ID B0WIM3_CULQU Unreviewed; 4612 AA.
AC B0WIM3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Ciliary dynein heavy chain 5 {ECO:0000313|EMBL:EDS28578.1, ECO:0000313|EnsemblMetazoa:CPIJ007215-PA};
GN Name=6038854 {ECO:0000313|EnsemblMetazoa:CPIJ007215-PA};
GN ORFNames=CpipJ_CPIJ007215 {ECO:0000313|EMBL:EDS28578.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS28578.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS28578.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ007215-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007215-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; DS231950; EDS28578.1; -; Genomic_DNA.
DR RefSeq; XP_001848557.1; XM_001848505.1.
DR STRING; 7176.B0WIM3; -.
DR EnsemblMetazoa; CPIJ007215-RA; CPIJ007215-PA; CPIJ007215.
DR KEGG; cqu:CpipJ_CPIJ007215; -.
DR VEuPathDB; VectorBase:CPIJ007215; -.
DR VEuPathDB; VectorBase:CQUJHB005150; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_9_1_1; -.
DR InParanoid; B0WIM3; -.
DR OMA; IAYEYMK; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 2.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 255..810
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1417..1821
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1956..2283
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2439..2583
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2807..2883
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2964..3226
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3239..3585
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3613..3833
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4079..4188
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4219..4358
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4365..4485
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT DOMAIN 4485..4609
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3248..3321
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3468..3516
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 94..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4612 AA; 530986 MW; 458612E868FF51FE CRC64;
MTESPDSQRR REECERKARR GEMDPRLEFT FQLLMDATGL PRHQIMDHIF EGNMLDEINQ
LFLPNMRNKL MWFYQEVDEV DMPAERDINK PGPSRAGASS SSKTPQGASG GAHNRPHKLF
ITDGWSCAFT GICIYMFRIN IQKQLPEEGF HKDLYCGYID ANRVGLVTSI ERIVEFVFMQ
ALAYPNIESE DEDMSCNLIK SQLLPGLRSF CSALRVCEQV CNHFNVFDDG KNIVCRVDTL
AEVREMSKSA SICAELEERV NNWIKGIAKI LMESEQLRRE NDSSGPQDEL EYWKRRGAQF
SQLLSHLQER EVQWTLYCLS QSGSKVLKQW KETDKKITFC YNEARDNSKF IQAMEACCHS
LYLDDPVNMK ESIVSLLQTV RLIYSVSQFY NTSERTSTLM VKITNQMIET CKSYITCRGK
ETIWTQDRDL VRTKLTNCLK LNHIYRETYH AVKSQPFLPD QIPFAFSENY VFGKFDTFCD
RLSKIISMFS LIDDYNHLFE RRLEGLLLGE ALEDAMNTFD EARVEIIMKK YDYLDQRNLD
FNNDFQVFMQ KTDTLKETIA SMIEHNFDSV WETPQGIRFL VRFEKVSEKI PLSTMDEKYQ
RVSKYCEKEI DRILKLFRKQ RDDPPLPRNF PPIAGRIKWC RSLEYHLVEL VTTVTTHPVL
AALPSTKDIE NRFGSAKIIL TEYEQEMTQI WLSQDVSVAD ACLVQPILAL QGDRLVVNLH
PTIPLLIRES KCMAKMKIDL PIVAATLLCK QNHFNTIQDS LNSLIKMFLN TIKKVKLEVR
PLLLPQLVRL TAMMKPGLKS INWTSPRWIE FFDNCKEAIE TFDVLVARVH DIYSNRILHV
LTSMQDIQLQ SLPNDDEMWT VEEFLDYTEE TCRQAATELN RKSQMVEEAV EEVLDLVHRA
SQIFKRMVGA ENDFFVDEDK KPSEKSTPTP EADNDDGNGQ QQDWSILWSC FENPLQLLSH
HGGGLPKGMQ DMVFNAVSEM RRYYSRKVID VLIRVTRTSL DCLRRRFIEV EGEDLPRKPI
FILQSLLMIP NVTIRPNLEE LQEALSIAGK QITGVSKGVA QWNTGKDIDD KPRPSAAALA
SAATAAKLAK ANAAALDEKS RRRKMYRLKS EEKQKMVHMT KSFYSYVMDN KEVVKTLSLL
SSCIRNMKPE LQMFVEKWKP YHFLWKNDKT IRQLLENTLL EFESTLRRLV ELDVNLTVEP
DMQYFGQSIA LSTEKLKFGL TIEIKSCTHK LGQAMKKKYK REMDYVYAVI NEMDRKLDRQ
IRDLDDVRTV MDTLSKIREQ EVDMELKIEP IEDAFNMMHK YEIQVDREQM DQVDNLRYTW
VRLQSRAKEV HCKLLEMQPD FQSDLRANLE KFKQDKLDYV SEYRVAGPME PGLTPREASD
KLLLFQNRFD GMWRKLQTYQ SGEELFGLPQ SDYPELGQIK KELNLLQKLY KLYNDVIDRV
SSYYDIPWSD VDIEEINNEL MEFQNRCRKL PKGLKEWPAF YALKRTIDDF NDMCPLLELM
ANRAMKPRHW QRIMEVTKYT FEFDSEGFTL KHILEAPLLK HKEDIEDICI SAMKEKDIEA
KLKQVTNEWS AHELSFMTFN NRGELLLRGD TTAETIGQLE DSLMVLSSLL SNRYNAPFRK
QIQQWVYDLS NSNDILERWL LVQNMWVYLE AVFVGGDIAK QLPKEAKRFS KIDKSWQKIM
QRAHETPGVV ACCVGDDLLK QLLPHLQEQL ELCQKSLSGY LEKKRMMFPR FFFVSDPALL
EILGQASDSH TIQNHLLSIF DNTRFVKFHD IEYNKMMAIT SSEGEQIPLD RAIRAEGSVE
TWLTSLLQSM QQSLHSIIRQ AYALMNDPNF TLLSFLEKLP AQVGLLGIQM IWTRDAEMAL
MQARHEKKVM SETNNKFLEL LNTLIDQTTR DLLKIERTKF ETLITIHVHQ RDIFDILCRM
NIRSSNDFEW LKQCRFYFKE DVDKTWINIT DVTFVYQNEY LGCTDRLVIT PLTDRCYITL
AQALALSMGG SPCGPAGTGK TETVKDMGKT LAKYVVVFNC SDQMDYRGLG RIYKGLAQSG
SWGCFDEFNR IELPVLSVAA QQVAVILTAR KEKKKRFIFT DGDDIEMNME FGVFITMNPG
YAGRKELPEN LKIQFRTVAM MVPDRQIIIR VKLASCGFLE NITLARKFYT LYKLCEEQLT
KQVHYDFGLR NILSVLRTLG AAKRVNHKDS ESTIVMRVLR DMNLSKLIDE DEPLFMSLVS
DLFPNQTLEK TSYGDLETAI AYQVEQAGLI YHAPWVLKLI QLYETQQVRH GIMALGPPGA
GKTCCIRILM KALTDIGLTH KEMRMNPKAI TAAQMFGRLD VATNDWTDGI FSALWRKTLK
AKKGEYTWLV LDGPVDSIWI ENLNSVLDDN KTLTLANGDR LSMAPTCKII FEPHNIDNAS
PATVSRNGMV YMSSSGLDWK PILQAWLKTR SPQEKRVFNE LFDSTFLKIY TWTTQNLMLM
MEVLQCNFIQ QMIYLLDGLV PVLSDNEQEA VASTTGSLDD DVNDDEAPKV MDEACTPEHL
YRLYVFALAW GIGAYLNSAD RLKLDAHTKK NYRNLDFPSS DEKPDSTIFD FFVSPMGSWQ
LWKTLVVPYV YPEFSTPDYL SILIPIVDNV RIDYLINVIV KQEKAVLLIG EQGTAKTVIM
KSFMKKLNTD THMGRSFNFS SATSPYHFQK TIESYVEKRM GNMFGPGGGR KLLVFIDDIN
MPQINEWGDQ ITNEIVRQTM DMRGFYSLEK PGEFTNIIDV QFAGAMGLPG GGRSDIPARL
KRQFSVFNCN IPDNTSIDTI FKTLGEGHYN VKRGFSLEVR KLVKKLVPLT RVLWQHTREH
LLPTPAKFHY VFSLRDLSRI WQGMIGTLST VITSESVLIM LWKNECSRVF ADRFVSLSDT
EWFLEEMFKV LETDLGPEYR EMAVPSPVFV DFMRDAPEPT GEEGEETDME LPKVYEPVSD
FSILRDRLKM FLLQFNEMIR GTGMDLVFFP DAMLHLVKIS RIIRHPRGNV MLVGVGGSGK
QSLTKLASFI AGYKTFQISL TRSYNVANFL EDLKLLYRSC GVQGKGTTFL FTDLDVKEES
FLEYLNNILS SGVISNLFNR DEQTEIVSEL TPTMKRENQK KNVTQETVME YFLQRVCHHL
HVVFCFSPVG ETFRRRIMRF PALVSGCTVD WFQPWPKDAL VAVARHFLTD FSIECSPEVK
DELVHALGTI QDIVSMTSTE YYQRFRRATH VTPKSYLNFI AGYKNIYTQK HKELCDGAEK
MDTGLEKLAE ASESVEILKI ELAVMEKDLV EASAKAERVL VEVTERAMQA EIFKNQVQVV
KEKAEALVQN IAQEKGFAEE KLEAAKPALE EAEAALNTIK PAHIATVRKL GRPPHLIMRI
MDSVLIMFQR KLHPVIADTS APSPKPSWQE SLKMMASTTF LLQLQNYPKD TINDEMIEHL
QPYFRMEDYN MDTARRVCGD VAGLLSWTKA MAFFHGVNKE VLPLKSNLML QEARLKIAMD
DLAAAEDQLA ERENALQKVK DQYDAAVSEK QRLTDAANSC LRKMTAATAL INGLGGEKAR
WTQQSKEFKI QLGKLVGDVL LATGFLSYCG PYNQEFRGTL FKTWMDILKN RTIPYTTGLS
IIGMLTDSAT ISEWNLQGLP NDELSIQNAL IVTKSSSYPL LIDPQSQGKI WIKCKEDQNE
LQITSLNHKY FRTHLEDSLS LGRPLLIEDV GTELDPVIDN VLEKNFIKSG SMEKVLVGDK
ECDVMPGFML YITTKLPNPP FSPEISSKTS IIDFTVTMRG LEDQLLGRVI LMEKADLEAE
RVQLFESVMK NQRSMKELEA NLLLRLTSTE GSLVDDEALI EVLQETKTTA EDVNQKLKIA
EVTEKKIMVA REEFRAVAAR GSILYFLIVE MSNVNVMYQN SLKQFLIIFD NSITKSTKSN
VTEERIGIIL RYLTYEVWAF TSRSLYERHK QLFTLMLAIK IDYQKGTISH DEFMAFVKGG
ASLDLNAVVA KPFRWILDIT WLNLVEISKL KTFHGILKKI EYNERDWKQW YETERPELEV
IPCDYENELD VFRKLLLIRS WSPDRTISQA RRYIEVSLGK EYGEMHILDL ELTWTESEPR
TPLVCILSIG SDPTVQISAL AKTKGIVLKT VSMGQGQEYH ARKLMTDCMA GGGWLLLQNV
HLSLTFCNEI IDILIETEHV AETFRLWVTT ETHEHFPIGL LQMAIKFTNE PPQGIRASLK
RSYQTYTQDY LDYTSAPQWP PLLYTVAFLH CVVQERRKFG PLGWNIPYEF NAADFSASVQ
FIQNHLDEMD PKKGVSWQTL CYMLGEVMYG GRVTDDFDKR LLTTFTQVWF SEHLLTPSFE
FYKGYRVPNS RNIQTYVDYI NQLPPTDTPE VFGLHPNADI TYQINTAKGI LDTILSVQPK
EGGGGGGETR ESIVCQLAND MLRKLPPQYV AFEVKESLNR MGALLPMNIF LRQEIDRMQR
VINTVYTNLC DLKLAIDGTI IMSNYLRHAL DAMYDARIPE KWQKEVTRAH KGWALDSVVL
QNQITRYNKE DIHDAPQEGV YVSGLFLEGA SLDRRSGKLI ESKAKILYEQ MPVIYIYAIN
TTAGKDPRLY ECPIYRKPQR TDQKYVGSID FETDFNPRHW TLRGVALLCD IK
//
