ID B0WJ55_CULQU Unreviewed; 442 AA.
AC B0WJ55;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=serine--tRNA ligase {ECO:0000256|ARBA:ARBA00012840};
DE EC=6.1.1.11 {ECO:0000256|ARBA:ARBA00012840};
DE AltName: Full=Seryl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031113};
GN Name=6039062 {ECO:0000313|EnsemblMetazoa:CPIJ007184-PA};
GN ORFNames=CpipJ_CPIJ007184 {ECO:0000313|EMBL:EDS28934.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS28934.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS28934.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ007184-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ007184-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type-1 seryl-tRNA synthetase subfamily.
CC {ECO:0000256|ARBA:ARBA00010728}.
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DR EMBL; DS231955; EDS28934.1; -; Genomic_DNA.
DR RefSeq; XP_001848739.1; XM_001848687.1.
DR AlphaFoldDB; B0WJ55; -.
DR STRING; 7176.B0WJ55; -.
DR EnsemblMetazoa; CPIJ007184-RA; CPIJ007184-PA; CPIJ007184.
DR GeneID; 6039062; -.
DR KEGG; cqu:CpipJ_CPIJ007184; -.
DR VEuPathDB; VectorBase:CPIJ007184; -.
DR VEuPathDB; VectorBase:CQUJHB014296; -.
DR eggNOG; KOG2509; Eukaryota.
DR HOGENOM; CLU_023797_4_0_1; -.
DR InParanoid; B0WJ55; -.
DR OMA; KVEMFVC; -.
DR OrthoDB; 239638at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004828; F:serine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro.
DR InterPro; IPR002314; aa-tRNA-synt_IIb.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR002317; Ser-tRNA-ligase_type_1.
DR NCBIfam; TIGR00414; serS; 1.
DR PANTHER; PTHR11778:SF7; SERINE--TRNA LIGASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR11778; SERYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00587; tRNA-synt_2b; 1.
DR PIRSF; PIRSF001529; Ser-tRNA-synth_IIa; 1.
DR PRINTS; PR00981; TRNASYNTHSER.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:EDS28934.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 169..408
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 442 AA; 50487 MW; 547F2442CC76FD78 CRC64;
MLAFKTLSVL KSFHLEQKLL TYARFVHHKF HLVKPSYNTD YLLNPANIPE IQHNIEHRKG
VGNIQLVHEL NNRLRSLPAN ASEAEKSQLN DQLQAELRKI PNRTHPGVLQ HGADPKVVRY
YNEKPSLGEG AKVFEFSEMT KKMNIFRMEK LGNFTGHKSY YLTGELAELE QALIRYALSK
LLARNFHLIT VPDILPARII ESCGMSTHGE RNQVYKLNYP HETLCLSGTS EMALAGYFAG
TVTEESRLPL KLTAVSRCFR AETSALHEEK GIYRVHQFTK VEMFSVCRPD QSEAMLEEFR
DIEVDLFDAL GVHFQLLDMP ACELGAPAYR KYDIEAWMPG RGMYGEISSC SDCTDYQARR
LGIQYRSGSD NSQLNYAHTV NGTACAIPRM LIALLENFQN KDYTITIPEP LRPFMRGKDK
ISRKKVLPEL KLTKRLAQEE IC
//
