMBL:EDS27940.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS27940.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS27940.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ006699-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ006699-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; DS231939; EDS27940.1; -; Genomic_DNA.
DR RefSeq; XP_001848257.1; XM_001848205.1.
DR AlphaFoldDB; B0WHS3; -.
DR STRING; 7176.B0WHS3; -.
DR EnsemblMetazoa; CPIJ006699-RA; CPIJ006699-PA; CPIJ006699.
DR KEGG; cqu:CpipJ_CPIJ006699; -.
DR VEuPathDB; VectorBase:CPIJ006699; -.
DR VEuPathDB; VectorBase:CQUJHB012028; -.
DR eggNOG; KOG3671; Eukaryota.
DR HOGENOM; CLU_015385_3_0_1; -.
DR InParanoid; B0WHS3; -.
DR OMA; RCQTQCT; -.
DR OrthoDB; 3837860at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011026; WAS_C.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 34..143
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 225..238
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT REGION 135..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 31659 MW; 408A05839BA6CDD7 CRC64;
MKQPATTDAD RASKANRPSM LLTNEENEQL FGLLGRRCQT QCTAVVQLYL TQSPAHASWV
KKWTGALCFV KDNIRKSYYF RLYCLKTNRQ VWEQELYEKL DVTKPRPFLI VFEGAEGIVA
FNFAMEDEAT AFMNTTTSTL HNRNRRRDDR IKRNSTRKDP PPARPPPVSN QNNAFDNTVT
LRHKPSFGAP TAAAFPQQPA AAAAMTPHQR PTKNKAKGRL RKEDIGMPSN FKHVTHVGWS
PTSGFDLSGE EDTLKPFLEK AGVRDQHVSR KCHFVTLLK
//
