ID B0WIY6_CULQU Unreviewed; 627 AA.
AC B0WIY6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00041297};
GN Name=6038985 {ECO:0000313|EnsemblMetazoa:CPIJ007302-PA};
GN ORFNames=CpipJ_CPIJ007302 {ECO:0000313|EMBL:EDS28847.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS28847.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS28847.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ007302-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007302-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + tetracosanoate = AMP + diphosphate +
CC tetracosanoyl-CoA; Xref=Rhea:RHEA:33639, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:31014, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:65052, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036436};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33640;
CC Evidence={ECO:0000256|ARBA:ARBA00036436};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very long-chain fatty acid + ATP + CoA = a very long-chain
CC fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:54536,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58950, ChEBI:CHEBI:138261, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00036527};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54537;
CC Evidence={ECO:0000256|ARBA:ARBA00036527};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231954; EDS28847.1; -; Genomic_DNA.
DR RefSeq; XP_001848670.1; XM_001848618.1.
DR AlphaFoldDB; B0WIY6; -.
DR STRING; 7176.B0WIY6; -.
DR EnsemblMetazoa; CPIJ007302-RA; CPIJ007302-PA; CPIJ007302.
DR KEGG; cqu:CpipJ_CPIJ007302; -.
DR VEuPathDB; VectorBase:CPIJ007302; -.
DR VEuPathDB; VectorBase:CQUJHB013295; -.
DR eggNOG; KOG1179; Eukaryota.
DR HOGENOM; CLU_000022_46_2_1; -.
DR InParanoid; B0WIY6; -.
DR OMA; AHCTALI; -.
DR OrthoDB; 1650656at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43107:SF21; FATTY ACID TRANSPORT PROTEIN 1, ISOFORM F-RELATED; 1.
DR PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 65..414
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 505..580
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 627 AA; 69738 MW; 2FDCCBA451BE83BE CRC64;
MALEREQVSL RLYTAIATAY YWTYDDPAAA TADQTLKRTA LSRYVKLLFL VKKYARQNAT
IADIFAEYVA KQPEKVCFVF EGREWTFREV SDYSNRVANV FHTHGYKHGD VVGLVMENRP
EFVGTWLGLS KLGVIIPLIN HNLRKNALLH SITVAKCNAL VYSEALCEAI GEITESLPST
MALYQFNDAI QQTVLANSKD LATLLQSASK ELPTTNVKKA SHHDQLLYIY TSGTTGLPKA
AVITHSRYLF ITAAIHIVAG FSPNDVFYTP LPLYHTAGGM MSIGQALIFG ATVAIRKKFS
ASQYFTDCQK YNCTVGQYIG EMCRYILATP ESGNDKDHKV RLIFGNGLRP QIWPQFVERF
NIPRVAEFYG ATEGNANIVN IDNTVGAIGF VSRIIPSVYP ISIIRADPAT GEPIRGKDGL
CQLCQPNEPG VFIGKILPNN PSRAFLGYVD KGASEKKIVR DIFKKGDSGF LSGDLLVADE
RGNLYFKDRT GDTFRWKGEN VSTSEVEAEV SNASGYRDTV VYGVEIPNLE GRAGMAAILD
PEGQVDLVKL ADTLKQSLPS YARPMFVRLL TKVDMTGTFK LKKLDLQKEG FDPNVIEDAV
FYLSPKGAYE RLTKEAYEQI KRGEIRF
//
