ID   B0WIR1_CULQU            Unreviewed;       614 AA.
AC   B0WIR1;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Adenylate kinase isoenzyme 5 {ECO:0008006|Google:ProtNLM};
GN   Name=6038896 {ECO:0000313|EnsemblMetazoa:CPIJ007066-PA};
GN   ORFNames=CpipJ_CPIJ007066 {ECO:0000313|EMBL:EDS28638.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS28638.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS28638.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ007066-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007066-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the adenylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00007220}.
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DR   EMBL; DS231951; EDS28638.1; -; Genomic_DNA.
DR   RefSeq; XP_001848595.1; XM_001848543.1.
DR   AlphaFoldDB; B0WIR1; -.
DR   STRING; 7176.B0WIR1; -.
DR   EnsemblMetazoa; CPIJ007066-RA; CPIJ007066-PA; CPIJ007066.
DR   KEGG; cqu:CpipJ_CPIJ007066; -.
DR   VEuPathDB; VectorBase:CPIJ007066; -.
DR   VEuPathDB; VectorBase:CQUJHB005089; -.
DR   eggNOG; KOG3079; Eukaryota.
DR   HOGENOM; CLU_012824_0_0_1; -.
DR   InParanoid; B0WIR1; -.
DR   OMA; VTHCDTL; -.
DR   OrthoDB; 3716429at2759; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0019205; F:nucleobase-containing compound kinase activity; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR000850; Adenylat/UMP-CMP_kin.
DR   InterPro; IPR033690; Adenylat_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23359:SF111; ADENYLATE KINASE ISOENZYME 5-LIKE PROTEIN; 1.
DR   PANTHER; PTHR23359; NUCLEOTIDE KINASE; 1.
DR   Pfam; PF00406; ADK; 2.
DR   PRINTS; PR00094; ADENYLTKNASE.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00113; ADENYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          291..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   614 AA;  66812 MW;  EDE64F96E3C7C5B6 CRC64;
     MGICLDTDKG NTTQEGDESD WKGGGGRGDD PSQRRSAIVR SPTLGGGSPT ANGGGMQNNG
     KVKFDPPKVP VIFVLGGPGS GKVTHCDTLM QERRGVTHIN MMDLLQQYAI GNDMQDFSKL
     PSRTVTEVLM LEMKMSPAAK TYLVSGYPRS MRDVVEYSEK IQVINGVILI SWRQTILQRQ
     IDYGAKLGHV VLSLAKMELD NFFKNVMPVA DYFDQSDMLI AINGERAPSE VYKDFRSAVL
     DILGAQENQE ALLNGVAGMG RGVDDIPGSI VSVDTAPSQA KVITAVPSHQ VEINSRTRTP
     TPPPPVQRQQ SRVELRPGSV VELGKPGRIP PVLWVIGGPG SNKATLCLKA VGINPGVGRL
     LRAIAESDPR VGTDNYAVKE AITAGEMVPK KSLDRLIENQ LAQLSDKKGV IIDGYPRDLM
     QVNDFEQKYH QSPTIILLDC SKLQLGRGRL DDTVSSFRRR LELFRELTLP MLKEMDTAGR
     LTIVDGDTDS PTVQREFERI VRDNIQKVLK QQESAGNRAT EAITPVRIGN FKSAIQRSRK
     SAAKSSSQQD AIVHDLDADV PGVVPTISHH VSLANGHLGG GGAVPVAARN GHVPNGKLNF
     RNMLDEADHY DSHM
//